Grasp unique opportunities in the scientific realm by exploring high-paying Principal Scientist jobs that offer annual remuneration of over $100,000. Broaden your professional horizons and get closer to your career goals with our advanced search tools for Principal Scientists.
As a Principal Scientist, you will lead innovation, drive scientific research, and contribute to the growth of the scientific community at large. It is a role that combines leadership, in-depth scientific knowledge, and impactful decision-making.
We provide comprehensive job listings, insightful articles, growth opportunities, and a diverse range of resources for Principal Scientists looking to make their next career move.
Principal Scientist/Senior Principal Scientist, Process Chemistry
$120K - $145K *
Lead cross-functional teams to innovate and optimize complex chemical processes, driving projects from candidate identification to commercial transfer while ensuring compliance and sustainability in a...
Reposted 3 weeks ago
Senior Scientist - Pharmaceutical Materials Scientist
$100K - $120K *
Transform pharmaceutical research by driving innovative solid-state characterization and crystallization for advanced bRo5 molecules, collaborating across disciplines to enhance drug delivery and deve...
3 weeks ago
Principal Scientist, Commercial and Late-Stage Purification Process Development
$159K - $207K *
Drive innovative downstream purification processes for commercial biologics, ensuring technical alignment across manufacturing sites while supporting lifecycle management and regulatory updates for la...
Reposted 1 week ago
Principal Scientist - Radio Frequency Plasma Heating
$150K - $225K *
Lead the charge in experimental RF science to optimize the operation and commissioning of advanced ion cyclotron heating systems in plasma physics, supporting innovative fusion energy research and mul...
3 weeks ago
Senior Scientist (Drug Metabolism & Pharmacokinetics)
$124K - $230K *
Join a dynamic team to lead DMPK strategies, oversee studies, and drive drug development decisions for small molecules in a collaborative environment.
3 weeks ago
Principal Scientist, Pharmaceutical Analytical Sciences
$156K - $247K *
Drive innovation in analytical methodologies for pharmaceuticals, leading cross-functional teams to develop drug products from conception to commercialization while ensuring regulatory compliance and...
Reposted today
Senior Scientist, Engineering- Lab Start-Up and Commercialization
$117K - $184K *
Lead the charge in establishing lab capabilities and optimizing biologics conjugation processes, ensuring compliance and efficiency while advancing team collaboration and continuous improvement throug...
Today
$80K - $95K *
Elevate product development by executing quality improvement initiatives and innovating beverage formulations. Collaborate cross-functionally to optimize processes, leveraging scientific methods and t...
1 week ago
Senior Principal Scientist, Applied AI & Agentic Systems for Small-Molecule Drug Discovery
$168K - $252K *
Pioneer AI-driven advancements in drug discovery, enhancing scientific workflows and decisions across projects. Collaborate with teams to implement computational solutions and strategies that improve...
2 weeks ago
Principal Scientist, LNP Platform & Process Development
$169K - $185K *
Tackle complex challenges by leading LNP formulation and process development, optimizing mRNA delivery systems for a groundbreaking CAR-Treg platform, driving innovation from research to scalable prod...
2 weeks ago
$100K - $110K *
Discover innovative ways to advance continuous flow chemistry solutions and enhance our proprietary technologies while collaborating with a team of talented scientists in a fast-paced environment...
3 weeks ago
Principal Scientist, Formulation & Drug Product Development
$159K - $207K *
Join a team that's redefining the biotherapeutics landscape by leading formulation and drug product development for innovative protein biologics, ensuring product quality through comprehensive researc...
5 days ago
Senior Scientist, Materials Science
$117K - $184K *
Join a team that's dedicated to transforming pharmaceutical materials science. Collaborate across disciplines to tackle challenges in material characterization, enhancing drug efficacy from discovery...
Today
$86K - $108K *
Empower the advancement of AI and analytics solutions across various sectors, driving innovation in manufacturing and enterprise workflows for optimal efficiency and digital transformation...
2 weeks ago
$86K - $108K *
Drive transformative AI solutions across multiple business roles, leveraging advanced analytics and innovative technologies to enhance processes, improve decision-making, and foster collaboration for...
2 weeks ago
$86K - $108K *
Unlock potential by designing and deploying innovative AI solutions that drive digital transformation across manufacturing, quality, and supply chain sectors, while collaborating with cross-functional...
3 weeks ago
$95K - $115K *
Unlock potential by leading the development of innovative confectionery VMS and OTC products while mentoring junior scientists. Collaborate across teams to drive new opportunities, enhance product for...
3 weeks ago
$105K - $139K *
Shape the future of bioanalytical processes by developing and optimizing LC-MS/MS methods, mentoring team members, and managing client relations to deliver top-quality data in a dynamic CRO environmen...
Reposted 3 days ago
$117K - $184K *
Innovate sterile drug product processes for late-stage drug commercialization. Lead process development, ensuring robust manufacturing strategies and regulatory compliance while supporting diverse pro...
1 week ago
Principal Scientist, Chemical Development
$165K - $185K *
Lead impactful drug development by architecting scalable synthetic processes, ensuring safe and efficient multi-kilogram manufacturing while collaborating with cross-functional teams to meet preclinic...
4 days ago
Senior Scientist, Operations Investigation Team (OIT) #4936
$122K - $147K *
Transform your career by driving scientific investigations and data-driven solutions in a collaborative environment. Utilize your expertise in molecular biology and assay development to enhance platfo...
3 weeks ago
Principal Scientist - NGS/Genomics and Bioinformatics
$130K - $160K *
Lead the design and execution of NGS sequencing platforms, mentoring teams and driving multi-omics integration with genomics and proteomics technology. Shape laboratory strategy to deliver innovative...
Reposted 1 week ago
Principal Clinical Technical Specialist
$110K - $130K *
Engage in quality assurance by reviewing clinical records for compliance with service protocols and regulations. Collaborate with multiple teams to ensure optimal handling of complaints and installati...
1 week ago
$110K - $130K *
Join a team that's dedicated to advancing cytogenetic testing technologies. Drive scientific innovation and ensure technical excellence while overseeing research and development activities within a co...
3 weeks ago
Principal R&D Engineer/Scientist
$180K - $245K *
Advance your career by leveraging your expertise in polyurethane and polyisocyanurate foam technologies. Collaborate with cross-functional teams to drive innovation and enhance customer engagement whi...
4 days ago
What is the role of a Principal Scientist?
A Principal Scientist typically leads scientific research, explores innovative ideas, and guides a team of scientists towards achieving the organization's scientific goals.
How much does a Principal Scientist earn on average?
The average salary of a Principal Scientist varies depending on the industry and level of experience. However, on Ladders, you can find Principal Scientists jobs that pay over $100,000.
What qualifications are required for Principal Scientist jobs?
Most Principal Scientist roles require at least a Ph.D. in a relevant scientific field along with several years of research experience. Leadership skills and a proven research track record are typically also essential.
Can I find remote Principal Scientist jobs on Ladders?
Yes, on Ladders, you can find both remote and in-office high-paying Principal Scientist jobs.