Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Practice Manager - Ear, Nose and Throat Surgery Clinic - FT
$80K - $95K *
Lead the charge in enhancing patient care and operational excellence across ENT, Head & Neck Surgery, and Audiology clinics. Drive efficiency, foster teamwork, and support caregivers in a dynamic, mul...
1 week ago
Associate Attorney- Relocation Required
$200K - $400K *
Launch your legal career by advocating for injured clients in a collaborative team environment. Utilize your expertise in personal injury or insurance defense to maximize client recovery and make a me...
Today
Principal Attack Engineer, AI/LLM
$238K - $280K *
Shape the future of AI/LLM security by leading innovative offensive strategies, defining technical vision, and driving cross-company initiatives to enhance NodeZero's capabilities in identifying and e...
4 days ago
Senior Account Executive - SMB SaaS
$70K - $115K *
Join a team that's transforming food safety compliance through innovative SaaS solutions. As a Senior Account Executive, you'll drive sales growth by managing the full sales cycle and building strong...
1 week ago
Governance, Risk and Compliance Lead
$132K - $156K *
Unlock potential by leading governance, risk, and compliance initiatives. Collaborate with cross-functional teams to optimize processes, manage projects, and enhance training programs while ensuring e...
Yesterday
Fiduciary Risk Specialist (Trust Examiner)
$90K - $155K *
Join a dynamic team to evaluate fiduciary risk management and compliance in financial organizations. Lead examinations, assess operational risks, and communicate findings to enhance oversight and ensu...
2 weeks ago
$110K - $130K *
Join us to lead the development and execution of clinical study designs, ensuring effective project management and collaboration across teams. Your expertise will drive the success of clinical trials...
3 weeks ago
Sales Enablement Principal - Governance, Risk, and Compliance
$154K - $265K *
Join a team that's redefining sales enablement by leveraging deep expertise in Governance, Risk, and Compliance. Drive impactful solutions that empower sellers to engage effectively with diverse custo...
Today
Senior Account Manager, Promotional Medical Education
$85K - $95K *
Transform client relationships by leading strategic projects, ensuring quality and alignment across teams. Collaborate with stakeholders to drive success and meet client expectations while fostering g...
2 weeks ago
Senior Underwriting Consultant - Life Underwriting - Remote
$106K - $177K *
Lead complex underwriting decisions for high-net-worth and foreign national clients. Collaborate with teams to assess risks, build relationships, and enhance processes while mentoring others in a dyna...
2 weeks ago
Sr. Sales Director (IT Managed Services)
$150K - $180K *
Accelerate progress at building strategic client partnerships through consultative sales. Lead the full sales cycle for managed services, engaging executives to drive recurring revenue and operational...
2 weeks ago
Sr. Sales Director (IT Managed Services)
$150K - $180K *
Shape your career by driving managed services sales, engaging executives, and building long-term client partnerships. Leverage a Microsoft-aligned portfolio to create value through consultative sellin...
2 weeks ago
$80K - $95K *
Empower your career as a Data Advisor, driving data integrity and operational excellence in security reference data and pricing. Collaborate across teams to enhance processes and support strategic ini...
5 days ago
Senior Sourcing Manager (Contract Negotiator)
$110K - $130K *
Champion strategic sourcing initiatives by negotiating complex vendor contracts, collaborating across business units, and driving cost-effective solutions that align with organizational goals while fo...
1 week ago
Director, Centralized Case Management
$110K - $130K *
Elevate your career by providing strategic leadership for a national remote case management team, ensuring service excellence, operational consistency, and client satisfaction while collaborating with...
4 weeks ago
Global Alliance Operations Director
$75K - $180K *
Lead the coordination of joint sales initiatives with Adobe for strategic clients. Ensure efficient collaboration among teams, manage project execution, and foster strong relationships to drive operat...
Reposted today
Lead Analyst, Independent Dispute Resolution (IDR)
$88K - $105K *
Shape the future of healthcare revenue management by leading IDR processes, ensuring compliance, and driving data-informed improvements while mentoring a team of analysts to optimize workflows and enh...
Reposted 4 days ago
$93K - $150K *
Drive impactful market research initiatives by leading client relationships, managing complex projects, and mentoring teams. Collaborate with stakeholders to deliver strategic insights that enhance de...
1 week ago
Senior Operational Risk Manager
$179K - $249K *
Lead the charge in shaping and executing the Operational Risk program, collaborating with key teams to enhance risk management practices and reporting as the organization transitions to banking operat...
3 weeks ago
Senior Director of Strategic Planning and Analysis
$185K - $315K *
Join us to shape strategic financial planning and analysis, leveraging AI to enhance forecasting and decision-making. This high-impact role collaborates with executives, driving insights that align wi...
5 days ago
Product Business Support Specialist
$83K - $140K *
Join a dynamic team to drive insurance product design and implementation. Collaborate cross-functionally to manage projects, ensuring alignment with strategic goals while facilitating effective busine...
2 weeks ago
$100K - $185K *
Unlock business growth by leading technical scoping, managing client relations, and guiding consultants. This hybrid role integrates project management with hands-on consulting to ensure accurate prop...
Reposted 4 weeks ago
Direct of Strategic Sales- PR/ Comms/ Media
$119K - $221K *
Advance your career by driving strategic sales initiatives within large enterprises. Collaborate with cross-functional teams to exceed sales quotas and develop innovative solutions that meet client ne...
5 days ago
$100K - $120K *
Drive impactful manager research for Mutual Funds, SMAs, and ETFs, contributing to the management of $9 billion in client assets. Collaborate with investment professionals and leverage AI tools to enh...
1 week ago
Unit Manager - Retirement New Business - Remote
$66K - $110K *
Elevate your career by leading a dynamic team in retirement operations. Drive performance, enhance customer experiences, and implement process improvements while fostering a collaborative environment...
4 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.