Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Provider Operations Manager - Credentialing
$73K - $115K *
Grow your career with a dynamic team focused on optimizing provider operations. Lead credentialing initiatives, implement AI solutions, and enhance workflows while ensuring compliance and operational...
3 days ago
Medicaid Data & Analytics Specialist
$80K - $95K *
Unlock your potential by analyzing Medicaid data to enhance program performance, quality, and access. Collaborate with diverse teams to develop insights that drive impactful decisions in healthcare an...
2 weeks ago
$225K - $265K *
Shape the future of oncology by leading clinical studies in early-phase development. Collaborate with multidisciplinary teams to drive innovative therapies and ensure high-quality execution of clinica...
Reposted today
Senior Director / Director , Breast Oncology Lifecycle Management
$186K - $233K *
Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...
3 weeks ago
Associate Director, Virtual Health
$115K - $125K *
Drive the development and management of virtual health services, enhancing operational excellence and patient experience while scaling innovative care models across the organization. Lead strategic in...
Yesterday
Senior Copywriter, Promotional Medical Writing
$80K - $100K *
Shape the future of medical communications by crafting high-quality, scientifically accurate content. Collaborate with diverse teams to deliver impactful resources that meet client needs while mentori...
2 days ago
Psychiatric Nurse Practitioner (Synchronous AHPC) - Remote
$171K - $246K *
Shape the future of mental health care by providing remote psychiatric assessments and treatments. Deliver compassionate support to diverse clients, focusing on adults and adolescents, while collabora...
Reposted yesterday
$101K - $126K *
Join a dynamic team to lead complex projects, ensuring timely delivery and alignment with strategic goals. Collaborate across departments, manage risks, and mentor others while leveraging best practic...
2 weeks ago
Director of Product, Logistics
$291K - $307K *
Innovate as you lead the Logistics product organization, shaping strategy and vision for sustainable growth while driving efficiencies that enhance the marketplace experience for customers, shoppers...
Reposted today
Senior Key Account Manager, Pet Food - US Based (Remote)
$110K - $130K *
Unlock your potential by managing key accounts in the pet food industry. Collaborate with diverse brands to drive growth, enhance customer relationships, and execute strategic plans that improve pet h...
1 week ago
Associate Director, Global Revenue, Technical Accounting & Reporting
$177K - $221K *
Champion global revenue accounting policies and lead technical assessments across U.S. and international markets, ensuring compliance with U.S. GAAP and SEC reporting while collaborating with regional...
3 weeks ago
$80K - $95K *
Empower business success by collaborating with cross-functional teams to enhance operations, gather requirements, and implement IT solutions that align with strategic goals. Drive improvements in orde...
2 weeks ago
Senior Clinical Scientist - Oncology - Home Based
$110K - $130K *
Transform your career with a pivotal role in clinical research, leading oncology studies and collaborating with cross-functional teams to ensure scientific excellence and regulatory compliance while m...
1 week ago
Specialist, Clinical Implementations (Clinical Licensure Required) - REMOTE
$80K - $95K *
Innovate clinical system implementations by ensuring seamless integration of technologies and workflows. Collaborate with clinical and technical teams to enhance patient care and operational efficienc...
1 week ago
Digital Technology Product Owner, Medical Affairs
$156K - $214K *
Transform the digital landscape for Medical Affairs by owning product vision, prioritizing backlogs, and ensuring compliance. Collaborate with experts to deliver insights and enhance engagement throug...
4 weeks ago
RVP, Sales - Splunk Federal Civilian
$404K - $500K+*
Transform the Federal Civilian landscape by leading sales teams to drive adoption of cybersecurity and data solutions. Cultivate executive relationships, establish GTM strategies, and achieve multi-mi...
1 week ago
Senior Specialist, Epic Solution Delivery (Ambulatory)
$110K - $130K *
Lead the charge in Epic solutions delivery by providing expert support, managing projects, and mentoring team members. Shape the future of healthcare IT by aligning technical teams with stakeholder ne...
Reposted today
$110K - $130K *
Empower your career by leading sales strategies across the US. Collaborate with a dynamic team to drive growth, develop client relationships, and deliver impactful presentations while navigating indus...
1 week ago
Principal HL7 Integration Engineer
$110K - $140K *
Shape the future of healthcare integration by leading and executing complex HL7 projects. Utilize your expertise in medical informatics and enhancing customer satisfaction while managing dynamic, mult...
Reposted 2 days ago
Triage Clinical Guide (Registered Nurse) – Night Shift
$95K - $110K *
Partner with us to transform healthcare delivery by providing telephonic clinical triage and support. You'll advocate for members, ensuring they receive timely care while collaborating with a dedicate...
Yesterday
Assistant Director, Global Service Delivery
$100K - $120K *
Advance global service delivery by managing offshore partnerships, ensuring performance excellence, and driving operational improvements across teams to enhance productivity and quality outcomes...
Reposted today
$101K - $154K *
Shape product strategy and commercialization efforts, ensuring alignment with market trends and customer needs. Drive product development, marketing initiatives, and cross-functional collaboration to...
1 week ago
$90K - $105K *
Advance your career by leading a dedicated team in delivering trauma-informed care for substance use disorders. Shape clinical practices and foster a supportive environment in a new clinic focused on...
Reposted 1 week ago
Hematology Therapeutic Specialist (South Texas)
$110K - $130K *
Champion the growth of hematology products by educating healthcare providers, driving demand, and fostering relationships within cancer centers. Leverage cross-functional teams to ensure a positive ex...
1 week ago
$187K - $257K *
Empower transformation initiatives by leading enterprise projects, managing stakeholder relationships, and driving strategic outcomes. Collaborate with diverse teams to define program strategies and e...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.