Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$90K - $110K *

Join a dynamic team to lead the development and operations of an insurance network, focusing on agency recruitment, relationship management, and service delivery to enhance member success and drive or...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Empower consumer experiences by leading product strategy and execution for innovative genomics solutions. Collaborate with cross-functional teams to enhance user satisfaction and drive adoption throug...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$185K - $230K *

Advance patient access and reimbursement strategies in rare diseases. Collaborate cross-functionally to educate providers and support patients, ensuring compliance and effective navigation of complex...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform the insurance appeals process by managing, researching, and drafting compliant responses to billing deductions. Collaborate with legal teams to enhance efficiency and build strong relationsh...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Legal & Accounting

$140K - $185K *

Unlock the power of enterprise data as you design and implement Master Data Management solutions that enhance healthcare operations, drive analytics, and enable AI-driven decision-making with trusted...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$136K - $230K *

Elevate customer success by delivering Professional Services engagements, including installation, migration, and training, while collaborating with project managers to enhance delivery consistency and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$164K - $305K *

Join a team that's redefining account management by driving growth and retention for complex health systems. Build strategic relationships with C-suite executives and lead cross-functional teams to de...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$163K - $203K *

Lead the charge in executing compliance strategies across regulated sectors, ensuring robust oversight and operational clarity while collaborating with cross-functional teams to navigate regulatory la...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$82K - $112K *

Shape compelling product narratives by leveraging market insights and AI tools. Collaborate cross-functionally to drive go-to-market strategies, ensuring impactful messaging and training materials tha...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $192K *

Drive success by managing strategic merchant partnerships, blending account management and operations to enhance performance and growth. Collaborate cross-functionally to deliver scalable solutions an...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Transportation

$110K - $130K *

Lead the optimization of cross-pillar workflows, ensuring technical soundness and operational effectiveness. Collaborate with engineering and product teams to enhance product adoption and drive measur...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$173K - $310K *

Transform clinical AI solutions by leveraging your expertise in patient care and research. Collaborate cross-functionally to enhance clinical accuracy and support strategic partnerships, ensuring the...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$143K - $185K *

Unlock potential by leading clinical data management for innovative cell therapy studies. Collaborate cross-functionally to ensure data integrity and compliance while managing teams and external partn...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Join a team that's redefining sales excellence by driving revenue growth and market expansion for innovative SynBio products. Lead a dynamic team, develop strategies, and enhance customer experiences...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$220K - $240K *

Optimize customer success through strategic leadership and analytics, guiding a global team to deliver exceptional customer experiences and drive market growth in the Resins & Technologies sector...

RemoteRemote

1 month ago

  •   8 - 10 years exp.  •   Business Services

$120K - $145K *

Lead the charge in defining and activating brand strategies across multiple channels, enhancing donor engagement and retention through innovative content and social communications while collaborating...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $250K *

Lead the charge in executing clinical outsourcing strategies across oncology trials, managing vendor relationships, contract negotiations, and financial oversight to ensure optimal performance and com...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$187K - $233K *

Support compliance for AI products by advising cross-functional teams, ensuring regulatory adherence, and shaping governance frameworks. Lead compliance initiatives, mentor colleagues, and drive produ...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $151K *

Champion operational excellence by ensuring radiation safety and EHS compliance across cyclotron manufacturing and PET nuclear pharmacy facilities in the South Central US, while collaborating with cro...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Develop and nurture partnerships with school districts to drive product adoption, enhance customer success, and ensure long-term retention through strategic implementation and proactive engagement...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$136K - $181K *

Take ownership of CRA management by leading teams, developing metrics, and ensuring compliance with monitoring standards. Drive continuous improvement and optimize effectiveness across the Site Manage...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Empower medical initiatives by leading project teams, providing strategic guidance, and ensuring compliance with regulatory standards while fostering high-performing teams in a dynamic environment...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Manage the operational backbone of multiple HCI portfolios by coordinating and executing initiatives, engaging with diverse stakeholders, and overseeing project timelines, budgets, and deliverables fo...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $190K *

Join a team that's dedicated to advancing precision medicine by leveraging AI to provide cutting-edge educational support and scientific expertise on cancer biomarker tests while engaging key opinion...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $135K *

Collaborate with leaders to manage employee relations and complex investigations, providing expert guidance and risk assessments in a dynamic, regulated environment. Drive best practices and support w...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.