Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Manager, Underwriting Unit Lead
$67K - $182K *
Lead the charge in driving operational excellence and strategic direction for a high-performing underwriting team, ensuring quality Medicare underwriting services that support profitable growth and bu...
2 weeks ago
$103K - $123K *
Drive growth by managing a sales territory, building relationships, and generating premium. Leverage existing partnerships while prospecting new agencies to achieve targets and expand market presence...
1 week ago
Sr. Director/Director Business Development (Plasmid DNA and Protein CDMO)
$190K - $210K *
Advance business growth by developing and executing sales strategies in the Plasmid DNA and Viral Vector markets, while fostering strong client relationships and driving revenue through a client-cente...
4 weeks ago
Account Executive - Government
$80K - $95K *
Grow your career by developing and maintaining key customer relationships, driving sales success, and collaborating with teams to exceed goals. Leverage your expertise in account management and sales...
2 weeks ago
$192K - $243K *
Champion customer success by leading a dynamic team to drive post-live growth, retention, and expansion initiatives within enterprise software, influencing retailer P&L outcomes and ensuring a consult...
Reposted 4 weeks ago
$111K - $150K *
Transform product strategy and execution by leveraging data insights, leading cross-functional teams, and prioritizing customer needs to drive product success and business growth in a dynamic environm...
3 weeks ago
Program Specialist, Care Management
$74K - $119K *
Transform healthcare delivery by coordinating strategic programs that enhance clinical and operational excellence. Collaborate with diverse teams to implement innovative solutions, ensuring compliance...
1 week ago
$200K - $300K *
Drive product strategy and lifecycle management, ensuring alignment with market needs and business growth. Lead cross-functional teams to develop, launch, and support innovative medical devices while...
Reposted 2 days ago
$250K - $290K *
Champion growth by developing best-in-class business practices, leading a high-performing new business team, managing pipeline opportunities, and fostering strategic partnerships with leadership to dr...
Reposted 1 week ago
Specialist Seller, Enterprise Core (Tracking Label)
$222K - $278K *
Empower businesses by eliminating supply chain blind spots. Drive adoption of our innovative Tracking Label product, collaborating with Enterprise teams to enhance shipment visibility and security acr...
3 days ago
Forward Deployed Process Consultant- R37
$113K - $226K *
Lead the charge in optimizing healthcare processes by bridging strategy and execution. Collaborate with teams to enhance coding workflows, drive change management, and ensure alignment with strategic...
2 weeks ago
$100K - $120K *
Innovate your career by building agile marketing systems that leverage AI and data. Own the demand generation engine, connecting audience insights and multi-channel campaigns to drive measurable growt...
2 weeks ago
$201K - $251K *
Transform workforce intelligence by leading People Analytics, establishing data governance, and driving strategic decision-making in a high-growth environment. Collaborate across functions to enhance...
3 weeks ago
Regional Business Director, Greatlakes
$230K - $260K *
Oversee regional sales strategies and lead a team to drive oncology product sales. Collaborate cross-functionally to enhance market insights and ensure compliance while fostering team development and...
1 week ago
Director, GxP Quality Governance and Partnerships
$201K - $251K *
Champion Quality governance by leading the development and management of Quality Agreements across global operations, ensuring compliance and effective partnerships with internal and external stakehol...
Yesterday
Territory Sales Representative, Essential Dentistry
$70K - $120K *
Drive sales success by building relationships with dental professionals, promoting innovative products, and achieving targets. Leverage your expertise to deliver exceptional customer service and suppo...
Reposted 3 days ago
Senior Scientific Director (Virology)
$150K - $180K *
Lead the charge in developing and overseeing scientific content across multiple therapeutic areas, ensuring high-quality contributions and strategic client interactions to drive growth and innovation...
4 weeks ago
Field Application Scientist, Pathway & NGS Analysis Software, QDI
$100K - $124K *
Lead the charge in delivering impactful scientific software demonstrations and training. Collaborate with diverse teams to address customer needs and enhance bioinformatics solutions, driving innovati...
2 weeks ago
$76K - $148K *
Play a key role in managing clinical trials, ensuring compliance and quality oversight of project deliverables while collaborating with cross-functional teams to meet timelines and budget goals...
Reposted 1 week ago
Regional Clinical Study Manager
$136K - $181K *
Lead the charge in regional clinical study delivery, ensuring quality and compliance while managing timelines and budgets. Collaborate with teams and stakeholders to drive operational excellence and e...
3 weeks ago
Regional Clinical Study Manager
$118K - $158K *
Lead the charge in regional clinical study delivery, ensuring quality and compliance while managing timelines and budgets. Collaborate with stakeholders and oversee external partners to drive successf...
3 weeks ago
Principal Data & AI Platform Engineer, DataOps
$200K - $230K *
Elevate data operations by architecting AI-driven solutions that enhance resilience, scalability, and intelligence in data processing systems. Lead cross-functional teams to implement innovative DataO...
2 weeks ago
$175K - $210K *
Elevate your career by owning the sales cycle for major employers, building strategic partnerships, and driving innovative health programs that shape enterprise success and market presence...
1 month ago
$170K - $185K *
Join a dynamic team to define and lead product strategy for Family Building Navigation, enhancing member engagement through innovative digital experiences and personalized support while collaborating...
6 days ago
Senior Consultant - Healthcare Compliance
$100K - $125K *
Empower healthcare compliance by enhancing programs, mitigating risks, and driving operational integrity. Collaborate with diverse clients to deliver tailored solutions in a dynamic regulatory landsca...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.