Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Portfolio Manager-Syndications
$81K - $120K *
Help us elevate our Syndications platform by managing portfolios, structuring transactions, and collaborating with internal and external partners to drive growth and efficiency in syndicated deals...
1 week ago
Director, Commercial Mortgage Loans
$126K - $188K *
Join a dynamic team to evaluate and manage commercial mortgage investments, collaborating with developers and brokers. Drive underwriting, pricing, and closing processes while supporting asset managem...
3 weeks ago
Senior Compliance Program Manager, GRC
$120K - $140K *
Drive compliance excellence as a Senior Compliance Program Manager, overseeing complex initiatives across enterprise and federal environments. Collaborate with cross-functional teams to ensure audit r...
3 weeks ago
Commercial Liability Claim Adjuster
$80K - $93K *
Join a team that's dedicated to managing complex commercial liability claims. You'll negotiate settlements, investigate coverage, and ensure compliance while maintaining high standards in a fast-paced...
2 weeks ago
$125K - $170K *
Lead the charge in managing complex contracts for a major program, ensuring compliance and strategic alignment. Collaborate with teams to develop proposals, negotiate terms, and maintain strong relati...
2 weeks ago
Attorney I - Prosecuting Attorney
$68K - $98K *
Drive justice by representing the County in criminal prosecutions, managing cases from charge determination to court presentation, while collaborating with law enforcement and ensuring ethical standar...
4 weeks ago
Senior Compliance Oversight Specialist (RN)
$92K - $110K *
Champion compliance excellence by overseeing audits and monitoring activities. Collaborate with teams to ensure adherence to regulatory standards and drive remediation efforts, enhancing integrity acr...
Today
$110K - $130K *
Champion clinical trial excellence by managing projects from initiation to completion, ensuring compliance and quality standards while collaborating with cross-functional teams to drive successful out...
1 week ago
$80K - $95K *
Empower client success by leading integrated marketing campaigns, managing key accounts, and driving strategic growth. Collaborate with cross-functional teams to deliver impactful solutions while ment...
1 week ago
Regulatory Claims Substantiation Specialist
$103K - $120K *
Advance your career by reviewing and revising scientific claims for dietary supplements. Collaborate with cross-functional teams to ensure compliance and support product development while managing mul...
3 weeks ago
Private Client Advisor - Commerce Trust
$72K - $163K *
Empower high-net-worth clients by delivering tailored wealth management solutions, managing fiduciary and investment relationships, and collaborating with professional advisors to achieve comprehensiv...
2 weeks ago
Senior Director, Analytical Development
$230K - $280K *
Champion analytical development by leading strategy and execution for pipeline products. Drive compliance and quality control while building a high-performing team in a dynamic environment focused on...
Today
Senior Project Manager - Structural
$110K - $130K *
Empower your career by leading complex engineering projects, driving innovation, and building strong client relationships. Utilize your expertise to mentor teams and enhance organizational capabilitie...
2 weeks ago
$120K - $145K *
Shape the future of cyber claims management by leading a dynamic team, driving strategic initiatives, and ensuring exceptional service delivery while adhering to industry standards and regulatory requ...
2 weeks ago
Senior Project Manager, Campaign Operations
$180K - $200K *
Manage the campaign calendar and ensure timely launches by transforming customer requests into actionable specs. Collaborate with cross-functional teams to maintain project alignment and drive success...
2 weeks ago
Remote Medical Director, Appeals
$215K - $408K *
Lead the charge in medical management and quality improvement initiatives, ensuring optimal care delivery and cost-effectiveness. Collaborate with clinical teams to enhance utilization management and...
3 weeks ago
$156K - $255K *
Partner with us to drive revenue growth by engaging in sales pursuits, demonstrating business value, and advising teams on value management principles to ensure successful customer outcomes and impact...
3 weeks ago
Major Accounts Executive, South Central
$150K - $180K *
Partner with us to drive growth in strategic enterprise accounts, managing complex sales cycles and building trust with security-focused buying committees. Leverage technical credibility to close mult...
2 weeks ago
$125K - $150K *
Lead the development of AI-driven data solutions to optimize business operations. Collaborate with stakeholders to enhance digital transformation initiatives in underwriting and claims functions, driv...
Reposted 3 days ago
Associate Director, Insurance Compliance
$120K - $145K *
Drive compliance excellence by leading insurance operations, optimizing processes, and mitigating risks across a commercial loan servicing portfolio while ensuring adherence to regulatory and investor...
1 week ago
Dir, Thought Leader Liaison (Oncology)
$203K - $245K *
Unlock potential by leading a national team of Thought Leader Liaisons to enhance KOL engagement and advocacy in oncology. Drive strategic initiatives, foster collaboration, and ensure compliance whil...
Reposted 1 week ago
$90K - $110K *
Engage with clients, driving success in digital campaign execution. Become an expert in programmatic advertising processes, enhancing customer satisfaction through effective communication and collabor...
Reposted 3 weeks ago
Head of Business Risk & Controls
$180K - $200K *
Lead the development of a robust risk and control framework, ensuring effective identification and management of risks in fiduciary and regulated financial services. Collaborate with stakeholders to e...
3 weeks ago
Sr. Client Partner (Insurance) - West Coast & Chicago
$150K - $180K *
Engage with key Insurance clients to drive strategic growth and account management. Leverage your expertise in business development and executive relationships to expand enterprise accounts across the...
2 weeks ago
$80K - $121K *
Lead impactful training initiatives designed to empower customers globally. Utilize innovative methods and foster strong relationships to enhance learning experiences and drive success across diverse...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.