Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$150K - $180K *

Drive operational excellence by leading the S&OP strategy, aligning resources with business goals, and optimizing capacity planning across the network to enhance efficiency and service delivery...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$90K - $110K *

Support patient care by managing complex cases in collaboration with healthcare teams. Utilize critical thinking and clinical skills to assess, diagnose, and treat patients in an outpatient urgent car...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$102K - $130K *

Lead the charge in optimizing patient services through effective team management, strategic collaboration, and continuous improvement initiatives. Drive operational efficiencies while ensuring high-qu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$76K - $90K *

Optimize supply chain insights and capabilities, driving client value through data-driven storytelling and collaboration. Lead initiatives that enhance decision-making and foster partnerships, while m...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $145K *

Join a team that's advancing data analytics for VA modernization initiatives. Utilize SQL and Python to drive AI-enabled insights, enhance operational workflows, and support decision-making through ri...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

$54K - $159K *

Drive your career with impactful leadership in Medicare supplemental benefits. Oversee implementation and operations, ensuring effective program delivery and continuous improvement in a dynamic, colla...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Empower your career by joining a dynamic team as an Epic Prelude Analyst, driving enhancements in patient access and revenue cycle workflows through collaboration and innovative solutions...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Engage in cutting-edge AI development by designing and scaling intelligent applications. Leverage Generative AI and modern tools to enhance productivity and integrate workflows within healthcare platf...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $190K *

Transform the future of enterprise deployment by leading SAP S/4HANA initiatives across multiple regions. Drive strategic alignment, ensure operational readiness, and deliver measurable outcomes while...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$125K - $143K *

Drive the development and execution of tailored training programs, ensuring effective skill enhancement for sales representatives. Collaborate with cross-functional teams to align training strategies...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in managing complex clinical trials, ensuring timely delivery, budget adherence, and high-quality outcomes while collaborating with multidisciplinary teams and stakeholders to enhance...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Contribute to quality operations initiatives by reviewing study documents, supporting audits, and ensuring compliance with regulatory standards. Collaborate with cross-functional teams to enhance qual...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$205K - $380K *

Engage as a strategic leader in enterprise sales, driving growth by securing key healthcare partnerships and executing market strategies. Collaborate with cross-functional teams to enhance customer va...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$156K - $212K *

Shape the future of training by leading impactful learning solutions for obesity and related conditions. Collaborate with cross-functional teams to design and deliver engaging curricula that enhance f...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$55K - $109K *

Engage in leading the dental Provider Relations team, enhancing provider relationships and operational effectiveness. Drive network management activities to ensure member access to care and improve pr...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $160K *

Contribute to the evolution of data-driven healthcare products, shaping strategy and execution. Collaborate with cross-functional teams to deliver AI-enabled solutions that enhance clinical outcomes a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $180K *

Unlock the potential of brand innovation by leading strategy and consumer insights for new product launches. Collaborate across teams to shape compelling narratives and ensure market readiness, drivin...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Innovate the future of architectural strategy by leading technical direction, fostering collaboration across teams, and driving scalable solutions that align with business goals while mentoring senior...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Healthcare

$145K - $218K *

Architect innovative market access strategies to enhance U.S. reimbursement for cutting-edge healthcare solutions. Collaborate across functions to drive payer engagement, coding, and coverage initiati...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$172K - $233K *

Engage with healthcare leaders to advance scientific knowledge and improve patient outcomes in obesity care. Collaborate with internal and external stakeholders, support research initiatives, and ment...

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a dynamic team to support product management for government insurance, ensuring compliance and driving strategic initiatives. Leverage your expertise to lead analysis, define requirements, and en...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $190K *

Drive member activation by leading a cross-functional team to optimize outreach, incentives, and messaging strategies. Own the activation roadmap and funnel metrics to enhance engagement and ensure sc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$94K - $136K *

Transform financial insights into strategic decisions by providing advanced analytical support across Finance, Operations, and Strategic Planning. Collaborate with leadership to drive impactful projec...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Optimize clinical support for Heart Alert Service by reviewing ECG episodes, ensuring accurate documentation, and collaborating across functions to enhance patient care and workflow efficiency...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$90K - $140K *

Transform your career by driving growth and adoption of innovative surgical glaucoma technology. Engage with healthcare professionals, deliver expert support, and build lasting relationships to enhanc...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.