Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$186K - $232K *

Innovate within a dynamic team by establishing bioinformatics capabilities, architecting scalable infrastructure, and enhancing genomic algorithms to drive excellence in women's and organ health produ...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$173K - $312K *

Empower organizational growth by leading global learning strategies, aligning workforce capabilities with business goals, and driving innovative solutions. Collaborate with senior leaders to enhance l...

Reposted 4 days ago

  •   8 - 10 years exp.  •   Healthcare

$173K - $312K *

Elevate global learning initiatives by leading strategy, governance, and innovation. Collaborate with senior leaders to identify capability gaps and drive impactful learning solutions that align with...

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$136K - $214K *

Lead the charge in optimizing revenue operations by managing a dynamic team, enhancing forecasting processes, and ensuring data integrity across systems. Collaborate closely with sales leadership to d...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $170K *

Join a team that's redefining production excellence by leading end-to-end photo and video shoots. You'll manage budgets, build partnerships, and create efficient workflows while ensuring brand integri...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$92K - $138K *

Unlock your potential by joining a dynamic team focused on delivering top-notch Ultrasound IT support. Collaborate with customers to resolve complex technical issues in a fast-paced environment, ensur...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$120K - $140K *

Drive product innovation in healthcare revenue cycle management by optimizing eligibility verification and enhancing payer connections. Collaborate with clients and internal teams to ensure effective...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $180K *

Accelerate progress at the forefront of AI-native software development. Drive engineering excellence by orchestrating autonomous agents and maintaining high-quality standards in a FedRAMP-authorized e...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Elevate operational efficiency by leading shared service improvements and cross-functional collaboration to enhance patient and provider experiences while driving team performance and process excellen...

North Carolina, USRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive strategic leadership in clinical quality and research programs, enhancing patient engagement and operational excellence. Oversee program development, compliance, and partnerships to foster innov...

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$250K - $300K *

Lead a dynamic team of radiologists in a remote setting, managing diverse caseloads including inpatient and outpatient cases. Enjoy a supportive culture with growth opportunities and a compensation mo...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Optimize property performance through strategic maintenance leadership, driving safety culture and sustainability. This impactful role necessitates technical expertise and frequent travel to ensure ex...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$250K - $275K *

Lead multi-domain technical strategies and solutions, guiding clients to align technology with business goals. Mentor teams while owning solution architecture through the entire lifecycle, ensuring co...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$79K - $118K *

Transform patient care by leading the Navigator Program, ensuring quality and efficiency in service delivery while fostering community relationships and continuous improvement in healthcare outcomes...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a dynamic team as a strategic HR Business Partner, supporting global entities. Drive employee relations, performance management, and culture integration while guiding HR initiatives across divers...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$77K - $106K *

Join a team that's dedicated to providing personalized home health care, managing patient recovery plans, and collaborating with healthcare professionals to enhance patient independence and well-being...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$500K+*

Join a team that's dedicated to providing high-quality radiology services. This fully remote role offers flexible scheduling, competitive compensation, and opportunities for partnership growth in a su...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$500K+*

Transform your career as a Remote General Radiologist, enjoying flexible daytime shifts and a supportive team. Join a progressive practice focused on clinical excellence and long-term growth, with opp...

New Bern, NCRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $100K *

Empower innovation by developing secure web applications as a Full Stack Developer. Work collaboratively across frontend and backend components, enhancing functionalities while supporting mission-driv...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$70K - $110K *

Champion the B2B2C CRM strategy, driving engagement and retention while leading execution for key accounts. Balance hands-on Braze work with strategic oversight, coaching a CRM Manager to optimize per...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Elevate your career by providing engineering and consulting services for diverse environmental projects. Lead site investigations, design systems, and ensure compliance while collaborating with client...

3 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$90K - $178K *

Transform the patient engagement landscape in clinical trials by developing and delivering strategic support initiatives. Partner with diverse stakeholders to enhance participation and optimize patien...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Drive excellence in pharmacy operations by ensuring accurate medication dispensing, compliance with regulations, and effective team leadership. Collaborate with healthcare professionals to enhance pat...

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Empower legal firms by leading the development of innovative IT solutions, driving market strategies, and enhancing service offerings. Collaborate with cross-functional teams to establish credibility...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$237K - $296K *

Join a team that's driving innovation in oncology by leading clinical development and medical affairs. Collaborate across functions to advance pivotal programs and ensure operational excellence in a f...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.