Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Regional Vice President of Commerce
$150K - $180K *
Transform your career by driving new revenue growth in diverse industries. As a key sales leader, you'll identify prospects, develop relationships, and deliver tailored marketing solutions, ensuring c...
2 weeks ago
Global Dx Clinical Pathologist
$106K - $172K *
Elevate veterinary care by interpreting digital cytology and hematology cases. Collaborate with veterinarians, ensure quality control, and contribute to outreach efforts while maintaining high standar...
1 week ago
$110K - $130K *
Unlock financial potential by analyzing complex healthcare contracts and data. Collaborate with health systems to translate insights into measurable outcomes, driving operational value and shaping AI...
1 week ago
Regulatory Affairs Director (Remote - United States)
$211K - $290K *
Champion global regulatory strategies to drive product approvals and market access for innovative dental solutions. Collaborate with cross-functional teams to navigate complex regulatory landscapes an...
3 days ago
Director of Data Analytics and Solutions
$125K - $156K *
Drive data excellence by leading analytics initiatives, enhancing governance, and integrating systems. Collaborate with leadership to deliver impactful insights and ensure compliance while leveraging...
1 week ago
Oncology Sales Specialist - OR and So. ID
$235K - $270K *
Transform the landscape of oncology sales by driving growth within your territory. Collaborate with sales teams to identify opportunities, engage with key accounts, and promote cutting-edge diagnostic...
Reposted 3 days ago
Program Manager, Materials Planning
$137K - $185K *
Elevate procurement strategies by analyzing supplier performance and collaborating cross-functionally to ensure material availability and operational efficiency, driving continuous improvement in supp...
Reposted today
Staff/Principal AI Scientist - Virtual Tissue
$150K - $180K *
Engineer advanced protein design models and collaborate with experts to innovate in AI Drug Discovery, driving the development of candidate antibody therapeutics through deep learning and systems biol...
Reposted 1 week ago
Counsel - Commercial Transactions
$132K - $221K *
Drive enterprise-wide legal support for global contracting activities, focusing on procurement and technology transactions. Collaborate with cross-functional teams to manage risks and ensure complianc...
2 weeks ago
Regional Clinical Trial Management Associate
$72K - $97K *
Accelerate progress at clinical trials by supporting regional study delivery, ensuring quality standards, and collaborating with key stakeholders to meet study goals within timelines and budget...
3 weeks ago
Senior Principal, Business Management
$135K - $160K *
Drive strategic initiatives by developing KPI frameworks and operational dashboards, analyzing performance data, and collaborating across teams to enhance business outcomes and support informed decisi...
Today
Senior Product Manager - Fraud
$200K - $250K *
Champion the evolution of fraud prevention strategies, enhancing customer experience while safeguarding against risks. Collaborate cross-functionally to design innovative solutions that balance securi...
Yesterday
Sys SVP Financial Planning and Analysis
$210K - $250K *
Drive strategic financial planning and analysis to optimize resource allocation, support executive decision-making, and enhance operational performance across the organization, ensuring alignment with...
2 weeks ago
Sr. Medical Director, Rheumatology - US Remote
$173K - $320K *
Shape the future of rheumatology by providing strategic medical oversight across clinical trials. Lead the innovation and development of groundbreaking therapies while collaborating with multidiscipli...
Reposted 2 weeks ago
$176K - $230K *
Lead the charge in transforming healthcare through data-driven solutions. As a Senior Data Scientist, you'll spearhead projects that enhance patient outcomes, leveraging your expertise to align data s...
4 weeks ago
Lead Product Manager, Next Best Action Use Case Management
$126K - $173K *
Join a team that's redefining product management by owning the end-to-end strategy for Next Best Action. Collaborate with cross-functional teams to drive discovery, prioritize initiatives, and deliver...
3 days ago
$131K - $151K *
Unlock your potential as a Nurse Practitioner, providing essential primary care to underserved communities. Collaborate with a dedicated team to enhance patient health and deliver quality services in...
4 weeks ago
Manager, Performance Marketing
$105K - $115K *
Join a team that's focused on diversifying paid media channels and optimizing conversion strategies. You'll lead initiatives across affiliate, programmatic, and social platforms to enhance member acqu...
1 week ago
Clinical Consulting Manager, RWD
$110K - $130K *
Drive impactful clinical consulting by bridging expertise in real-world data with strategic insights. Collaborate across teams to enhance health outcomes research and contribute to thought leadership...
2 weeks ago
Staff Bioinformatics Engineer, Clinical Applications
$134K - $179K *
Lead the charge in bridging genomic variants with clinical insights, collaborating with scientists to automate and scale curation workflows. Drive innovation in AI/ML applications while ensuring softw...
1 week ago
$145K - $165K *
Drive impactful clinical research strategies by collaborating with cross-functional teams, analyzing data, and disseminating findings through publications and presentations. Elevate your career while...
Today
$101K - $203K *
Transform product strategy by leading digital product development and enhancements. Collaborate with cross-functional teams to gather insights, prioritize initiatives, and drive innovation that meets...
1 week ago
$85K - $110K *
Develop engaging, platform-native content that connects healthcare insights with audiences. Collaborate with teams to create innovative social media strategies, transforming complex information into r...
Reposted 1 week ago
Customer Care Veterinary Technician
$72K - $104K *
Unlock your potential by delivering exceptional customer support in veterinary care. Engage with clients, resolve inquiries, and ensure compliance with industry standards while collaborating with inte...
1 week ago
$105K - $120K *
Empower healthcare professionals by engaging remotely with cardiologists, nephrologists, and primary care providers. Drive sales and support efforts in open territories while delivering a consistent e...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.