Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$100K - $185K *
Unlock business growth by leading technical scoping, managing client relations, and guiding consultants. This hybrid role integrates project management with hands-on consulting to ensure accurate prop...
Reposted 4 weeks ago
Direct of Strategic Sales- PR/ Comms/ Media
$119K - $221K *
Advance your career by driving strategic sales initiatives within large enterprises. Collaborate with cross-functional teams to exceed sales quotas and develop innovative solutions that meet client ne...
5 days ago
$100K - $120K *
Drive impactful manager research for Mutual Funds, SMAs, and ETFs, contributing to the management of $9 billion in client assets. Collaborate with investment professionals and leverage AI tools to enh...
1 week ago
Unit Manager - Retirement New Business - Remote
$66K - $110K *
Elevate your career by leading a dynamic team in retirement operations. Drive performance, enhance customer experiences, and implement process improvements while fostering a collaborative environment...
4 days ago
$110K - $130K *
Transform healthcare operations as a Regional Operating Officer, leading teams to enhance patient services, drive strategic initiatives, and foster community partnerships. This executive role demands...
2 weeks ago
$120K - $145K *
Optimize runtime authorization strategies across diverse segments, driving technical wins and enabling Sales Engineers. Leverage deep IAM and PAM expertise to deliver impactful solutions, ensuring com...
2 weeks ago
Sr Area Business Director, West
$160K - $190K *
Lead the charge in driving growth by managing a high-performing sales team, collaborating across functions, and executing strategic initiatives to enhance commercial success in the Hematology sector...
6 days ago
$88K - $115K *
Analyze compensation strategies and drive data-informed decisions to enhance pay equity and market competitiveness. Collaborate with HR and business leaders to optimize compensation programs and suppo...
Today
$88K - $115K *
Analyze and enhance compensation programs through data-driven insights, collaborating with HR and business leaders to ensure competitive and equitable pay practices aligned with organizational goals...
Today
Vice President, CMC Regulatory Affairs
$272K - $340K *
Elevate your career by leading CMC Regulatory strategy and execution. Drive submissions, build a high-performing team, and engage with global health authorities to ensure compliance and success in dru...
2 weeks ago
$70K - $91K *
Engage with healthcare professionals to advocate for patients during pre-admission. Utilize clinical expertise to assess needs, coordinate care plans, and facilitate smooth transitions to specialized...
Today
$70K - $91K *
Unlock potential by advocating for patients and coordinating care plans with clinical teams. Collaborate with healthcare professionals to ensure seamless transitions for patients post-ICU, enhancing t...
Yesterday
$120K - $145K *
Champion innovative solutions by collaborating with clients to align IT capabilities with business goals. Leverage your expertise in enterprise architecture to drive strategic initiatives and optimize...
3 weeks ago
Complex Claim Specialist, New York Labor Law
$135K - $165K *
Tackle complex general liability claims by evaluating coverage issues, managing risks, and formulating resolution strategies. Collaborate with internal and external parties to ensure effective investi...
Yesterday
AI Consulting Engineer - Senior Associate
$85K - $161K *
Elevate enterprise AI solutions by deploying, securing, and scaling AI assistants. Collaborate with clients to ensure readiness and optimize their AI journey from experimentation to production, enhanc...
5 days ago
AI Transformation Lead - Global Legal & Compliance
$135K - $160K *
Lead the charge in shaping GL&C's AI strategy and roadmap, driving cross-functional initiatives to enhance productivity and governance while ensuring alignment with strategic business priorities for 2...
2 days ago
$110K - $130K *
Lead feasibility strategy and execution for clinical studies, driving operational excellence and data-driven insights to optimize trial planning and enrollment across rare disease programs. Collaborat...
1 week ago
$191K - $305K *
Champion innovative healthcare solutions by leveraging clinical expertise to enhance value-based strategies, drive operational excellence, and foster strategic partnerships for improved member care an...
4 weeks ago
Senior Analyst, Asset Based Lending Field Exam
$95K - $115K *
Lead the future of asset-based field examinations by delivering insightful analyses, evaluating financial controls, and ensuring compliance. Collaborate with clients to assess collateral values and mi...
1 week ago
Senior Account Manager, Med Affairs
$90K - $105K *
Collaborate with clients and teams to manage projects, expectations, and delivery, ensuring high standards and strategic growth in a fast-paced medical affairs environment. Leverage experience to iden...
Reposted 2 weeks ago
Senior Analyst, Client Insights
$124K - $145K *
Join our Client Insights team to transform data into actionable insights that drive sales and merchant retention. Collaborate across analytics, product, and strategy to enhance AI-driven solutions for...
2 weeks ago
Senior Manager - State Government Relations and Public Affairs
$80K - $145K *
Unlock potential by driving strategic government relations across the Midwest. Build and maintain key relationships with legislators and stakeholders to ensure Covista's success in navigating the legi...
1 week ago
$75K - $90K *
Unlock potential by leading accounting services for diverse clients, managing month-end closings, and mentoring junior staff. Utilize your expertise to build client relationships and drive operational...
5 days ago
Senior Director, Early Oncology
$230K - $345K *
Transform clinical trial management by leading early-phase oncology programs. Drive strategic vision, operational excellence, and cross-functional collaboration to ensure timely, budget-compliant exec...
5 days ago
$122K - $261K *
Elevate employee experiences by leading digital transformation initiatives, providing strategic guidance, and implementing scalable solutions across enterprise environments to enhance productivity and...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.