Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$95K - $115K *

Engage with clients to transform complex Enterprise Architecture needs into actionable solutions. Manage implementation workstreams, ensuring effective onboarding and training while fostering strong r...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Lead the charge in driving brand awareness and revenue growth for Cryo Nerve Block products. Oversee a team of Territory Managers and Clinical Specialists, utilizing data analysis to strategize and en...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $190K *

Champion innovative technical solutions as you lead the architecture and implementation on cutting-edge projects. Collaborate with clients and cross-functional teams to ensure successful delivery and...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$105K - $130K *

Join a team that's redefining billing solutions in the legal sector. Leverage your expertise in law firm financial operations to support sales efforts, conduct client demos, and enhance our innovative...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$78K - $168K *

Join a leading retail health care provider to deliver high-quality, evidence-based patient care. Enjoy autonomy, flexible scheduling, and comprehensive support while engaging in both in-person and vir...

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$142K - $195K *

Pioneer innovative technology strategies that align business vision with IT execution. Collaborate across teams to drive enterprise architecture modernization and deliver impactful solutions while men...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$88K - $134K *

Shape the future of customer success by leading the deployment of IoT solutions for enterprise clients. Your role will bridge sales and strategy, ensuring clients maximize the value of their technolog...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's transforming medicine by engaging with KOLs and healthcare professionals. Leverage your clinical expertise to communicate product benefits, support education, and drive strategic in...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$420K - $476K *

Elevate your career by driving Employer Sales growth, shaping go-to-market strategies, and building a high-performing sales organization. This strategic role requires strong leadership and expertise i...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$172K - $210K *

Architect and lead customer-focused application development initiatives, translating business needs into robust software solutions. Leverage modern technologies and AI tools to ensure high-quality, se...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Business Services

$90K - $110K *

Transform patient care by delivering comprehensive assessments and treatments. Collaborate with a dedicated team to enhance patient satisfaction and ensure efficient healthcare delivery in a dynamic e...

Today

  •   Less than 5 years exp.  •   Healthcare

$74K - $137K *

Lead the charge in transforming workflows with AI, driving adoption and measurable impact in legal, tax, and trade sectors. Collaborate with clients and teams to design, implement, and evaluate innova...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$210K - $250K *

Drive enterprise-wide physician leadership and clinical oversight for government healthcare programs. Ensure high-quality, compliant healthcare services across federal detention facilities with a focu...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Staffing

$73K - $105K *

Join a dynamic team to lead and scale Managed Payroll services, shaping operations and enhancing customer experience. Drive team development, streamline processes, and leverage technology to deliver e...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$220K - $298K *

Transform chronic weight management strategies on a global scale, driving evidence generation and medical communication while leading cross-functional collaboration to deliver impactful healthcare sol...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$117K - $160K *

Champion profitable growth by managing E&S commercial property and casualty underwriting. Leverage strong technical skills and relationships to assess risks, deliver competitive quotes, and optimize p...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $180K *

Lead the charge in innovative healthcare architecture by overseeing project design, ensuring compliance, and fostering collaboration among teams to deliver exceptional results in a dynamic environment...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $180K *

Transform healthcare architecture by leading project design and documentation, ensuring stakeholder collaboration, and delivering innovative solutions in a dynamic team environment. Drive excellence i...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Lead the design and implementation of robust security measures to protect sensitive health information, ensuring compliance with HIPAA and other regulations while collaborating with cross-functional t...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$89K - $133K *

Empower success by leading healthcare technology implementations, optimizing workflows, and ensuring compliance. Collaborate across teams to guarantee smooth integrations and enhance system functional...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Analyze and evaluate network anomalies in a 24/7 SOC environment. Collaborate with analysts on cyber threats, develop incident reports, and enhance SOC processes. Build test labs for research and prov...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $140K *

Innovate cloud solutions by designing and automating infrastructure in Cloud.gov and Azure. Collaborate with teams to enhance performance and security, driving impactful results for clients while shap...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Elevate your career by driving ERP innovation and optimization. Collaborate with stakeholders to enhance Workday and corporate applications, ensuring seamless integration and maximum value delivery ac...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$83K - $103K *

Drive success in regulatory affairs by preparing critical submissions for medical and diagnostic devices. Oversee compliance with U.S. and international regulations while collaborating with cross-func...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Drive regional sales success by leading a high-performing team, executing launch strategies, and fostering customer relationships to achieve business objectives in a dynamic environment...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.