Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$110K - $130K *
Lead strategic initiatives by managing complex projects from inception to launch. Collaborate across teams to implement new markets and contracts, ensuring compliance and operational readiness in a dy...
1 week ago
$69K - $101K *
Lead the charge in holistic clinical care management, enhancing health outcomes through comprehensive assessments, care planning, and coordination for diverse member populations with complex needs...
2 weeks ago
Vice Provost, Academic Affairs
$180K - $195K *
Advance academic excellence by leading institution-wide initiatives, enhancing student pathways, and driving enrollment growth. Collaborate with Deans and faculty to align academic strategies with mar...
1 week ago
Senior Regulatory Affairs Specialist
$110K - $130K *
Shape the future of health technology by driving regulatory strategies for innovative lab testing, imaging, and AI products. Collaborate with cross-functional teams to ensure compliance and accelerate...
1 week ago
$110K - $130K *
Elevate client success by managing complex projects, ensuring timely delivery, and maintaining budget integrity. Collaborate with diverse teams to drive engagement and optimize project outcomes from i...
3 weeks ago
Corporate Project Manager, Quality and Professional Governance
$88K - $105K *
Join a dynamic team to ensure compliance with healthcare quality standards, manage credentialing databases, and support operational objectives. Collaborate across departments to enhance quality govern...
5 days ago
Senior Account Executive - Merrell
$108K - $141K *
Empower growth as you manage strategic accounts, leveraging insights to drive sales, build relationships, and collaborate across teams to maximize profitability and market presence in the lifestyle se...
Reposted 4 weeks ago
$115K - $130K *
Lead the Archibus platform for a major Life Sciences client, driving enhancements and integrations while ensuring data integrity and user satisfaction. Collaborate with cross-functional teams to optim...
1 week ago
$110K - $120K *
Empower your career by leading business analysis and configuration efforts. Collaborate with stakeholders to translate objectives into actionable requirements, ensuring successful project delivery and...
6 days ago
Associate, Corporate Development
$115K - $140K *
Drive impactful growth by mapping industrial markets, evaluating acquisition targets, and building investment models. Collaborate on live transactions to shape strategic decisions that enhance manufac...
3 weeks ago
AVP - Practice Management/Training Enablement - Retirement - Remote
$250K - $325K *
Champion the development and execution of innovative sales enablement programs, collaborating with cross-functional teams to enhance training, elevate performance, and drive growth in the competitive...
2 weeks ago
$110K - $166K *
Lead the charge in managing site contract negotiations and agreements, ensuring alignment with clinical study timelines. Collaborate with cross-functional teams to enhance contract processes and mento...
Reposted 4 days ago
$100K - $120K *
Join our team to drive growth by reactivating lapsed accounts and expanding our advertising measurement solutions across various sectors. This sales-focused role combines prospecting and program manag...
Reposted today
Case Review Manager - Independent Reviews (IRO/UR)
$85K - $95K *
Oversee the quality assurance of case reviews, ensuring accuracy and completeness in documentation while collaborating with clinicians to uphold high standards in healthcare determinations and workflo...
6 days ago
$110K - $145K *
Optimize compensation strategies by providing expert advisory support, leading complex analyses, and enhancing program effectiveness. Collaborate with leaders to ensure alignment with business needs a...
2 weeks ago
Senior Director, Market & Competitive Intelligence
$170K - $200K *
Drive market and competitive intelligence initiatives to enhance strategic decision-making across teams. Build a high-performing function that delivers insights on customer behavior, market trends, an...
1 week ago
Department Manager: Physical Design Engineer
$174K - $296K *
Champion the growth of a substation engineering practice by leading a diverse team, driving operational excellence, and delivering innovative solutions for utility clients nationwide while ensuring te...
Reposted 4 weeks ago
Workers Compensation Claims Examiner | Jurisdictions: MA, CT, NH, RI, VT | Licensing: VT, CT, NH, RI
$80K - $90K *
Manage and analyze Lost-Time Workers Compensation claims, ensuring timely resolution and adherence to service expectations. Collaborate with clients and stakeholders to deliver innovative solutions in...
5 days ago
$98K - $130K *
Drive financial excellence by leading cost accounting operations, ensuring accurate reporting and analysis. Collaborate across departments to support strategic business decisions and contribute to tim...
5 days ago
Senior Manager, Trust Services & Operations
$83K - $141K *
Oversee trust and wealth operations, ensuring compliance and efficiency in fiduciary services. Lead a team to enhance service delivery, manage performance metrics, and implement operational improvemen...
2 days ago
$118K - $226K *
Transform high-net-worth client engagements by leading comprehensive financial and estate planning initiatives. Collaborate with a dedicated team to deliver tailored solutions, utilizing advanced plan...
6 days ago
$118K - $226K *
Unlock potential by leading advanced financial and estate planning for high-net-worth clients. Collaborate with a dedicated team to deliver tailored solutions, utilizing innovative tools and technolog...
6 days ago
Director, Association Partnerships & School Growth - Home Campus
$110K - $130K *
Unlock potential by building strategic relationships with athletic associations, leading RFPs, and driving school subscriptions. Own the growth strategy in new states with autonomy to shape processes...
5 days ago
Senior Manager of Global Payroll
$130K - $170K *
Champion global payroll operations by managing processes, team leadership, and compliance initiatives across multiple regions, driving strategic improvements to enhance efficiency and accuracy while e...
Reposted yesterday
$200K - $240K *
Pioneer high-growth revenue strategies across the Americas. Lead a dynamic sales team, drive go-to-market initiatives, and engage with key stakeholders to achieve ambitious targets in the cybersecurit...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.