Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Sr. Data Scientist, Forward-Deployed
$168K - $230K *
Lead impactful data science initiatives by measuring engagement outcomes and building customer models. Collaborate with senior data scientists to drive analytics that directly influence business succe...
Reposted 2 days ago
Senior Director, National Field Excellence
$217K - $271K *
Launch your career by owning the national Field Excellence model, managing operations for a groundbreaking oncology therapy. Collaborate with sales leaders to enhance prescriber access and streamline...
2 weeks ago
Senior Advisor Manufacturing Package Design
$144K - $250K *
Join a team that's driving packaging innovation in drug product manufacturing. Lead technical strategy and design for late-stage clinical programs, ensuring quality and compliance while collaborating...
Reposted today
$160K - $190K *
Empower nonprofit organizations to maximize their impact by leading product strategy and execution for innovative fundraising solutions. Drive growth through deep customer insights, collaborative part...
Reposted 3 weeks ago
Account Manager, Minerals and Nutrients
$130K - $150K *
Accelerate growth by managing sales strategies across CA and parts of the Midwest. Lead market development efforts, achieve sales goals, and collaborate with cross-functional teams to enhance customer...
2 weeks ago
$91K - $137K *
Accelerate progress at the forefront of global site start-up activities, managing strategies and coordinating efforts to ensure timely activation. Collaborate with stakeholders and mentor teams to dri...
3 days ago
$203K - $366K *
Innovate and lead a high-performing software development team to deliver scalable enterprise Time and Pay solutions. Collaborate with HR and Finance to drive strategy and enhance operational efficienc...
2 weeks ago
Principal Product Manager- Risk and Compliance
$106K - $181K *
Join our team to lead risk and compliance strategies across payment products. Drive cross-functional collaboration, manage product lifecycles, and ensure compliance while leveraging AI tools to enhanc...
1 week ago
Grants Consultant - Scientific Research Focus
$82K - $110K *
Elevate your career by partnering with us to support higher education clients in crafting competitive grant proposals. Leverage your expertise in scientific research and grantsmanship to drive impactf...
Yesterday
$140K - $170K *
Lead the charge in pioneering marketing analytics by managing client engagements, guiding a skilled team, and driving growth through strategic insights and innovative methodologies in data science...
Reposted 1 week ago
Associate Director, Registry Operations Management
$120K - $145K *
Lead operational excellence in clinical registry programs, ensuring compliance and performance across cross-functional teams. Drive strategic initiatives, manage risks, and enhance site engagement whi...
Reposted today
$164K - $201K *
Innovate with us as you lead technical engagements, build partnerships, and shape AI datacenter trends. Collaborate with top talent to drive impactful solutions and support product development in a dy...
4 weeks ago
Environmental Scientist - Technical Reporting & Remediation
$73K - $132K *
Contribute to impactful environmental projects by analyzing data, preparing technical documents, and collaborating with multidisciplinary teams to support CERCLA investigations and remediation efforts...
Reposted 3 weeks ago
Principal Product Quality Leader
$138K - $187K *
Lead cross-functional quality initiatives to enhance product health and compliance. Collaborate with diverse teams on regulatory submissions, quality assessments, and process improvements for late-sta...
1 week ago
Senior Director, Clinical Safety Physician
$310K - $350K *
Lead the charge in medical safety oversight for clinical-stage investigational products, ensuring robust evaluation and communication of safety data. Collaborate with cross-functional teams to integra...
Today
Senior Director of Account Management
$150K - $180K *
Lead a dynamic account management team, driving strategic relationships with major health systems. Foster high-touch engagement, ensuring customer success and operational excellence while directly man...
3 weeks ago
$175K - $210K *
Architect transformative R&D initiatives that leverage AI and ML, ensuring platform stability and excellence. Join dynamic teams to drive innovation and quality in clinical technology solutions at a g...
Reposted 3 days ago
$160K - $180K *
Drive innovation as a Senior Product Manager, leading strategic initiatives in Adaptive Training and Continuous Learning. Collaborate with cross-functional teams to enhance user experiences and achiev...
1 week ago
Senior Manager, Real World Evidence
$151K - $226K *
Lead the charge in managing observational research projects, ensuring operational excellence and cross-functional collaboration. Drive timely delivery of high-quality Real-World Evidence to support cl...
3 days ago
Senior Director, HPC Deployment at Scale
$175K - $210K *
Unlock potential by leading high-volume GPU and HPC cluster deployments. Drive execution at scale, ensuring quality and timely delivery across multiple sites while building a robust operational framew...
2 days ago
Manager, Commercial Accounting
$134K - $145K *
Optimize commercial accounting processes by managing revenue, inventory, and accounts receivable. Collaborate with cross-functional teams to ensure accurate financial reporting and drive process impro...
Reposted 2 days ago
Vice President of Data Engineering - Hospital Systems
$297K - $367K *
Grow your career with a pivotal role driving hospital data integration and compliance. Lead execution of clinical data operations, build relationships, and ensure secure data handling while shaping a...
Reposted 2 days ago
$171K - $269K *
Collaborate with cross-functional teams to analyze data, develop strategies, and influence product roadmaps. Use technical expertise to solve business challenges and communicate insights effectively t...
3 weeks ago
$150K - $180K *
Lead and grow a high-performing Guidewire practice, driving strategy and delivery excellence in digital transformations for insurance clients, while fostering client relationships and mentoring teams...
Reposted 5 days ago
$120K - $150K *
Champion data innovation by leading a skilled engineering team to enhance our enterprise data platform. Drive architectural excellence and streamline processes across Azure and Microsoft Fabric, ensur...
1 week ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.