Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$200K - $230K *
Join a team that's shaping the future of migraine treatment by leading U.S. marketing strategies. Drive brand awareness and engagement through innovative campaigns, collaborating across functions to e...
3 weeks ago
21GRAMS- Senior Delivery Manager
$95K - $100K *
Join our dynamic team as a Technical Delivery Manager, overseeing AI-driven project delivery across diverse digital platforms. Ensure timely, high-quality outputs while leveraging innovative technolog...
1 week ago
ED, Advanced Analytics and Modeling
$225K - $418K *
Elevate your career by leading advanced analytics initiatives that drive strategic business decisions and measurable impact. Collaborate with global teams to innovate and implement cutting-edge analyt...
Today
Professional (Senior) Sales Representative, Respiratory – Cape Coral, FL
$100K - $162K *
Engage with healthcare professionals to drive sales growth in the Cape Coral territory. Develop strategic business plans, conduct impactful presentations, and foster strong relationships while adherin...
2 days ago
Account Executive (Oncology) Philly
$63K - $112K *
Join a team that's dedicated to enhancing client relationships and driving sales growth through effective product presentations and customer feedback. Collaborate with marketing and sales staff to ens...
1 week ago
Project Director, Dermatology and Rheumatology, CRO, US, remote USA
$125K - $150K *
Oversee a portfolio of clinical studies, ensuring compliance and quality. Lead Project Managers in executing complex trials, driving operational efficiency and client satisfaction while leveraging you...
2 weeks ago
Director of Reimbursement & Regulatory Analysis
$125K - $150K *
Optimize reimbursement strategies and regulatory compliance by leading analysis, developing policies, and mentoring teams. Drive operational excellence and foster relationships with stakeholders to en...
Today
$124K - $206K *
Drive the end-to-end revenue marketing strategy to enhance pipeline growth, accelerate revenue, and strengthen market positioning. Lead a cross-functional team to optimize performance and scale impact...
2 weeks ago
$90K - $110K *
Transform Medicaid programs by managing initiatives, coordinating stakeholders, and driving quality improvements. Leverage your expertise to implement policies and enhance operational efficiency in a...
2 weeks ago
$105K - $115K *
Optimize medical device utilization in health systems by leveraging expertise in cardiovascular, interventional radiology, and general surgery. Collaborate with stakeholders to drive cost reduction an...
2 weeks ago
Director, Access Strategy & Marketing
$201K - $251K *
Elevate access strategies and marketing initiatives for oncology products, focusing on non-clinical value propositions. Collaborate cross-functionally to ensure successful product launches and effecti...
3 days ago
Senior Bioinformatics Scientist
$117K - $146K *
Lead the charge in developing innovative algorithms and pipelines for early cancer detection, collaborating with cross-functional teams to analyze complex genomic datasets and enhance clinical diagnos...
Yesterday
$71K - $118K *
Engage in advanced nuclear imaging procedures, ensuring patient safety and quality care. Collaborate with a skilled team using state-of-the-art technology to deliver diagnostic and therapeutic service...
Reposted 2 weeks ago
Principal Health Data Scientist
$130K - $155K *
Lead advanced analytics and statistical modeling to transform complex healthcare data into actionable insights, collaborating with cross-functional teams to solve strategic business challenges and enh...
Today
$160K - $200K *
Shape the future of product strategy by leading a high-performing team, driving innovation, and ensuring alignment across operations and technology to deliver exceptional customer value and measurable...
2 weeks ago
Associate/Sr. Associate, Academic Partnering, Asset Acquisition
$130K - $150K *
Advance innovative therapeutic programs targeting genetically driven diseases through strategic sourcing, relationship building, and cross-functional collaboration, ensuring a patient-first approach i...
Yesterday
$110K - $140K *
Pioneer GxP compliance in digital quality management, ensuring software and AI products meet regulatory standards. Collaborate with stakeholders to enhance quality processes and support audits, drivin...
2 weeks ago
$108K - $130K *
Drive program delivery across multiple products, ensuring timely outcomes by managing risks, dependencies, and stakeholder priorities. Collaborate cross-functionally to maintain accurate project data...
3 weeks ago
Senior Medical Science Liaison, Central (Multiple Territories)
$190K - $220K *
Champion impactful scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and driving prelaunch strategies in a dynamic environment...
1 week ago
$72K - $120K *
Lead a multi-disciplinary team in developing machine learning algorithms to enhance clinical decision support, leveraging healthcare datasets for innovation and making vital discoveries that drive pro...
Reposted 3 weeks ago
Medical Affairs and Evidence Generation Asset Lead – Executive Director
$325K - $447K *
Elevate medical affairs by providing strategic insights for clinical asset development and commercialization. Lead cross-functional teams, execute evidence generation plans, and foster collaboration t...
Reposted 1 week ago
$120K - $150K *
Champion demand generation by executing integrated campaigns to drive pipeline growth and revenue, collaborating cross-functionally with Sales and Product teams for fuel growth through strategic marke...
Reposted 4 weeks ago
$80K - $95K *
Champion excellence in rehabilitation services by leading a dedicated team, ensuring compliance with regulations, and enhancing patient care while achieving financial goals and fostering collaboration...
2 weeks ago
Senior Regulatory Affairs Specialist (Remote - United States)
$124K - $170K *
Champion regulatory strategies to accelerate product approvals and compliance. Lead a dynamic team in supporting innovative medical devices, ensuring alignment with global regulations while fostering...
1 week ago
21GRAMS- Associate Creative Director, Art
$160K - $180K *
Elevate healthcare creativity by leading innovative campaigns that transform client brands. Collaborate with teams to deliver impactful experiences across digital channels, leveraging insights and eme...
3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.