Principal Scientist Jobs

Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.

What Does a Principal Scientist Do?

Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.

Skills and Qualifications

Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.

Principal Scientist Salary and Career Outlook

Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.

Find Principal Scientist Jobs on Ladders

Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.

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$120K - $145K *

Unlock potential by leading product marketing strategies for developer-facing solutions. Collaborate across teams to enhance messaging, drive customer engagement, and ensure successful deployments, al...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $115K *

Join a dynamic team as a Senior Project Planner, driving financial health and vendor coordination across multiple brands while ensuring project success through strategic planning and effective communi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Lead the design and implementation of scalable ML systems, bridging business strategy with technical execution. Drive impactful data solutions, mentor teams, and ensure robust model performance to enh...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$186K - $252K *

Shape the future of AI in cybersecurity by designing and delivering advanced LLM and agentic AI systems. Collaborate across teams to establish best practices, mentor engineers, and translate customer...

California, USRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$125K - $150K *

Champion the technical integration of partner ecosystems, ensuring seamless onboarding and operational reliability. Drive API discovery, documentation, and troubleshooting while collaborating with int...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$180K - $240K *

Transform the future of distributed systems by designing and building robust platform components. Collaborate with teams to ensure reliability and scalability in mission-critical environments, driving...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Lead complex Power BI analytics engagements, delivering data-driven solutions that enhance decision-making, foster stakeholder alignment, and support sustained enterprise adoption. Collaborate with cr...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Lead the charge in transforming enterprise security implementations into measurable success. Drive customer outcomes, manage complex programs, and build trusted relationships with executives to ensure...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$107K - $160K *

Lead the charge in enhancing patient safety by providing clinical expertise and oversight across cardiac ablation technologies. Collaborate with cross-functional teams to evaluate safety signals and s...

Minneapolis, MNRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $205K *

Join a dynamic team to lead AI agent deployments in healthcare. Leverage your software engineering expertise and client-facing skills to drive technical delivery, influence product development, and en...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $172K *

Explore a pivotal role in global Payments process excellence, driving standardization, governance, and continuous improvement. Collaborate with diverse teams to enhance payment operations and optimize...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$236K - $295K *

Lead the charge in advancing breakthrough discoveries by guiding a high-performing research team. Set strategic goals, foster collaboration, and translate innovative ideas into transformative medicine...

RemoteRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$222K - $303K *

Champion regulatory excellence by leading CMC strategies for global drug approvals. Collaborate across teams to navigate complex regulations, ensuring compliance and successful product lifecycle manag...

New Jersey, USRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $120K *

Optimize building assessments and capital projects while leading teams and managing client relationships. Oversee project scopes, budgets, and timelines to deliver impactful outcomes in a collaborativ...

Victoria, BCRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Technical Services

$201K - $352K *

Join a team that's redefining enterprise AI by building scalable, LLM-enabled applications. Collaborate with customers to deliver impactful solutions, codify reusable assets, and shape the future of A...

Santa Clara, CARemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$190K - $200K *

Strategize market access initiatives to enhance patient access and reimbursement. Oversee government affairs, engage with policymakers, and lead a high-performing team to support Cochlear's innovative...

Lone Tree, CORemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$86K - $135K *

Lead the charge in optimizing pre-construction workflows for hydrogen systems. Collaborate with diverse stakeholders to ensure timely project execution and regulatory compliance, driving efficiency an...

Johnstown, NYRemote

3 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$120K - $150K *

Join a team that's shaping the future of consulting in P&C insurance. Lead client engagements, ensure quality standards, and foster long-term relationships while driving business growth and mentoring...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$114K - $142K *

Drive brand success by leading marketing strategies and campaigns. Collaborate with teams to enhance brand positioning, manage stakeholder relationships, and analyze market trends to achieve organizat...

Staples, MNRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$140K - $155K *

Empower teams to elevate product design through strategic vision, fostering collaboration across disciplines to create impactful digital experiences that meet user needs and business goals while ensur...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$196K - $294K *

Empower the EMD franchise by leading learning strategies and operational execution, driving measurable impact across commercial, medical, and market access teams while fostering a high-performing cult...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Drive the evolution of dealer marketing solutions by leading product management efforts, overseeing current offerings, and defining a next-gen platform that enhances customer engagement and retention...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$105K - $158K *

Unlock potential by managing complex projects in digital healthcare, ensuring product quality and customer satisfaction. Collaborate with cross-functional teams to drive program success and address st...

Waukesha, WIRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Champion product marketing strategies in the cybersecurity sector, collaborating across teams to enhance product positioning, messaging, and customer engagement. Drive market presence through compelli...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$61K - $104K *

Grow your career with a dynamic role focused on promoting lab design and furniture solutions. Engage with customers, manage projects, and drive sales across diverse market segments while collaborating...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What does a Principal Scientist do?question toggle

    A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.

  • What qualifications are commonly required for Principal Scientist jobs?question toggle

    Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.

  • How much do Principal Scientists earn?question toggle

    Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.

  • Where do Principal Scientists work?question toggle

    Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.

  • How can I find Principal Scientist jobs on Ladders?question toggle

    Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.