Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$88K - $105K *

Lead the charge in delivering innovative healthcare projects, guiding design excellence from concept to construction. Collaborate with teams, manage quality assurance, and mentor staff to achieve proj...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$95K - $115K *

Partner with us to enhance pediatric care by providing expert support in clinical settings. Utilize your skills to manage acute and chronic health conditions, ensuring quality service for children and...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Transform patient care by joining our dedicated team, fostering collaboration and community engagement while ensuring a safe, inclusive environment for all. Your commitment to quality and teamwork wil...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $106K *

Transform patient care by developing and implementing comprehensive nursing plans in home health settings, ensuring high-quality clinical coordination and compliance with regulations while collaborati...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Champion the development and execution of mission command training, mentoring unit leaders to enhance operational proficiency across various training domains. Collaborate with senior staff to ensure e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$274K - $371K *

Elevate patient care through innovative clinical strategies in obesity and cardiometabolic development. Collaborate across teams to design and implement late-phase studies, ensuring alignment with glo...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$88K - $95K *

Drive operational excellence by leading projects across teams, enhancing efficiency, managing stakeholders, and ensuring timely delivery. Collaborate within a dynamic environment dedicated to improvin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $170K *

Partner with us to enhance consultant relationships in healthcare. Drive business growth by cultivating partnerships, optimizing engagement strategies, and aligning internal teams to effectively posit...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$114K - $212K *

Drive the transformation of manual operations into a Smart Factory model by leading the comprehensive robotics program, integrating advanced automation technologies, and ensuring seamless operations a...

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Oversee resident care services, ensuring compliance with regulations and policies. Develop and implement care plans, coordinate with healthcare professionals, and train staff while maintaining high st...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $118K *

Lead the charge in delivering exceptional patient care as a skilled RN, coordinating comprehensive nursing services in a dynamic medical-surgical unit. Collaborate with a dedicated team to ensure safe...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$123K - $168K *

Unlock potential by driving product growth and building relationships with healthcare providers. This role requires strategic account management and effective communication to educate stakeholders on...

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Unlock potential by collaborating across teams to drive data integrity and safety in oncology clinical studies while developing comprehensive medical review plans and managing project deliverables...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $190K *

Lead the charge in driving business excellence initiatives across Global Patient Safety. Collaborate with cross-functional teams to enhance project management, governance, and operational effectivenes...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Drive strategic leadership in quality improvement and clinical transformation initiatives across community health centers, enhancing patient outcomes and operational performance while fostering a cult...

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $100K *

Shape your career by optimizing Workday solutions across Benefits, Compensation, and Reporting. Collaborate with HR and IT to enhance system functionality, troubleshoot issues, and drive continuous im...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$95K - $115K *

Transform clinical quality by supporting training initiatives, monitoring clinician performance, and ensuring compliance with quality standards for successful operational processes and clinician suppo...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$141K - $172K *

Tackle operational challenges by leading large-scale project management initiatives, driving efficiency, and fostering client relationships to optimize growth and sustainability in critical infrastruc...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Technical Services

$122K *

Elevate your career by managing global projects in Neuroscience, ensuring compliance, budget adherence, and successful collaboration across cross-functional teams to drive milestone achievement and en...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $185K *

Shape the future of video content at a tech-driven company. Lead the charge in creating, managing, and delivering high-quality video assets for a developer audience, while collaborating with cross-fun...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Engage in pharmaceutical care by interpreting physician orders, ensuring accuracy, and providing essential drug information to customers while fostering collaboration and communication across healthca...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$79K - $118K *

Join a team that's dedicated to delivering exceptional patient care across multiple facilities. As a Resource Registered Nurse, you'll utilize your clinical expertise to assess, plan, and implement nu...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Advance patient care by conducting comprehensive assessments and managing hospice plans. Collaborate with a dedicated team to ensure continuity and quality of care in a supportive environment focused...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Help us enhance federal human capital operations through independent analysis, strategic recommendations, and effective program delivery. Collaborate on data-driven insights to improve efficiency and...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $220K *

Drive security excellence by leading a dynamic team to enhance our cloud platform's security posture. Collaborate across departments to ensure compliance, resilience, and customer trust while fosterin...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.