Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
$110K - $130K *
Drive efficient order management and logistics operations, ensuring compliance with pharmaceutical regulations while collaborating with internal teams and 3PL partners to optimize product flow and per...
Reposted today
Product Manager, National Center for Clinical Trials (NCCT)
$122K - $183K *
Transform how we operate by leading technology-driven initiatives that enhance business capabilities. Collaborate with cross-functional teams to define product strategies and drive measurable outcomes...
6 days ago
$110K - $130K *
Empower decision-making by utilizing data-driven insights to enhance operations, supporting growth through statistical modeling and AI techniques while maintaining compliance in a complex regulatory e...
Reposted 2 weeks ago
Senior Manager, Clinical Operations
$136K - $171K *
Pioneer clinical trial excellence by leading operational planning and execution. Collaborate cross-functionally to ensure compliance, quality, and timely delivery of clinical studies while mentoring j...
2 weeks ago
Senior Director, Drug Safety and Pharmacovigilance Operations
$295K - $312K *
Join a team that's shaping the future of drug safety! Provide operational leadership across pharmacovigilance functions, oversee compliance and vendor relationships, and ensure high-quality safety rep...
Reposted 2 days ago
Enterprise Software Account Manager
$100K - $110K *
Empower corporate veterinary groups by driving software adoption and growth. Collaborate with cross-functional teams to develop strategic partnerships, influence decisions, and enhance customer satisf...
1 week ago
Principal Product Manager, Agentic AI Platform
$185K - $312K *
Transform the Agentic Platform as a Principal PM, leading AI agent development across teams. Shape technical direction, enhance developer experience, and ensure seamless integration for impactful cust...
3 days ago
Senior Program Manager, Leader Enablement & Development
$110K - $130K *
Transform frontline manager development by leading strategic programs that enhance coaching, deal inspection, and pipeline management. Collaborate cross-functionally to drive consistent team performan...
4 weeks ago
Senior Pharmacovigilance Associate
$80K - $115K *
Explore a pivotal role in pharmacovigilance, ensuring regulatory compliance and safety management for cancer therapies. Collaborate with cross-functional teams to enhance drug safety processes and sup...
3 weeks ago
Senior Manager, GRC Engineering
$120K - $145K *
Lead compliance initiatives by managing cybersecurity projects and teams. Collaborate with clients to ensure excellence in service delivery while steering resource strategy and risk mitigation to meet...
Reposted today
Director - AI Digital Product Management - Commercial Value & Access
$199K - $269K *
Grow your career with a leadership role in AI Digital Product Management, driving strategy and innovation across a portfolio of AI products. Collaborate with cross-functional teams to deliver scalable...
4 weeks ago
$103K - $176K *
Transform downstream marketing for cutting-edge medical devices. Drive product launches, develop compelling content, analyze market trends, and ensure regulatory compliance across global regions while...
Reposted 1 week ago
Senior Enterprise Business Process Architect
$130K - $160K *
Lead the transformation of enterprise business processes to enhance efficiency and effectiveness. Collaborate with stakeholders to architect solutions that drive operational excellence across the orga...
Reposted 3 weeks ago
Senior Director, Business Development
$194K - $266K *
Lead the charge in driving commercial growth by securing high-value partnerships and expanding market presence. Mentor a dynamic team while executing strategic initiatives that enhance client relation...
2 weeks ago
$74K - $96K *
Transform cultural resource management by leading diverse projects, ensuring compliance and quality while fostering collaboration. Engage with clients and stakeholders to deliver successful outcomes i...
2 days ago
Epic Solutions Architect (Laboratory)
$110K - $130K *
Architect innovative laboratory solutions by designing, developing, and deploying clinical applications. Collaborate with stakeholders to enhance workflows and ensure seamless integration, driving ope...
Reposted 1 week ago
$110K - $160K *
Transform advanced semiconductor facilities by leading electrical design projects. Collaborate with multi-discipline teams to ensure compliance, quality, and innovation while utilizing cutting-edge AI...
1 week ago
$110K - $160K *
Transform the future of technology by leading electrical design for advanced semiconductor facilities. Collaborate with multidisciplinary teams to ensure compliance, innovation, and quality in every p...
1 week ago
$80K - $95K *
Drive environmental solutions by applying scientific principles to analyze data, prepare reports, and ensure compliance with regulations. Collaborate with project teams to execute fieldwork and suppor...
1 week ago
Principal Engineer, Unity Rewards
$179K - $341K *
Architect and lead the mobile app development for a consumer rewards platform. Create engaging UI/UX, integrate backend systems, and manage virtual economies while mentoring engineering talent and ens...
Reposted 1 week ago
$131K - $205K *
Shape the future of electric power projects by providing expert development support, technical evaluations, and engineering design reviews. Collaborate with clients to optimize project outcomes while...
3 weeks ago
Senior Technical Account Manager
$110K - $130K *
Join a team that's dedicated to enhancing customer success through expert guidance in Privilege Access Management. Leverage your technical skills to support enterprise clients, ensuring seamless deplo...
1 month ago
Senior Security Engineering Manager
$150K - $180K *
Shape the future of security engineering by leading a high-performing team, enhancing operational excellence, and translating security risks into actionable priorities in a dynamic, growth-focused env...
2 days ago
Senior Manager, Technical Support Engineering
$147K - $205K *
Innovate with us to lead global Technical Support Engineering operations, enhancing customer experience through effective problem-solving, operational excellence, and team development. Drive continuou...
Reposted yesterday
Senior/Staff Attack Engineer, Rapid Response
$230K - $275K *
Lead the charge in vulnerability research and exploitation techniques, transforming real-world threats into automated solutions. Collaborate with teams to enhance security measures and validate defens...
4 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.