Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Director of Technology & Product
$115K - $135K *
Innovate technology strategy and operations, leading a team to enhance product lifecycle and client solutions. Collaborate with executives to implement AI tools and ensure effective vendor management...
1 week ago
Lead Bioinformatics Scientist (Oncology)
$130K - $163K *
Champion the analytical validation of NGS assays, driving real-world evidence studies and collaborating with cross-functional teams to enhance oncology applications and support regulatory submissions...
1 week ago
Enterprise Market Development Manager
$94K - $142K *
Champion enterprise growth by identifying and advancing strategic opportunities across healthcare networks. Build relationships with key stakeholders to develop impactful business cases and partnershi...
2 weeks ago
Senior Vice President, Consumer Panel & Behavior Products| Level 22| US: Remote
$325K - $343K *
Lead the charge in shaping the product vision and strategy for consumer panel and behavioral measurement solutions, driving growth through innovative AI-native practices and client collaboration...
1 week ago
$128K - $185K *
Unlock potential by driving strategic initiatives through data analysis, market research, and project support. Collaborate across teams to enhance growth opportunities while managing the diligence pro...
Reposted yesterday
$95K - $110K *
Discover user needs and drive product decisions as a UX Researcher, collaborating with cross-functional teams to conduct research, usability studies, and synthesize insights that enhance user experien...
1 week ago
Associate Director, Project Management, Patient Support Program Operations
$177K - $221K *
Optimize patient access by leading cross-functional initiatives, managing operational priorities, and driving accountability for results in a dynamic healthcare environment. Collaborate with stakehold...
2 days ago
Sr Director - Program Management
$172K - $258K *
Shape the future of enterprise technology by leading complex, cross-functional programs. Drive ERP transformations, SaaS implementations, and infrastructure projects while ensuring governance and deli...
Yesterday
Regulatory Compliance Engineer II
$85K - $125K *
Shape compliance strategies across hardware and biotech sectors, ensuring products meet global regulatory standards and collaborating with cross-functional teams to drive innovative solutions and main...
Reposted 1 week ago
$105K - $120K *
Empower healthcare professionals by engaging remotely with cardiologists, nephrologists, and primary care providers. Drive sales and support efforts in open territories while delivering a consistent e...
Reposted 2 days ago
Product Manager (Single Cell Sequencing Tech)
$135K - $195K *
Unlock your potential as you drive product success in the genomics field. Collaborate across teams to advocate for customers, define market needs, and launch innovative products that shape the future...
3 weeks ago
BioPharma Production Specialist
$86K - $146K *
Champion customer success by managing key accounts, driving growth, and enhancing satisfaction through strategic engagement and consultative support. Leverage your expertise to mentor peers and execut...
2 weeks ago
$93K - $120K *
Transform business intelligence into actionable insights by leading product strategy and development. Collaborate across teams to create scalable solutions that enhance decision-making and drive measu...
Reposted 3 days ago
Senior Director, Business Development
$150K - $180K *
Join a team that's driving growth in the biopharmaceutical sector by developing strategic business relationships, prospecting new clients, and leading sales initiatives to achieve organizational objec...
1 week ago
Quality Control, Validation Lead
$110K - $130K *
Join a team that's shaping the future of Quality Control laboratories by providing technical oversight for startup, validation, and compliance across multiple manufacturing sites, ensuring operational...
3 weeks ago
Director, Sales – Global Strategic Accounts
$150K - $180K *
Empower a high-performing sales team to drive strategic growth and customer engagement in the biopharma sector. Lead complex sales initiatives, build executive relationships, and translate business st...
1 week ago
Senior Product Manager, Applied AI
$153K - $213K *
Drive efficiency by automating internal processes, enhancing productivity across teams. Collaborate with stakeholders to identify bottlenecks, implement AI solutions, and ensure measurable impact on w...
4 weeks ago
Senior Director, Research Technology
$134K - $224K *
Shape the future of clinical research technology by leading cross-functional teams to develop innovative solutions that enhance user experience and drive operational excellence in global clinical tria...
Today
$150K - $180K *
Lead Corporate FP&A initiatives, driving budgeting, forecasting, and performance management. Oversee financial analysis and reporting while enhancing systems and dashboards for improved decision-makin...
3 weeks ago
Director of Product Management, Data Science
$150K - $180K *
Pioneer a data-driven future by leading product strategy for data science solutions. Drive innovation, oversee development, and ensure alignment with business goals to deliver impactful analytics prod...
4 weeks ago
Senior Identity Governance Engineer
$134K - $201K *
Design and engineer identity governance solutions to ensure secure access across diverse environments. Collaborate with cross-functional teams to implement standards, automate workflows, and maintain...
1 week ago
Lead Specialist, Learning Scientist (Clinical)
$95K - $115K *
Champion innovative research in clinical assessments, leading product development and strategy across multiple domains. Collaborate with cross-functional teams to translate scientific evidence into im...
Yesterday
$105K - $150K *
Transform healthcare insights by leading client engagements with real-world data. Drive business development and project delivery while building long-term client relationships in a dynamic, hybrid wor...
Reposted 2 weeks ago
$109K - $164K *
Drive advanced digital forensics and incident response initiatives while mentoring a skilled engineering team. Leverage deep technical knowledge to enhance operational capabilities and ensure exceptio...
Reposted 3 weeks ago
$120K - $150K *
Transform your career by leading a dynamic team to ensure clinical excellence across multiple regions, driving project success through strategic management and collaboration while fostering a culture...
Reposted 2 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.