Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Sr. Director, eDiscovery Technology & AI
$156K - $195K *
Champion the global eDiscovery Technology practice, leading a diverse team to innovate AI-assisted workflows, ensuring defensibility and quality across jurisdictions while driving growth and operation...
2 weeks ago
$110K - $130K *
Transform marketing strategies by leading global initiatives that drive commercial growth and enhance technical communication for innovative technology in the mining industry. Collaborate cross-functi...
3 days ago
Principal Engineer, DNA Platforms
$186K - $285K *
Elevate your impact by defining the technical vision and architecture for critical platforms. Collaborate with cross-functional teams to solve complex challenges while leading modernization and engine...
Reposted 1 week ago
Staff Product Manager, Agentic Test Intelligence
$168K - $285K *
Lead the development of Test & Code Coverage capabilities, transforming complex challenges into actionable strategies. Collaborate with cross-functional teams to enhance software quality and streamlin...
3 weeks ago
$135K - $160K *
Tackle complex optimization challenges by developing scalable decision systems in supply chain operations. Collaborate with cross-functional teams to enhance analytical models, ensuring alignment with...
1 week ago
Sr. Dir. Regulatory Affairs, Head of Global Labeling and Labeling Operations
$268K - $368K *
Unlock potential by leading global labeling strategy and operations, ensuring compliance and alignment across product lifecycles. Collaborate with cross-functional teams to drive effective labeling ne...
2 days ago
$120K - $145K *
Contribute to innovative cloud solutions by leveraging your expertise in Azure, C#/.NET, and DevOps practices. Collaborate with cross-functional teams to enhance security, scalability, and performance...
3 weeks ago
$110K - $130K *
Transform customer IT service requirements into innovative solutions that enhance loyalty and profitability. Lead technical resources in delivering high-quality financial industry solutions while ensu...
4 weeks ago
Principal Architect, Sales and Marketing Technologies
$170K - $180K *
Join us as a Technology Architect to shape and govern our Sales & Marketing tech ecosystem. Lead architecture design, drive integration strategies, and mentor teams to enhance client engagement and op...
Today
Principal Consultant - Senior SAP Account Manager
$150K - $180K *
Grow enterprise SAP relationships by managing key accounts and driving new business. Leverage your expertise to expand client portfolios, develop strategic plans, and ensure client satisfaction while...
1 week ago
Mechanical and Design Engineer
$93K - $137K *
Innovate across capital projects and chemical operations, delivering practical mechanical engineering solutions while collaborating with multidisciplinary teams to ensure effective project execution a...
Reposted 2 days ago
$145K - $175K *
Join a team that's redefining AI-driven solutions by leading product development for an innovative tech concierge. Drive the evolution of agent capabilities, ensuring quality and reliability while col...
2 weeks ago
$150K - $180K *
Optimize engagement and monetization strategies for an AI-driven product, transforming customer interactions into measurable growth. Lead cross-functional teams to innovate and implement effective use...
2 weeks ago
Senior Forward Deployed AI Architect (GenAI, AWS)
$180K - $200K *
Lead transformative AI projects by embedding within client teams, delivering production-ready solutions that drive real business impact. Collaborate closely with stakeholders to understand needs and s...
6 days ago
Director, Advanced Analytics and Data Science - Innovation
$174K - $234K *
Shape the future of advanced analytics and AI, driving data-driven solutions across commercial, medical, and clinical operations. Collaborate cross-functionally to deliver insights, enhance decision-m...
Reposted 4 weeks ago
Manager, Industry Partnerships
$100K - $120K *
Champion strategic partnerships to drive pipeline growth, manage relationships with industry executives, and enhance collaboration with sales teams. Shape a dynamic partner program that translates con...
Today
Senior Director, Oncology Pharmacology
$232K - $348K *
Lead the charge in oncology pharmacology, managing scientific teams to drive drug discovery from early stages through regulatory approval while ensuring alignment across cross-functional teams...
Reposted 2 weeks ago
$90K - $140K *
Drive project success in clinical research by managing cross-functional teams, ensuring timely deliverables, and maintaining regulatory compliance. Leverage your expertise to enhance operational effic...
1 week ago
$135K - $160K *
Lead the development of a comprehensive data strategy, focusing on modern architecture and tools. Drive real-time insights and decision-making while managing a high-performing team to enhance the orga...
Reposted 1 week ago
Director / VP, Government Relations
$143K - $225K *
Shape the future of federal policy by leading congressional engagement and driving funding strategies. Collaborate with executive leadership to translate technical capabilities into actionable priorit...
Today
$109K - $151K *
Pioneer strategies in Amazon marketplace for diverse beauty brands, driving growth and optimizing performance. Lead and develop teams while managing P&L, fostering collaboration, and enhancing brand v...
Reposted 1 week ago
$94K - $129K *
Unlock the potential of IT security across the Americas, managing systems and protocols to enhance regional safety. Your expertise will drive compliance and strategic initiatives, fostering a robust s...
Reposted 1 week ago
Project Manager, Delivery Lead
$95K - $115K *
Elevate project delivery by leading cross-functional teams in Interactive Response Technology, ensuring client satisfaction and timely execution while managing risks and fostering continuous improveme...
1 month ago
$110K - $130K *
Lead the development of accurate proposals and cost estimates for water and wastewater projects. Collaborate with engineering, sales, and finance teams to ensure timely delivery and customer satisfact...
2 days ago
Clinical Lead - Site Activation Lead
$116K *
Lead site activation efforts by coordinating with cross-functional teams to ensure timely and quality delivery of clinical projects. Drive strategic initiatives and mitigate risks while enhancing comm...
2 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.