Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Principal Solutions Architect (Federal Civilian Growth)
$200K - $250K *
Join us in shaping technical strategies and growth initiatives for federal opportunities. Collaborate across teams to develop compelling solutions that drive success in complex pursuits, ensuring alig...
Reposted 6 days ago
$90K - $100K *
Join a dynamic team as you craft precise architectural specifications, collaborating with architects to ensure high-quality project documentation and stay ahead of industry trends. Elevate your career...
2 weeks ago
$80K - $95K *
Join a team that's shaping the future of utility-scale transmission projects. Oversee contractor activities, ensure quality installations, and foster strong relationships while managing project logist...
1 week ago
Senior Cost Manager / Quantity Surveyor - Life Sciences Construction
$110K - $130K *
Elevate project success by managing costs for complex Life Sciences construction initiatives. Collaborate with multidisciplinary teams, ensuring client objectives are met through effective cost manage...
5 days ago
Senior Consultant, Patient Experience
$126K - $153K *
Champion transformative patient experiences by leading strategic consulting engagements, collaborating with C-suite leaders, and driving measurable improvements in healthcare delivery and client relat...
Reposted yesterday
Senior Director, Corporate Sales
$212K - $270K *
Drive growth and strategy as a Senior Director, leading a high-performing sales team to achieve exceptional results in a dynamic, fast-paced environment focused on new business and expansion across di...
3 weeks ago
$160K - $200K *
Transform security architecture by defining standards, leading reviews, and managing risks. Collaborate with teams to ensure secure, efficient integration of applications and AI, while maintaining cle...
1 week ago
Compliance Analyst II, Producer Oversight and Suitability Programs - Remote
$72K - $121K *
Join a team that's dedicated to promoting compliance while leading project initiatives. Collaborate across departments as a functional expert to establish policies and monitor compliance with regulato...
Reposted 3 weeks ago
$75K - $109K *
Advance the future of Building Information Modeling by leading BIM strategies, ensuring model quality, and mentoring teams. Drive innovation through technology initiatives and enhance project delivery...
1 week ago
$100K - $120K *
Drive project success by managing complex engineering assignments, ensuring quality delivery while fostering client relationships and supporting business development efforts across multiple teams and...
2 weeks ago
$100K - $140K *
Join a team that's dedicated to delivering exceptional hospice care while shaping strategy and optimizing operations. Lead with compassion and drive results in a fast-paced environment focused on pati...
4 days ago
$110K - $130K *
Drive innovative solutions by leveraging data analytics and strategic counsel to enhance client performance. Collaborate with high-performing teams to deliver tailored insights for transformational ev...
2 weeks ago
Senior Product Marketing Manager
$120K - $145K *
Elevate your career by leading strategic product marketing initiatives, managing high-impact projects, and collaborating cross-functionally to drive value propositions in enterprise technology, includ...
4 weeks ago
$100K - $120K *
Lead the charge in advancing small animal veterinary care, focusing on exotic and avian medicine. Collaborate with a dedicated team to provide exceptional service and mentorship while enjoying a suppo...
Yesterday
$90K - $95K *
Unlock potential by developing financial models and analytics to enhance pricing strategies, analyze firm data, and support partners in maximizing profitability through effective fee arrangements and...
6 days ago
Sr. Clinical Project Research Manager - Oncology Phase 3 Study
$110K - $130K *
Deliver impactful project leadership by guiding cross-functional teams through all phases of clinical research, ensuring compliance, effective communication, and timely project milestones that enhance...
Reposted today
Clinical Lead - Senior Site Activation Lead
$116K *
Drive impactful site activation strategies, collaborating with cross-functional teams to ensure timely delivery of clinical projects while enhancing communication and mitigating risks throughout the p...
1 week ago
Principal Strategic Researcher
$173K - $290K *
Join a team that's redefining strategic research by tackling complex, ambiguous challenges. Collaborate with product, design, and engineering leaders to shape impactful insights that drive business de...
3 weeks ago
$115K - $130K *
Reimagine tax management by joining a dynamic team focused on high-net-worth clients. Collaborate with financial advisors to deliver exceptional service, tackle complex tax issues, and thrive in a fas...
6 days ago
$110K - $130K *
Join a team that's shaping the future of claims management for Non-Profits. Lead and mentor a skilled team, providing strategic direction on complex claims while ensuring exceptional service and compl...
4 weeks ago
$130K - $180K *
Lead enterprise IT initiatives by assessing environments, developing solution architectures, and overseeing implementations. Collaborate with stakeholders to ensure alignment with organizational stand...
1 week ago
$110K - $130K *
Advance product development by collaborating with cross-functional teams to manage lifecycles, ensure compliance, and drive technology innovations for enhanced customer experience and market competiti...
Reposted 4 weeks ago
$130K - $165K *
Empower growth by leading strategic partnerships in the insurance sector. Drive revenue and client retention through innovative solutions and deep industry insights, while managing complex sales cycle...
Yesterday
$91K - $109K *
Lead the charge in maintaining financial integrity by overseeing accounting operations, ensuring compliance with nonprofit standards, and managing audits. Collaborate with finance leadership to produc...
Reposted 4 days ago
$40K - $200K *
Join a dynamic team to drive business growth through consultative sales, building lasting client relationships, and delivering innovative payment solutions. This role offers uncapped earnings and oppo...
4 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.