Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$100K - $125K *
Lead and manage diverse acoustics projects, mentoring team members while collaborating with top engineers and architects on high-impact designs across various sectors, including healthcare, education...
3 weeks ago
$80K - $95K *
Manage client engagements end-to-end while mentoring associates and driving team success. Leverage technical expertise to resolve complex tax issues and enhance client service through collaboration an...
1 week ago
Senior Consultant – Federal Grants Monitoring and Program Integrity
$98K - $163K *
Analyze and support federal clients in oversight and monitoring of grant programs, ensuring program integrity and accountability. Collaborate with stakeholders to assess risks, develop recommendations...
6 days ago
Director of Financial Reporting
$125K - $150K *
Drive compliance and accuracy in financial reporting, overseeing SEC filings and governance. Collaborate with leadership to enhance transparency and support strategic initiatives while ensuring adhere...
6 days ago
Senior Director, Client Strategy
$175K - $225K *
Champion client success by leading a dynamic team to drive growth strategies, enhance client relationships, and integrate innovative solutions. Influence operational excellence while fostering a cultu...
Reposted today
Finance Consultant, Deltek Vision/Vantagepoint
$100K - $130K *
Unlock potential by partnering with clients to deliver tailored finance solutions, optimizing system performance, and enhancing project management activities. Leverage your expertise to drive client s...
Yesterday
$70K - $105K *
Engage in strategic healthcare analytics to enhance operations, improve reimbursement processes, and drive data-driven insights. Collaborate cross-functionally to optimize quality and financial perfor...
Reposted 2 weeks ago
$86K - $144K *
Unlock potential by leading the design and development of scalable generative AI services, ensuring architectural integrity and mentoring teams. Collaborate with cross-functional stakeholders to drive...
Reposted 2 weeks ago
$110K - $130K *
Elevate enterprise AI initiatives by partnering with clients to drive strategic solutions. Leverage your expertise to engage senior leaders, design impactful demos, and accelerate deal cycles, ensurin...
3 days ago
$229K - $310K *
Drive project management and business development to enhance operational efficiency in life sciences R&D, while leading diverse teams and ensuring profitability through strategic customer engagement a...
Reposted 1 week ago
Product Manager, Property Intelligence
$95K - $158K *
Transform the Property Intelligence platform by connecting customer needs with product insights. Collaborate across teams to enhance product adoption and engagement through analytics and feedback, dri...
5 days ago
Director of Enterprise Risk Management
$125K - $150K *
Champion enterprise risk management by leading strategic initiatives, mentoring teams, and enhancing risk frameworks. Collaborate with stakeholders to drive informed decision-making and ensure alignme...
2 weeks ago
Claims Team Leader Auto Litigation
$86K - $129K *
Inspire a high-performing claims team by managing investigations, settlements, and compliance. Drive operational excellence while fostering staff development and effective communication to achieve bus...
Yesterday
Senior Consultant I - Network Security Engineering
$75K - $126K *
Innovate with us to enhance network security platforms, ensuring robust protection and operational efficiency. As a key engineer, you'll tackle complex challenges, automate processes, and collaborate...
2 weeks ago
Global Strategic Partnership Director
$150K - $180K *
Transform global partner strategies to drive revenue and market share through innovative go-to-market models, collaborating with key stakeholders to establish impactful partnerships and optimize sales...
2 weeks ago
Associate Medical Director, Prostate Cancer Theranostics
$175K - $210K *
Drive the execution of a comprehensive medical affairs plan for prostate cancer theranostics, collaborating across functions to enhance strategy, launch readiness, and lifecycle planning while advanci...
2 weeks ago
$80K - $175K *
Lead the charge in driving sales performance and team accountability. Engage directly with agents, manage leads, and foster a high-energy environment to maximize conversions and team growth while ensu...
3 weeks ago
Managing Attorney Central Region
$95K *
Champion impactful legal solutions by leading a team of attorneys in diverse litigation, ensuring effective case management and collaboration with various stakeholders to uphold justice and public ser...
2 weeks ago
$75K - $90K *
Engage with borrowers and partners to drive loan origination success. Build relationships, manage a robust pipeline, and consistently meet targets while navigating the lending landscape to deliver tai...
4 days ago
$100K - $120K *
Inspire growth in real estate financing by driving sales and fostering relationships with investors. Excel in a fast-paced environment as you leverage your expertise to achieve substantial origination...
Reposted 5 days ago
$78K - $88K *
Join us to perform actuarial analyses and support healthcare consulting projects. Collaborate with multidisciplinary teams to develop insights, maintain models, and communicate findings effectively wh...
2 weeks ago
$150K - $220K *
Oversee a specialized team to ensure AI safety in biological research, addressing dual-use risks and providing expert guidance on complex cases while mentoring junior specialists and advising clients...
1 week ago
Senior Regulatory Submissions Lead
$145K *
Drive innovation and transform lives by leading regulatory strategies and submissions for clinical trials globally. Act as a key liaison for project teams to ensure compliance, operational excellence...
Reposted 2 weeks ago
Senior Director, National Field Excellence
$217K - $271K *
Launch your career by owning the national Field Excellence model, managing operations for a groundbreaking oncology therapy. Collaborate with sales leaders to enhance prescriber access and streamline...
2 weeks ago
$95K - $115K *
Join a dynamic team to create impactful visual solutions for healthcare audiences. Collaborate with cross-functional teams to manage creative workflows and elevate brand presence across print and digi...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.