Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Senior Product Marketing Manager (US)
$120K - $145K *
Unlock potential by leading product marketing strategies for developer-facing solutions. Collaborate across teams to enhance messaging, drive customer engagement, and ensure successful deployments, al...
1 week ago
$90K - $115K *
Join a dynamic team as a Senior Project Planner, driving financial health and vendor coordination across multiple brands while ensuring project success through strategic planning and effective communi...
1 week ago
$150K - $180K *
Lead the design and implementation of scalable ML systems, bridging business strategy with technical execution. Drive impactful data solutions, mentor teams, and ensure robust model performance to enh...
2 days ago
$186K - $252K *
Shape the future of AI in cybersecurity by designing and delivering advanced LLM and agentic AI systems. Collaborate across teams to establish best practices, mentor engineers, and translate customer...
1 week ago
Senior Technical Program Manager, Partner Ecosystem
$125K - $150K *
Champion the technical integration of partner ecosystems, ensuring seamless onboarding and operational reliability. Drive API discovery, documentation, and troubleshooting while collaborating with int...
3 days ago
Senior/Staff Software Engineer (Platform and Execution Model)
$180K - $240K *
Transform the future of distributed systems by designing and building robust platform components. Collaborate with teams to ensure reliability and scalability in mission-critical environments, driving...
4 weeks ago
Principal Analytics Consultant (Power BI)
$135K - $160K *
Lead complex Power BI analytics engagements, delivering data-driven solutions that enhance decision-making, foster stakeholder alignment, and support sustained enterprise adoption. Collaborate with cr...
Reposted 3 weeks ago
Senior Program Manager, Application Security
$125K - $150K *
Lead the charge in transforming enterprise security implementations into measurable success. Drive customer outcomes, manage complex programs, and build trusted relationships with executives to ensure...
3 days ago
Senior Medical Safety Specialist
$107K - $160K *
Lead the charge in enhancing patient safety by providing clinical expertise and oversight across cardiac ablation technologies. Collaborate with cross-functional teams to evaluate safety signals and s...
3 days ago
Senior Forward Deployed Engineer (FDE)
$170K - $205K *
Join a dynamic team to lead AI agent deployments in healthcare. Leverage your software engineering expertise and client-facing skills to drive technical delivery, influence product development, and en...
2 weeks ago
Process Excellence Lead, Payments
$125K - $172K *
Explore a pivotal role in global Payments process excellence, driving standardization, governance, and continuous improvement. Collaborate with diverse teams to enhance payment operations and optimize...
2 days ago
Director, Group Leader, BeOne Institute - San Carlos, California
$236K - $295K *
Lead the charge in advancing breakthrough discoveries by guiding a high-performing research team. Set strategic goals, foster collaboration, and translate innovative ideas into transformative medicine...
4 weeks ago
Senior Director, Regulatory Affairs CMC
$222K - $303K *
Champion regulatory excellence by leading CMC strategies for global drug approvals. Collaborate across teams to navigate complex regulations, ensuring compliance and successful product lifecycle manag...
Reposted 6 days ago
Project Manager - Capital Planning
$90K - $120K *
Optimize building assessments and capital projects while leading teams and managing client relationships. Oversee project scopes, budgets, and timelines to deliver impactful outcomes in a collaborativ...
Reposted 6 days ago
Forward Deployed Solution Engineer - Applied AI FDE
$201K - $352K *
Join a team that's redefining enterprise AI by building scalable, LLM-enabled applications. Collaborate with customers to deliver impactful solutions, codify reusable assets, and shape the future of A...
4 weeks ago
Director, Market Access & Government Affairs
$190K - $200K *
Strategize market access initiatives to enhance patient access and reimbursement. Oversee government affairs, engage with policymakers, and lead a high-performing team to support Cochlear's innovative...
Reposted 3 weeks ago
Project Manager, Hydrogen Systems (Pre-Construction & Permitting Focus)
$86K - $135K *
Lead the charge in optimizing pre-construction workflows for hydrogen systems. Collaborate with diverse stakeholders to ensure timely project execution and regulatory compliance, driving efficiency an...
3 weeks ago
Director, Professional Services Group
$120K - $150K *
Join a team that's shaping the future of consulting in P&C insurance. Lead client engagements, ensure quality standards, and foster long-term relationships while driving business growth and mentoring...
3 weeks ago
$114K - $142K *
Drive brand success by leading marketing strategies and campaigns. Collaborate with teams to enhance brand positioning, manage stakeholder relationships, and analyze market trends to achieve organizat...
3 days ago
21GRAMS- Director, Product Design
$140K - $155K *
Empower teams to elevate product design through strategic vision, fostering collaboration across disciplines to create impactful digital experiences that meet user needs and business goals while ensur...
1 week ago
Director of Learning & Development & CX Lead – EMD
$196K - $294K *
Empower the EMD franchise by leading learning strategies and operational execution, driving measurable impact across commercial, medical, and market access teams while fostering a high-performing cult...
Yesterday
Sr Director, Product Management
$160K - $200K *
Drive the evolution of dealer marketing solutions by leading product management efforts, overseeing current offerings, and defining a next-gen platform that enhances customer engagement and retention...
1 week ago
Sr. Technical Project Manager - ECG Management
$105K - $158K *
Unlock potential by managing complex projects in digital healthcare, ensuring product quality and customer satisfaction. Collaborate with cross-functional teams to drive program success and address st...
3 weeks ago
Senior Product Marketing Manager
$120K - $145K *
Champion product marketing strategies in the cybersecurity sector, collaborating across teams to enhance product positioning, messaging, and customer engagement. Drive market presence through compelli...
4 weeks ago
Laboratory Furniture Specialist
$61K - $104K *
Grow your career with a dynamic role focused on promoting lab design and furniture solutions. Engage with customers, manage projects, and drive sales across diverse market segments while collaborating...
Reposted 2 days ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.