Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$250K - $325K *
Accelerate your career by leading strategic communications and public policy initiatives that shape the future of AI identity and accountability. Drive visibility, influence industry narratives, and b...
5 days ago
$120K - $192K *
Join our dynamic team to manage M&A due diligence engagements, providing insights for financial strategies. Collaborate with senior leadership, lead analyses, and mentor junior staff while driving imp...
Reposted 3 weeks ago
Strategic Partnerships Manager
$160K - $190K *
Engage in building strategic partnerships that drive revenue growth. Collaborate with global tech partners to ensure effective integration and delivery. Lead initiatives that enhance the operational l...
Reposted 4 days ago
Senior Regulatory Affairs Consultant - Regulatory Project Manager
$120K - $145K *
Join a team that shapes global regulatory strategy in a fast-paced environment. You will lead comprehensive regulatory plans, ensuring alignment and execution from development to post-marketing, impac...
Reposted 1 week ago
$65K - $108K *
Unlock potential by providing advanced technical support and engineering expertise to resolve complex production issues. Manage end-to-end case ownership while collaborating with teams to enhance serv...
3 weeks ago
Regional Vice President, New Client Development
$225K - $250K *
Unlock new client potential by leading financial advisory teams to acquire high-net-worth clients. Drive business growth through strategic marketing and relationship building, ensuring exceptional ser...
3 weeks ago
Senior Computer Systems Engineer/Architect - Informatica
$170K - $210K *
Lead the design and implementation of cross-platform solutions in AWS GovCloud, focusing on Informatica architecture, security, and CI/CD practices. Collaborate with multidisciplinary teams to ensure...
1 week ago
$100K - $120K *
Drive new dealer acquisition by managing the full sales cycle, building strong relationships, and executing strategic territory plans to achieve sustainable revenue growth in a competitive automotive...
2 weeks ago
$112K - $131K *
Elevate your career by leading complex financial analyses and strategic initiatives. As a senior contributor, you'll drive enhancements in reporting, support business decisions, and mentor team member...
3 weeks ago
$110K - $140K *
Join a team that's dedicated to designing and implementing resilient infrastructure solutions that enhance operational readiness and supportability while aligning with enterprise architecture standard...
6 days ago
$110K - $130K *
Join a dynamic team to lead tax engagements, consult on planning, and develop talent. Shape client success through strategic management and industry expertise while fostering a collaborative environme...
2 weeks ago
$110K - $130K *
Advance client success by leading tax engagements, mentoring teams, and driving strategic solutions. Leverage your expertise to enhance business processes and foster growth in a collaborative environm...
2 weeks ago
$126K - $154K *
Unlock your potential as a Senior Accountant, driving financial accuracy and compliance. Collaborate across teams to enhance systems, oversee key accounting functions, and support audits in a dynamic...
1 week ago
General Manager, Mergers & Acquisitions
$170K - $205K *
Drive the integration and growth of a newly acquired business, overseeing P&L, client relationships, and operations. Collaborate with teams to ensure seamless transition and performance against revenu...
3 weeks ago
Associate Clinical Oncology Specialist
$80K - $100K *
Join a dynamic team as you enhance patient outcomes in Oncology. Contribute to sales and support activities, build key relationships, and optimize clinical workflows while driving patient retention an...
2 days ago
Senior Consultant - Clinical Operations
$89K - $148K *
Drive your career with impactful consulting in healthcare, enhancing operational efficiency and financial performance for provider organizations through data analysis and project management...
1 week ago
Counsel, Regulatory (Pharmacy)
$120K - $145K *
Join a dynamic Legal team to provide actionable regulatory advice across pharmacy laws, impacting healthcare and e-commerce. Collaborate with diverse business units to navigate complex legal landscape...
5 days ago
$125K - $150K *
Transform enterprise data governance by leading strategy, enhancing quality, and ensuring responsible use. Collaborate with senior leaders to integrate governance into priorities and drive measurable...
Yesterday
$110K *
Join a dynamic team as you oversee a 3PL distribution warehouse, ensuring safety and efficiency while managing operations, budgets, and staff. Drive excellence in customer service and lead a dedicated...
Reposted today
Accounts Payable Manager (North America)
$80K - $95K *
Join a team that's dedicated to enhancing the Accounts Payable process, driving operational excellence, and fostering high-performing teams. Collaborate across functions to support scalable growth and...
Reposted 2 weeks ago
$125K - $150K *
Drive enterprise growth by strategically engaging high-value accounts, orchestrating complex sales processes, and leveraging AI capabilities to enhance compliance workflows. Build executive relationsh...
5 days ago
$100K - $120K *
Lead the charge in tax management by preparing and reviewing complex returns, guiding a skilled team, and delivering exceptional client service while assuming responsibility for a diverse range of tax...
Reposted 3 weeks ago
Technical Claim Manager-Miscellaneous Professional Liability/Errors & Omissions (E&O)
$100K - $143K *
Lead the management of professional liability claims from inception to resolution, ensuring thorough investigation and effective outcomes while collaborating with various stakeholders to optimize clai...
1 week ago
Director, Strategy and Analytics - Wealth Solutions
$150K - $180K *
Transform client insights into strategic growth by leveraging your analytical acumen to enhance revenue and operational effectiveness. Collaborate with teams to drive informed decisions and present im...
Reposted 3 weeks ago
Senior Advisor, Federal Contracts - Evernorth Federal Services - Hybrid (MO)
$100K - $120K *
Transform federal contract administration by providing expert guidance and support throughout the acquisition lifecycle, ensuring compliance and efficiency while collaborating with cross-functional te...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.