Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Senior/Staff Attack Engineer, Rapid Response
$230K - $275K *
Lead the charge in vulnerability research and exploitation techniques, transforming real-world threats into automated solutions. Collaborate with teams to enhance security measures and validate defens...
4 weeks ago
Associate Medical Director, Renal Cancer Theranostics
$175K - $210K *
Champion the execution of a comprehensive medical affairs plan for renal cancer theranostics, driving cross-functional alignment and strategic initiatives to enhance patient outcomes and advance clini...
3 weeks ago
Project Manager- Professional Services
$110K - $130K *
Lead end-to-end client engagements for complex AI and digital projects, managing multiple implementations while ensuring timely delivery and exceeding client expectations. Collaborate with cross-funct...
Reposted 2 days ago
Director/Client Partner - Enterprise AI
$180K - $220K *
Transform enterprise AI partnerships by leading strategic growth initiatives, enhancing relationships, and driving revenue across key Google organizations. Leverage your expertise in AI, cloud, and di...
Reposted 2 days ago
Senior Director, Account Management
$140K - $175K *
Accelerate progress at our company by driving growth within existing accounts. Leverage strategic relationships and insights to enhance customer success and maximize product adoption, ensuring long-te...
Yesterday
$110K - $130K *
Lead the end-to-end delivery of enterprise SaaS implementations, managing budgets, timelines, and stakeholder relationships to ensure successful project outcomes and high client satisfaction...
4 weeks ago
Sr. Process Engineer - Semi Conductor
$88K - $154K *
Advance your career by leading process engineering for semiconductor projects. Collaborate with cross-functional teams to optimize systems, ensuring compliance with industry standards while mentoring...
3 days ago
Senior Clinical Trial Manager - Oncology
$112K - $222K *
Empower the clinical site management team from initiation to closure, ensuring effective monitoring and sponsor engagement. Drive results while fostering a collaborative and professional environment...
Reposted 2 weeks ago
$90K *
Contribute to high-impact proposal development by crafting persuasive narratives that align with client needs and competitive positioning, ensuring compliance and strategic messaging throughout the pr...
2 weeks ago
Manager, Talent Operations & Enablement
$95K - $115K *
Unlock operational excellence by leading talent acquisition processes and programs. Drive team development, enhance recruiting efficiency, and partner with stakeholders to strengthen talent pipelines...
3 days ago
Director, Technical Product Management
$150K - $180K *
Pioneer the strategy and execution of data platforms and AI products, leading cross-functional teams to enhance commercial life sciences solutions while driving revenue growth and product adoption in...
Reposted 1 week ago
$120K *
Lead the charge in tropical cyclone research, utilizing advanced satellite data to enhance forecasting and decision support systems. Collaborate with experts to develop innovative methodologies and se...
3 weeks ago
Lifecycle Solutions Sales Manager U.S.
$110K - $130K *
Join a team that's shaping the future of aftermarket solutions by driving growth through strategic customer engagement and innovative lifecycle management. Collaborate cross-functionally to enhance pr...
1 week ago
Director, Drug Safety Physician
$280K - $311K *
Optimize safety evaluations within our Drug Safety team to drive innovative strategies for monitoring and managing clinical risks, ensuring compliance and maintaining high-quality standards in pharmac...
Reposted 2 days ago
Senior Principal Consultant - HCM Change Management & Training
$95K - $210K *
Optimize organizational change management strategies to enhance stakeholder engagement and training for enterprise IT implementations. Lead teams, develop training curricula, and ensure effective comm...
Today
Program Manager, NGDCA Program Office
$120K - $145K *
Drive the growth of the NGDCA Program Office, managing a team and overseeing multi-year engineering initiatives while ensuring effective collaboration across functions and maintaining rigorous decisio...
Today
Associate Director/Director Project Management
$135K - $160K *
Champion cross-functional project management for drug development, ensuring effective planning, execution, and governance across complex initiatives. Collaborate with diverse teams to drive Phase 3 re...
2 weeks ago
Biostatistical Programming Sr Mgr
$151K - $205K *
Engineer innovative biostatistical programming solutions, leading cross-functional teams to ensure timely delivery of clinical data analysis and compliance. Drive operational excellence in biosimilar...
Today
$150K - $180K *
Unlock potential by leading client teams to drive retention and growth. Collaborate cross-functionally to shape strategic market positioning and nurture executive relationships, all while cultivating...
Reposted 1 week ago
Consultant, Product Safety and Stewardship
$68K - $94K *
Transform the landscape of environmental health by joining our team as a Consultant. Collaborate on impactful projects addressing chemical safety and risk assessment, while developing your skills in a...
Today
$148K - $263K *
Champion innovative financial solutions by leading complex OneStream implementations. Collaborate with teams to design scalable architectures, optimize performance, and ensure high-quality deliverable...
2 days ago
$148K - $263K *
Architect high-performance OneStream solutions by translating complex requirements into scalable designs. Lead a team of consultants, ensuring technical quality and optimizing integrations while excee...
1 week ago
$80K - $100K *
Join a team that's driving financial insights and pricing strategies to enhance profitability. Collaborate with cross-functional teams to support client proposals and contract renewals while navigatin...
Reposted 5 days ago
Account Director, Business Development (Central Labs) US - Boston
$95K - $158K *
Join a team that's dedicated to driving client acquisition and retention in the small and mid-sized pharmaceutical market. Manage relationships, develop strategies, and achieve sales targets while col...
3 weeks ago
Quality & Regulatory Technology & Innovation - Remote
$130K *
Partner with us to innovate and transform Quality & Regulatory operations through technology and data analytics. Drive automation, improve efficiency, and foster effective digital solutions that enhan...
Reposted 3 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.