Welcome to Principal Scientist Jobs

Grasp unique opportunities in the scientific realm by exploring high-paying Principal Scientist jobs that offer annual remuneration of over $100,000. Broaden your professional horizons and get closer to your career goals with our advanced search tools for Principal Scientists.

Why Principal Scientist Jobs?

As a Principal Scientist, you will lead innovation, drive scientific research, and contribute to the growth of the scientific community at large. It is a role that combines leadership, in-depth scientific knowledge, and impactful decision-making.

Our Offerings

We provide comprehensive job listings, insightful articles, growth opportunities, and a diverse range of resources for Principal Scientists looking to make their next career move.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
More
1
caret down

$150K - $180K *

Drive the technical direction of complex distributed systems, guiding architectural decisions and mentoring teams. Leverage expertise in Go, security, and cloud to tackle high-impact challenges and es...

US-AnywhereRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Pioneer innovative solutions by leading customer discovery and design. Collaborate across teams to deliver impactful architectures that enhance engagement and drive enterprise growth in a high-stakes...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $170K *

Join a team that's redefining aerospace communications by bridging telecommunications and software engineering, ensuring robust integration and performance of advanced communication systems across cus...

US-AnywhereRemote

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $120K *

Champion the adoption of innovative physics products by building relationships, driving sales processes, and translating complex research needs into actionable solutions, enhancing usage and revenue i...

US-AnywhereRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Partner with us to lead the charge in revolutionizing physics research adoption. You'll guide institutions through the full sales lifecycle, ensuring researchers confidently integrate our innovative s...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Unlock potential by analyzing and developing acquisition policies that enhance government operations. Leverage extensive knowledge to evaluate existing frameworks and provide actionable recommendation...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$111K - $151K *

Lead the charge in optimizing procurement strategies, managing a $50M portfolio across HR Services and related categories, while fostering stakeholder relationships globally and driving cost efficienc...

US-AnywhereRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Business Services

$200K - $250K *

Play a key role in shaping AI-driven security operations by leading detection engineering efforts. Collaborate with teams to innovate detection methodologies and improve security solutions for diverse...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $170K *

Accelerate progress at the forefront of energy efficiency programs. Lead strategic initiatives, manage complex operations, and inspire multidisciplinary teams to deliver high-impact results while ensu...

US-AnywhereRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Energy & Utilities

$139K - $153K *

Transform your career by leading complex initiatives in Information Security. Utilize your technical expertise to foster collaboration across teams, manage risks, and ensure successful execution of cr...

US-AnywhereRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$172K - $203K *

Shape the future of scientific research management by leading cross-functional initiatives and strategic partnerships, ensuring alignment between innovative health studies and long-term organizational...

US-AnywhereRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $105K *

Join a dynamic team to develop meteorological tools and enhance decision support services. Collaborate with NOAA scientists and partners to innovate forecast capabilities and improve operational effic...

US-AnywhereRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Join a team that's committed to advancing patient care through innovative biomarker solutions, engaging with stakeholders, and driving scientific dialogue to support clinical practice and research in...

US-AnywhereRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$158K - $199K *

Lead the strategy execution for key global clients, driving client value, retention, and new business growth while cultivating trust-based relationships with senior leaders and maximizing account pote...

US-AnywhereRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $220K *

Contribute to advanced agentic AI systems by designing, building, and deploying production software that optimizes supply chain processes through intelligent automation and rigorous evaluation. Lead p...

US-AnywhereRemote

5 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Pioneer innovative commercial operations by optimizing CRM systems, leading a dynamic team, and enhancing sales strategies to drive measurable performance and revenue growth across Sales, Marketing, a...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $160K *

Lead the charge in redefining enterprise data solutions as a founding solutions engineer. This role combines technical expertise and commercial acumen to architect tailored solutions, drive client eng...

US-AnywhereRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$205K - $295K *

Shape the future of AI Operations by defining and leading platform strategy and governance, ensuring streamlined adoption and utilization of AI capabilities across the enterprise, while collaborating...

US-AnywhereRemote

2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$150K - $178K *

Pioneer a comprehensive Computer System Validation strategy across GxP systems. Collaborate with Quality and IT to drive compliance and data integrity while enhancing efficiency in validation processe...

US-AnywhereRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Elevate your career by leading compliance and quality in clinical trials. Collaborate with teams to ensure protocol adherence, site training, and resolve issues while maintaining high standards of mon...

US-AnywhereRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $130K *

Tackle clinical monitoring challenges while leading site initiatives for quality compliance and protocol adherence. Collaborate with cross-functional teams to ensure successful clinical trial executio...

US-AnywhereRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $115K *

Optimize your clinical research career by playing a vital role in overseeing and conducting site monitoring for clinical trials, ensuring compliance, quality, and effective team collaboration througho...

US-AnywhereRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock potential by leading site monitoring for clinical trials. Collaborate closely with cross-functional teams to ensure compliance, enhance recruitment, and oversee execution while providing guidan...

US-AnywhereRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Innovate global CMC regulatory strategies and submissions for biological products. Ensure high-quality compliance with US and Canadian regulations, while collaborating cross-functionally to manage lif...

US-AnywhereRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $170K *

Drive supply chain innovation and technical excellence across health programs, guiding procurement, logistics, and commodity security strategies to enhance public health outcomes globally...

US-AnywhereRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What is the role of a Principal Scientist?question toggle

    A Principal Scientist typically leads scientific research, explores innovative ideas, and guides a team of scientists towards achieving the organization's scientific goals.

  • How much does a Principal Scientist earn on average?question toggle

    The average salary of a Principal Scientist varies depending on the industry and level of experience. However, on Ladders, you can find Principal Scientists jobs that pay over $100,000.

  • What qualifications are required for Principal Scientist jobs?question toggle

    Most Principal Scientist roles require at least a Ph.D. in a relevant scientific field along with several years of research experience. Leadership skills and a proven research track record are typically also essential.

  • Can I find remote Principal Scientist jobs on Ladders?question toggle

    Yes, on Ladders, you can find both remote and in-office high-paying Principal Scientist jobs.