Find $100K+ Jobs in Massachusetts

Explore professional opportunities across Massachusetts with Ladders. Browse vetted jobs paying $100,000 or more, from roles in Boston and Cambridge to opportunities in Worcester, Springfield, and other communities throughout the state. Whether you’re pursuing your next leadership position or advancing your career in a specialized field, discover openings that match your experience and goals.

Explore Massachusetts Career Opportunities

Massachusetts is home to a diverse economy with employers in technology, healthcare, financial services, education, biotechnology, manufacturing, and professional services. Job availability and compensation vary by employer, role, and experience. Use Ladders to explore current openings and identify opportunities aligned with your skills.

Search by Location and Specialty

Focus your search on major employment centers such as Boston, Cambridge, and Worcester, or look across the state for roles that fit your preferences. Refine your search by job title, industry, seniority, and other relevant criteria to find opportunities suited to your career direction.

Advance Your Career with Ladders

Ladders specializes in vetted professional jobs paying $100,000 or more. Review listings, compare role requirements, and apply to positions that align with your qualifications. Set up a complete profile and keep your resume current to make it easier to pursue your next Massachusetts opportunity.

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$170K - $220K *

Shape the future of customer solutions by leading implementations and driving adoption of innovative technologies. Collaborate with teams to deliver tailored architectural designs that meet strategic...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$155K - $165K *

Join a team that's dedicated to enhancing resident care by leading nursing staff, ensuring quality standards, and fostering a compassionate environment. Your expertise will drive improvements and supp...

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$100K - $125K *

Manage a team of medical writers to develop impactful scientific content, ensuring accuracy and compliance. Collaborate with clients and cross-functional teams to drive medical strategies and delivera...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $220K *

Transform LLM inference efficiency by leading the performance measurement, diagnosis, and enhancement efforts to optimize customer experience through cost-effective and speedy solutions in a hands-on...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$156K - $235K *

Accelerate your career by leading Theranostics initiatives within a national healthcare advisory team. Collaborate with executives to enhance patient outcomes and operational performance through strat...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$88K - $96K *

Drive your career with a vital role managing strategic customer relationships and maximizing revenue opportunities in existing accounts through relationship selling and innovative solutions. Ideal for...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$245K - $265K *

Shape the future of neurology by building partnerships with Medical Experts, driving insights, and collaborating across teams to enhance patient care and strategic initiatives in a dynamic healthcare...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's at the forefront of cybersecurity, leading advanced incident response efforts. As a senior operational lead, you'll coordinate critical responses, ensuring effective communication a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$174K - $374K *

Lead the charge in clinical oversight and mentorship, driving innovative medical solutions across diverse programs. Collaborate with cross-functional teams to ensure evidence-based decision-making and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$89K - $170K *

Pioneer innovative software solutions by developing and maintaining high-quality applications. Collaborate within a cross-functional team to enhance system performance and reliability, ensuring except...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$210K - $250K *

Innovate with us to enhance patient safety in global clinical studies. As a key medical expert, you'll provide critical input, oversee trial safety, and collaborate with teams to ensure compliance and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Champion a high-performing global team of Solution Consultants, driving technical pre-sales strategy and enhancing ServiceNow's OT/CPS portfolio. Engage with customers to connect industrial operations...

Boston, MARemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$159K - $243K *

Collaborate with strategic partners to drive business growth, enhance sales capabilities, and execute comprehensive business plans. Leverage existing relationships to maximize partner engagement and a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $110K *

Drive strategic GTM initiatives and optimize operations across teams. Collaborate with leadership to enhance revenue processes, leveraging AI tools and data insights to ensure alignment and execution...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$122K *

Champion project success by leading interdisciplinary teams to deliver innovative solutions in the biotech and pharma sectors. Drive milestone achievement, manage budgets, and ensure compliance with p...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a dynamic team to enhance client implementations of the Charles River IMS, ensuring optimal integration and collaboration across various stakeholders while fostering strong client relations and d...

4 weeks ago

  •   Less than 5 years exp.  •   Business Services

$242K - $403K *

Lead global companion diagnostics strategy, integrating diagnostic plans with clinical development and regulatory objectives. Drive execution across therapeutic programs, ensuring alignment with patie...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$116K - $182K *

Join a team that's shaping the future of clinical development by leading cross-functional teams to drive innovative strategies that ensure the successful approval of groundbreaking therapies across mu...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$174K - $203K *

Empower clinical innovations by leading statistical strategies in oncology trials. Collaborate with cross-functional teams to design studies, analyze data, and support regulatory submissions, ensuring...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$117K - $201K *

Empower scientific innovation by leading the design and validation of agent-enabled workflows in cheminformatics. Collaborate with cross-disciplinary teams to enhance drug discovery processes and driv...

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $215K *

Champion fund governance and legal compliance for investment companies. Leverage your expertise in the Investment Company Act to manage regulatory filings, oversee board meetings, and collaborate with...

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Manage and lead field-based medical teams, ensuring client delivery and team performance while fostering scientific engagement and program growth. Collaborate with cross-functional teams to achieve st...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $210K *

Lead the charge in advancing research for coaching practices, ensuring scientific integrity, guiding educational strategies, and mentoring future research leaders to enhance the Institute's credibilit...

Belmont, MARemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Help us establish a new 24/7 Midwifery and Gynecology APP coverage model, providing high-quality women's health care in a collaborative, multidisciplinary environment while practicing to the full exte...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Empower clinical operations by providing support and supervision during evening, night, and weekend shifts. Ensure continuity of care, address potential issues, and investigate incidents to enhance pa...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include professional and leadership roles across fields such as technology, healthcare, finance, biotechnology, education, manufacturing, and business services. Available positions change, so browse current listings for the latest opportunities.

  • Where can I find professional jobs in Massachusetts?question toggle

    Search across the state, including major employment centers such as Boston, Cambridge, and Worcester. You can also use location filters to explore roles in other Massachusetts communities.

  • Are the Massachusetts jobs on Ladders vetted?question toggle

    Ladders features vetted professional job listings paying $100,000 or more. Review each listing for details about the employer, responsibilities, qualifications, and compensation.

  • How can I find a Massachusetts job that matches my experience?question toggle

    Use filters such as location, job title, industry, and seniority to narrow your search. Keep your resume current and compare each listing’s requirements with your skills and career goals.