Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$170K - $210K *

Empower Federal agencies by architecting and delivering AI-assisted software solutions. Responsible for client engagement, technology integration, and ensuring that production-ready solutions meet ope...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$85K - $117K *

Empower patients by delivering personalized speech therapy services in home settings. Collaborate with healthcare teams to develop treatment plans, assess progress, and enhance communication skills, e...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$210K *

Elevate patient health by delivering comprehensive virtual OB/GYN care. Manage diverse clinical cases via telemedicine while ensuring work-life balance and providing compassionate support across North...

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $150K *

Elevate pediatric dental care by joining our collaborative team, where you'll provide exceptional treatment to children in a supportive, high-volume practice. Enjoy a fulfilling role that fosters last...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$120K - $144K *

Join a team that's dedicated to providing exceptional dental care to children. This role offers the chance to build lasting relationships in a supportive, multi-doctor environment while utilizing mode...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$80K - $90K *

Drive patient-centered care by collaborating with nephrology practices to enhance outcomes for high-risk CKD and ESKD patients through outreach, education, and care coordination in various settings...

Today

  •   Less than 5 years exp.  •   Healthcare

$172K - $223K *

Champion operational excellence as a strategic leader, driving performance and financial results across the PacWest Region while ensuring safety, quality, and compliance in a mission-driven environmen...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$125K - $235K *

Drive operational excellence in healthcare by leading transformative initiatives, optimizing workflows, and enhancing provider productivity. Collaborate with teams to deliver data-driven solutions tha...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$225K - $281K *

Join a team that's pushing the boundaries of oncology research! This key role involves designing and leading clinical trials, ensuring data integrity, and collaborating with global experts to advance...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$225K - $281K *

Explore your career in clinical development as you design and lead innovative oncology studies, ensuring data integrity and compliance while collaborating with cross-functional teams and cultivating r...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$200K - $215K *

Advance the cloud platform capabilities, ensuring secure, reliable, and scalable product delivery while enhancing developer experience and shaping reliability practices in a mission-driven healthcare...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in strategic decision-making and daily operations, ensuring quality and cost-effectiveness while fostering community relations and promoting organizational goals through effective mana...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Support clients in maximizing their Workday investment by implementing and enhancing Adaptive Planning solutions. Drive project success through relationship building, best practices, and exceptional s...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$90K - $110K *

Engage in comprehensive patient care as a Nurse Practitioner, collaborating with physicians to implement treatment plans, mentor staff, and ensure high-quality medical services in an integrated care t...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive the strategic direction and operational performance of our Ambulatory Surgery Center, ensuring high-quality patient care, financial sustainability, and compliance with regulatory standards while...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$184K - $396K *

Lead our clinical strategy in the West Region, driving performance in cost, quality, and member experience through partnerships with healthcare providers. Collaborate with teams to enhance value-based...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Reimagine cloud infrastructure as you build and operate scalable systems that empower product teams. Ensure reliability and speed in a dynamic environment, supporting enterprise-scale solutions for Fo...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Join a team that's shaping the future of environmental engineering. Lead diverse projects, drive business development, and mentor professionals while ensuring compliance and client satisfaction across...

3 days ago

  •   8 - 10 years exp.  •   Business Services

$157K - $256K *

Champion strategic engagements with oncology thought leaders to enhance insights and drive initiatives for our Solid Tumor portfolio, focusing on collaboration across teams and executing regional stra...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$123K - $168K *

Explore the potential of Neurocrine products by managing key accounts, driving sales growth, and fostering relationships with healthcare professionals. Collaborate cross-functionally to enhance produc...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$140K - $187K *

Innovate the future of AI security by designing and implementing robust defenses against adversarial threats, ensuring the integrity of AI systems while fostering innovation and collaboration across c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$109K - $144K *

Reimagine healthcare technology as an Application Analyst supporting Epic Professional Billing. Leverage your expertise in revenue cycle operations to optimize billing accuracy and enhance workflow ef...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $180K *

Join us to lead our accounting operations, ensuring accuracy and scalability. Drive financial reporting, audits, and team development while applying your technical expertise in a dynamic, multi-channe...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $175K *

Advance application security initiatives by leading manual code reviews, penetration tests, and threat modeling. Work closely with clients to strengthen their secure development processes, delivering...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $115K *

Transform patient care by joining our dedicated team of therapists. Enjoy flexible scheduling, competitive compensation, and a supportive environment while making a meaningful impact on diverse popula...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.