Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Associate Director, Advisor Relations
$145K - $175K *
Champion EPAM's growth by leading Advisor Relations strategy across North America. Build trusted relationships with sourcing advisors to drive commercial opportunities and enhance market perception, a...
5 days ago
Senior Engagement Manager - Medical Affairs
$210K - $258K *
Unlock your potential as a Senior Engagement Manager, leading complex consulting projects for pharmaceutical clients. Drive strategic medical initiatives, foster client relationships, and mentor teams...
Reposted 1 week ago
Founding Enterprise Account Executive, Health Plans
$270K - $340K *
Unlock potential by driving sales for innovative healthcare compliance solutions. Own the full sales cycle with health plans, transforming initial conversations into lasting partnerships while shaping...
Today
$80K - $90K *
Shape the future of integrated marketing strategies by owning the creative process from ideation to execution. Collaborate with teams to deliver impactful campaigns that drive performance and renewals...
Today
Senior Financial Transformation Consultant
$98K - $163K *
Drive your career forward by transforming financial management processes, enhancing operational efficiency, and collaborating with senior stakeholders to implement innovative solutions in a dynamic co...
1 week ago
Senior Technical Solutions Analyst
$100K - $120K *
Champion strategic technology solutions for back-office operations, translating complex business needs into actionable plans. Collaborate with stakeholders to enhance ERP systems, improve processes, a...
Reposted 1 week ago
Senior District Manager (North East)
$155K - $165K *
Shape the future of retail by driving sales and operational excellence across a high-volume district. Lead and develop Store Managers, ensuring brand consistency and delivering exceptional customer ex...
2 weeks ago
Senior Director, North America Compliance
$231K - $301K *
Lead the charge in compliance strategy for U.S. Commercial and Market Access. Collaborate with senior leaders to guide complex compliance issues, manage risks, and support innovative business objectiv...
Reposted today
$80K - $95K *
Lead the charge in shaping HR strategies that enhance organizational effectiveness, drive talent development, and foster a culture of excellence while ensuring compliance and promoting positive relati...
Reposted 3 days ago
Senior Construction Representative-Lexington
$80K - $95K *
Join a team that's dedicated to ensuring construction quality and compliance. Oversee projects, conduct inspections, and collaborate with government personnel to uphold standards in workmanship, mater...
5 days ago
National Accounts Director; Payor Accounts
$220K - $255K *
Shape the future of healthcare by leading strategic payor relationships and driving reimbursement strategies. Collaborate cross-functionally to enhance patient access and optimize coverage for innovat...
3 weeks ago
$128K - $268K *
Empower a high-performing sales team to drive client acquisition and growth in the Middle Market segment, ensuring strong financial performance and fostering trusted advisor relationships with clients...
Yesterday
Director, Business Strategy and Operations, Global Clinical Development Operations (GCDO)
$192K - $288K *
Join us as a strategic partner in global clinical development operations, driving workforce planning, budget management, and continuous improvement initiatives. Collaborate with leadership to enhance...
6 days ago
Sage Intacct Senior Consultant specializing in Sage Construction Management (SCM)
$97K - $158K *
Optimize client success by leading Sage Intacct implementations in the construction sector. Manage multiple projects, ensuring timely delivery and high satisfaction while mentoring team members and en...
Yesterday
$75K - $113K *
Empower patients by coordinating personalized hospice care, assessing needs, and collaborating with a dedicated care team to enhance quality of life and ensure compassionate support throughout the car...
1 week ago
Vice President, Professional Services
$180K - $220K *
Optimize client onboarding and implementation processes by leading a global team, ensuring operational excellence and compliance in a highly regulated environment while driving record growth and enhan...
2 weeks ago
Environmental/Toxic Tort Litigation Attorneys
$100K - $165K *
Drive impactful litigation by leveraging your legal expertise in environmental and toxic tort cases. Collaborate with a dynamic team while gaining hands-on experience in research, drafting, and court...
2 weeks ago
Senior Dealer Relationship Manager (Southeast-based)
$99K - $138K *
Transform dealer relationships in the Southeast by driving retail growth, onboarding partners, and serving as a trusted advisor. Collaborate cross-functionally to enhance dealer experiences and bring...
2 weeks ago
Sr. Design-Build Project Manager
$125K - $150K *
Lead and manage design-build projects, ensuring timely completion within budget while meeting client objectives and contractual obligations. Oversee scope development, financial performance, and compl...
Reposted today
$95K - $115K *
Champion clinical trial success by leading cross-functional teams, ensuring timely project execution, and maintaining high standards of quality and compliance. Collaborate with stakeholders to drive i...
Today
Specialist Manager, Government Client Contracts Management (Air Force)
$93K - $191K *
Manage strategic federal contract administration activities, advising on contract strategy and execution. Lead negotiations and coordinate with stakeholders to ensure compliance and optimize performan...
1 week ago
Specialist Manager, Government Client Contracts Management (Air Force)
$93K - $191K *
Transform federal contract management by leading strategic initiatives, ensuring compliance, and driving negotiations across complex engagements to enhance revenue retention and operational success...
1 week ago
$90K - $120K *
Elevate your career by leading clients through the CMMC 2.0 compliance journey. As a key advisor, you'll translate complex regulations into actionable strategies, ensuring audit readiness and security...
3 weeks ago
Director, Quality Intelligence & Causal Analysis
$200K - $240K *
Optimize quality intelligence and root cause analysis initiatives to enhance audit quality. Lead data-driven insights and predictive risk assessments, collaborating with stakeholders to identify trend...
1 week ago
$120K - $145K *
Help us shape the future of financial planning and analysis in a dynamic SaaS environment. Drive forecasting, budgeting, and KPI reporting while collaborating across teams to support growth and M&A in...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.