Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$180K - $215K *

Transform your career by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster strong cus...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Join a dynamic team and drive mission success in government relations by managing relationships, orchestrating initiatives, and ensuring compliance in a fast-paced environment. Your expertise will dir...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$110K - $130K *

Transform clinical operations by leading a dynamic team, ensuring high-quality trial management, and driving innovation through technology and AI solutions. Your strategic oversight will enhance perfo...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$170K - $235K *

Drive the design and implementation of backend services to enhance customer experiences across NodeZero’s licensing, provisioning, and admin systems. Lead efforts to ensure accuracy, scalability, and...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$176K - $230K *

Lead the charge in transforming healthcare through data-driven solutions. As a Senior Data Scientist, you'll spearhead projects that enhance patient outcomes, leveraging your expertise to align data s...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $125K *

Join a team that's focused on building and enhancing relationships with large managed care accounts. Utilize your expertise in account management to drive customer satisfaction, explore upselling oppo...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Staffing

$100K - $120K *

Partner with us to drive strategic healthcare marketing initiatives. Lead client relationships, oversee peer-to-peer programs, and mentor team members to ensure compliance and achieve results while fo...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$222K - $292K *

Elevate patient outcomes by leading global evidence strategies that showcase the value of therapies. Collaborate across functions to drive research programs, influence decision-making, and ensure scie...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Lead the charge in delivering complex federal digital services programs, ensuring strategic direction, operational excellence, and strong customer relationships across multidisciplinary teams while ma...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $125K *

Empower healthcare compliance by enhancing programs, mitigating risks, and driving operational integrity. Collaborate with diverse clients to deliver tailored solutions in a dynamic regulatory landsca...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$110K - $130K *

Lead proactive cybersecurity investigations, analyze threats, and enhance detection capabilities. Collaborate with teams to improve incident response and operational resilience while utilizing advance...

Yesterday

  •   Less than 5 years exp.  •   Staffing

$80K - $95K *

Join a team that's dedicated to enhancing resident care through effective infection prevention and clinical services. Leverage your nursing expertise to lead initiatives that ensure safety and complia...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$117K - $160K *

Lead the charge in underwriting E&S commercial property and casualty accounts. Manage risk assessments, develop competitive quotes, and collaborate with carriers to optimize profitability while achiev...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Drive operational excellence by developing and maintaining standards, ensuring consistency across markets, and collaborating with cross-functional teams to enhance processes and documentation for opti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $175K *

Shape exceptional user experiences by leading design for a unified legal platform. Drive user-centered solutions through research, collaboration, and design leadership to meet the complex needs of leg...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $110K *

Join a dynamic team of healthcare professionals to provide comprehensive patient care, including primary, urgent, and pain management services. Utilize your clinical skills to build relationships and...

5 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$107K - $213K *

Oversee site activation projects, ensuring timely delivery, effective communication, and compliance with regulations. Lead cross-functional teams to meet goals and address challenges, driving strategi...

Durham, NCRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $100K *

Lead operations in a dynamic long-term care facility, ensuring regulatory compliance and high-quality resident care. Drive financial performance and foster a culture of accountability across departmen...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $175K *

Accelerate patient care by optimizing therapy pathways and engaging key stakeholders. Collaborate with healthcare teams to enhance VTE awareness and program development, driving clinical initiatives a...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Lead the operational execution of a patient support program, ensuring high-quality service delivery and compliance. Drive strategic planning, team development, and continuous improvement initiatives t...

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Drive operational excellence in patient support programs, enhancing access and outcomes through strategic leadership, compliance, and team development. Oversee key functions to ensure a patient-center...

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$103K - $154K *

Unlock advanced data solutions by leveraging Microsoft Azure and Power BI. Collaborate with teams to deliver high-quality analytics and reporting, while enhancing business intelligence capabilities th...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$100K - $130K *

Join a dynamic team to lead and enhance billing and coding operations, ensuring quality and compliance across multiple markets. Drive performance, coach leaders, and collaborate cross-functionally to...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$140K *

Join a team that's dedicated to delivering innovative mental health care through comprehensive evaluations and tailored treatment plans, utilizing advanced techniques in a collaborative, fast-paced en...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $100K *

Lead the delivery of high-quality ABA therapy in a hybrid role, balancing remote and in-person client engagement. Collaborate with clinical teams to develop individualized behavior plans and support f...

5 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.