Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Bioanalytical Technical Proposal Manager
$100K - $120K *
Shape the future of technical proposals by collaborating with cross-functional teams to create compelling, scientifically accurate documents that meet client needs and drive business success in the li...
2 weeks ago
Senior Director, Global People Operations
$232K - $290K *
Shape the future of global People Operations by leading innovative HR service delivery, enhancing employee experiences, and driving operational excellence in a rapidly scaling biopharmaceutical enviro...
4 weeks ago
$150K - $180K *
Optimize quality operations for large-scale data pipelines, ensuring high standards and consistency across diverse datasets. Lead a team to enhance efficiency and reliability in audio data processing...
4 weeks ago
$110K - $130K *
Lead the charge in delivering high-impact consulting solutions for clients in the Energy & Utilities sector. Manage engagements, build relationships, and mentor teams to drive client success and strat...
1 week ago
Senior Manager, In-Vitro Diagnostics/Precision Medicine Quality
$132K - $178K *
Champion quality in In-Vitro Diagnostics and Companion Diagnostics. Lead proactive strategies, ensuring compliance in clinical trials while collaborating with partners to enhance precision medicine in...
4 weeks ago
$120K - $145K *
Transform healthcare data solutions by designing scalable architectures, optimizing data pipelines, and ensuring compliance with regulations. Collaborate with cross-functional teams to deliver high-qu...
Reposted 1 week ago
Senior Applied Scientist II, Ads Optimization
$240K - $253K *
Pioneer innovation in real-time bid optimization systems, driving advertising performance by turning complex mathematical insights into robust production code. Lead cross-functional initiatives to max...
Reposted 6 days ago
$91K - $148K *
Transform your career by leading complex projects, managing resources, and ensuring quality deliverables. Collaborate with diverse teams to drive strategic initiatives and maintain client relationship...
2 weeks ago
Senior Director, Global Field Operations
$175K - $210K *
Lead global field operations, driving strategy and execution across sales, technical services, and partner functions. Collaborate with senior leadership to optimize pipeline management, forecasting, a...
3 weeks ago
Advanced Specialist, Product Management
$100K - $140K *
Champion product strategy and innovation, driving enhancements through AI and user insights. Collaborate with teams to deliver measurable outcomes and improve workflows in high-stakes assessment envir...
Reposted today
Principal Polymer Processing Engineer, Injection Molding
$138K - $176K *
Drive innovation in polymer processing by leading injection molding initiatives, optimizing manufacturing performance, and collaborating across teams to enhance product quality and efficiency in medic...
1 week ago
$116K - $182K *
Lead the charge in clinical study management, overseeing strategy and execution for complex trials. Collaborate with cross-functional teams to ensure compliance, budget adherence, and timely delivery...
1 week ago
$139K - $222K *
Join a team that's shaping the future of housing market forecasting. Collaborate with experts to develop innovative models, extract key features, and communicate insights that drive strategic decision...
4 weeks ago
Director, Portfolio Management & Project Delivery
$135K - $160K *
Shape the future of technology project delivery by leading a high-performing team, managing strategic initiatives, and ensuring alignment with business objectives to maximize value and drive organizat...
3 weeks ago
Associate Director, Web Experience Delivery
$179K - $246K *
Drive your career forward by leading a dynamic team that crafts and delivers exceptional digital experiences. Oversee web content, UX design, and front-end development while ensuring quality and opera...
2 weeks ago
Senior Systems Analyst - HR Technology Services (HRTS)
$110K - $130K *
Lead the charge in complex HR technology initiatives, coordinating Workday enhancements and integrations. Utilize your analytical skills to drive successful implementations, ensuring stakeholder align...
Today
$120K - $180K *
Shape the future of neuroscience by leveraging AI to enhance research methodologies. Collaborate with experts to define benchmarks, analyze data, and ensure AI agents meet rigorous scientific standard...
3 weeks ago
$201K - $251K *
Lead strategic forecasting initiatives to drive decision-making in oncology. Collaborate with cross-functional teams to develop long-term models and communicate insights that shape product and portfol...
3 weeks ago
Senior Program Manager, Life Sciences
$170K - $200K *
Lead the charge in managing complex Life Sciences programs, ensuring alignment with customer commitments. Drive delivery across teams, proactively addressing risks and building a PMO as the business s...
1 week ago
Director, Application & Technical Service
$135K - $160K *
Drive a unified technical organization to enhance customer support from application discovery to project conversion, focusing on team development, technical selling, and improving customer experiences...
1 week ago
Director, Application & Technical Service
$135K - $160K *
Lead the charge in building a unified technical organization that enhances customer experience through application support and field service, driving project conversions and fostering a culture of con...
1 week ago
Principal AI Solutions Engineer
$132K - $173K *
Architect AI-driven solutions that enhance business processes and decision-making. Collaborate with cross-functional teams to design, develop, and deploy scalable applications, ensuring compliance wit...
1 month ago
$110K - $130K *
Lead the quality assurance efforts for commissioning, qualification, and validation across multiple manufacturing sites, ensuring compliance with cGMP standards while collaborating with cross-function...
3 weeks ago
$80K - $95K *
Support project management by coordinating study documentation, mentoring team members, and ensuring compliance. Leverage expertise in clinical research to enhance study start-up and execution, while...
2 weeks ago
$275K - $325K *
Join a team that's redefining financing products through innovative engineering. Lead complex initiatives, modernize systems, and leverage AI tools to enhance software development while ensuring data...
6 days ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.