Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Product Manager, Value realization
$104K - $143K *
Deliver impactful reporting solutions by translating measurement needs into actionable requirements, managing backlogs, and collaborating with cross-functional teams to ensure effective execution and...
3 days ago
Principal Product Manager, Member Experience
$200K - $230K *
Champion a transformative member software experience, guiding strategy and design across the care journey. Leverage data and user insights to drive impactful solutions in a complex healthcare landscap...
2 weeks ago
$130K - $160K *
Drive growth as an integral part of our Commercial Sales Team, managing key health system relationships and closing complex deals, while collaborating across departments and shaping the product roadma...
1 month ago
Senior Operations Manager, Quality Control
$104K - $145K *
Lead the charge in developing a robust quality control program, managing a team to enhance operational processes, mitigate risks, and ensure compliance across lending operations while leveraging autom...
1 week ago
Lab Point of Care Sales Specialist
$100K - $115K *
Unlock potential by providing vital sales support and presentations, driving customer integration and product utilization, while conducting market research to enhance offerings. Collaborate closely wi...
Reposted 1 week ago
Senior Data Scientist, Marketing Measurement, Consumer Solutions
$115K - $130K *
Drive marketing measurement innovation by developing scalable frameworks and advanced analytics. Collaborate across teams to enhance performance tracking, optimize investment strategies, and deliver a...
Today
$102K - $154K *
Advance customer success by managing complex escalations, driving cross-functional improvements, and enhancing workflows. Lead high-severity issue resolution while fostering a structured, customer-cen...
4 weeks ago
Hospital Inpatient Coding Manager
$77K - $121K *
Join a team that's redefining coding excellence by leading operational strategies, managing staff performance, and ensuring compliance in inpatient coding processes to enhance efficiency and quality a...
1 week ago
$80K *
Empower clients by managing complex care needs through remote case management, ensuring access to high-quality treatment and support. Collaborate with multidisciplinary teams to enhance client engagem...
2 weeks ago
Behavioral Health Medical Director
$223K - $313K *
Shape the future of behavioral health care strategy and operations. Leverage your medical expertise to enhance quality, operational efficiency, and patient outcomes while navigating complex regulatory...
Reposted yesterday
Provider Operations Manager - Credentialing
$73K - $115K *
Grow your career with a dynamic team focused on optimizing provider operations. Lead credentialing initiatives, implement AI solutions, and enhance workflows while ensuring compliance and operational...
3 days ago
Medicaid Data & Analytics Specialist
$80K - $95K *
Unlock your potential by analyzing Medicaid data to enhance program performance, quality, and access. Collaborate with diverse teams to develop insights that drive impactful decisions in healthcare an...
2 weeks ago
$225K - $265K *
Shape the future of oncology by leading clinical studies in early-phase development. Collaborate with multidisciplinary teams to drive innovative therapies and ensure high-quality execution of clinica...
Reposted today
Senior Director / Director , Breast Oncology Lifecycle Management
$186K - $233K *
Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...
3 weeks ago
Associate Director, Virtual Health
$115K - $125K *
Drive the development and management of virtual health services, enhancing operational excellence and patient experience while scaling innovative care models across the organization. Lead strategic in...
Yesterday
Senior Copywriter, Promotional Medical Writing
$80K - $100K *
Shape the future of medical communications by crafting high-quality, scientifically accurate content. Collaborate with diverse teams to deliver impactful resources that meet client needs while mentori...
2 days ago
Psychiatric Nurse Practitioner (Synchronous AHPC) - Remote
$171K - $246K *
Shape the future of mental health care by providing remote psychiatric assessments and treatments. Deliver compassionate support to diverse clients, focusing on adults and adolescents, while collabora...
Reposted yesterday
$101K - $126K *
Join a dynamic team to lead complex projects, ensuring timely delivery and alignment with strategic goals. Collaborate across departments, manage risks, and mentor others while leveraging best practic...
2 weeks ago
Senior Key Account Manager, Pet Food - US Based (Remote)
$110K - $130K *
Unlock your potential by managing key accounts in the pet food industry. Collaborate with diverse brands to drive growth, enhance customer relationships, and execute strategic plans that improve pet h...
1 week ago
Associate Director, Global Revenue, Technical Accounting & Reporting
$177K - $221K *
Champion global revenue accounting policies and lead technical assessments across U.S. and international markets, ensuring compliance with U.S. GAAP and SEC reporting while collaborating with regional...
3 weeks ago
$80K - $95K *
Empower business success by collaborating with cross-functional teams to enhance operations, gather requirements, and implement IT solutions that align with strategic goals. Drive improvements in orde...
2 weeks ago
Senior Clinical Scientist - Oncology - Home Based
$110K - $130K *
Transform your career with a pivotal role in clinical research, leading oncology studies and collaborating with cross-functional teams to ensure scientific excellence and regulatory compliance while m...
1 week ago
Specialist, Clinical Implementations (Clinical Licensure Required) - REMOTE
$80K - $95K *
Innovate clinical system implementations by ensuring seamless integration of technologies and workflows. Collaborate with clinical and technical teams to enhance patient care and operational efficienc...
1 week ago
Digital Technology Product Owner, Medical Affairs
$156K - $214K *
Transform the digital landscape for Medical Affairs by owning product vision, prioritizing backlogs, and ensuring compliance. Collaborate with experts to deliver insights and enhance engagement throug...
4 weeks ago
RVP, Sales - Splunk Federal Civilian
$404K - $500K+*
Transform the Federal Civilian landscape by leading sales teams to drive adoption of cybersecurity and data solutions. Cultivate executive relationships, establish GTM strategies, and achieve multi-mi...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.