Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
$171K - $269K *
Collaborate with cross-functional teams to analyze data, develop strategies, and influence product roadmaps. Use technical expertise to solve business challenges and communicate insights effectively t...
3 weeks ago
$150K - $180K *
Lead and grow a high-performing Guidewire practice, driving strategy and delivery excellence in digital transformations for insurance clients, while fostering client relationships and mentoring teams...
Reposted 5 days ago
$120K - $150K *
Champion data innovation by leading a skilled engineering team to enhance our enterprise data platform. Drive architectural excellence and streamline processes across Azure and Microsoft Fabric, ensur...
1 week ago
$125K - $150K *
Unlock potential by leading global sourcing operations, optimizing procurement strategies, and driving cost savings while enhancing supplier relationships and ensuring transparency in spending across...
Today
$138K - $165K *
Elevate our product management efforts by driving innovation in cybersecurity. Collaborate with cross-functional teams to deliver impactful data-driven analytics, leveraging user insights and industry...
Reposted 2 weeks ago
$180K - $190K *
Empower our team to drive innovation by developing crucial AI tools that enhance operational efficiency. Oversee governance, training, and metrics to ensure impactful adoption across departments while...
Reposted 1 week ago
Product Manager, Property Intelligence
$95K - $158K *
Transform the Property Intelligence platform by connecting customer needs with product insights. Collaborate across teams to enhance product adoption and engagement through analytics and feedback, dri...
1 week ago
Director, Global HR Operations
$175K - $195K *
Shape the future of global HR operations by enhancing systems and processes for a seamless employee lifecycle. Collaborate cross-functionally to improve workflows, compliance, and service effectivenes...
Reposted 4 days ago
Senior Director, Client Sales & Insights
$100K - $130K *
Drive commercial activation and revenue growth for a multi-million-dollar portfolio, leveraging strategic insights and AI to enhance client engagement and decision-making. Lead cross-functional teams...
1 week ago
$163K - $217K *
Lead the charge in establishing global technical standards for utility and power systems. As a strategic authority, you'll guide complex engineering decisions and mentor teams across diverse projects...
1 week ago
Staff Engineer, Detection and Response
$225K - $281K *
Lead the charge in shaping detection and response strategies, driving hands-on initiatives to enhance security architecture and incident management. Collaborate across teams to ensure robust threat de...
2 weeks ago
Senior Engineering Manager, Co-Intelligent Coaching
$202K - $253K *
Drive the development of AI-driven coaching solutions, overseeing multiple squads from prototype to production. Ensure quality delivery, manage resources effectively, and foster team growth while main...
3 days ago
$160K - $170K *
Elevate data engineering excellence by designing and implementing complex data solutions, mentoring engineers, and collaborating across teams to drive impactful data initiatives and architectural inno...
Reposted 1 week ago
Lead Specialist, Technical Architect
$150K - $160K *
Partner with us to shape the quality strategy for a leading exam development platform. Leverage your expertise to guide multiple Agile teams, enhance automation practices, and ensure high standards ac...
Reposted 2 days ago
$108K - $130K *
Shape the future of Precision Guided Munitions by leading capture strategies, managing cross-functional teams, and ensuring compliance with program objectives. Drive innovation and enhance program per...
2 weeks ago
Senior Field Engineer, Data Center Design and Engineering
$320K - $405K *
Transform the future of data center engineering by resolving on-site technical issues, collaborating with contractors, and ensuring project success through effective problem-solving and communication...
1 week ago
Senior Manager, Narrative Intelligence
$173K - $255K *
Champion data-driven insights to shape brand narratives and audience understanding. Lead research and analytics to connect diverse data sources, measure narrative performance, and inform strategic com...
Today
Senior Manager, Narrative Intelligence
$153K - $213K *
Lead the charge in transforming data into actionable insights that shape brand narratives. Drive audience understanding and narrative performance measurement to enhance strategic decision-making acros...
Today
$100K - $195K *
Take ownership of designing automated systems and robotic equipment for remote operations in radiological environments. Collaborate with cross-functional teams to ensure effective integration and perf...
3 weeks ago
Principal Customer Success Manager, Aerospace, Propulsion & Energy
$177K - $224K *
Lead strategic customer relationships in aerospace and energy sectors, driving renewals and engineering engagements. Own key accounts, transition pricing models, and ensure customer success through te...
1 week ago
Corporate Development Professional-Boston Region
$150K - $185K *
Drive innovation by scouting and assessing external technologies to enhance portfolio growth. Collaborate with diverse teams and engage with industry networks to identify strategic opportunities and s...
3 days ago
Executive Director, Global FP&A and Business Partnering
$170K - $338K *
Drive enterprise-wide financial strategy and performance by leading a global FP&A team. Collaborate with executive leadership to influence critical decisions, enhance financial capabilities, and suppo...
1 week ago
Clinical Team Manager / Sr. (CTM) - HemOnc
$110K - $130K *
Drive the management of clinical trials to meet deliverables within contractual timelines while ensuring compliance with industry standards and project expectations. Collaborate with cross-functional...
Reposted 2 days ago
Senior Research Analyst - Temporary Worker
$114K - $120K *
Transform data into actionable insights by conducting advanced analysis and developing compelling reports. Collaborate with cross-functional teams to support leading B2B brands and enhance research qu...
2 weeks ago
Plant Process Simulation Engineer II
$115K - $150K *
Join a team that's dedicated to advancing clean energy by developing and owning plant process simulation models. Collaborate across disciplines to enhance design, operations, and plant dynamics for in...
1 week ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.