Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$250K - $300K *

Oversee and deliver exceptional diagnostic imaging services remotely, focusing on evening shifts. Collaborate within a dynamic team while managing varied inpatient and outpatient cases to support pati...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$71K - $118K *

Accelerate progress at client relationships by driving sales growth, consulting on laboratory services, and exceeding targets to enhance patient care. Collaborate effectively with stakeholders while m...

RemoteRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Healthcare

$220K - $255K *

Shape the future of healthcare by leading strategic payor relationships and driving reimbursement strategies. Collaborate cross-functionally to enhance patient access and optimize coverage for innovat...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Help us drive business development in oncology by leading strategic partnerships and optimizing resources to enhance clinical outcomes and market potential for our innovative diagnostic and therapeuti...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Champion the development and oversight of scientific content across diverse therapeutic areas while managing client relationships and brand strategy for multiple accounts, ensuring high-quality and im...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$95K - $115K *

Optimize supply planning for finished goods, driving process improvements and inventory management while collaborating with cross-functional teams to meet sales and operational goals...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $90K *

Transform client objectives into impactful paid social strategies. Oversee campaign execution, optimize performance, and mentor junior team members while driving cross-functional collaboration to achi...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$235K - $270K *

Join a dynamic team to lead transformative improvements in global supply chain operations, focusing on logistics excellence and strategic initiatives that enhance service, cost efficiency, and operati...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Join our team to drive sales across a defined portfolio, engaging healthcare organizations with our innovative solutions. Own the sales cycle from prospecting to closing while collaborating with inter...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$138K - $188K *

Lead global trade compliance initiatives, ensuring adherence to regulations across multiple jurisdictions. Drive strategic programs for import/export operations, risk management, and partner governanc...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Shape the future of corporate law by providing strategic legal counsel on M&A, governance, and compliance for a dynamic multinational company. Collaborate with diverse teams to navigate complex transa...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$158K - $197K *

Unlock potential by leading the automation of clinical data integration and dashboard development. Collaborate across teams to enhance data usability and implement AI solutions, ensuring compliance an...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Lead regional sales initiatives, driving product launch success and team performance. Collaborate cross-functionally to execute strategies, foster customer relationships, and ensure compliance while b...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$157K - $213K *

Lead a dynamic team to develop innovative training for oncology sales, aligning with business priorities and enhancing team capabilities in a fast-paced environment. Collaborate with stakeholders to e...

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $181K *

Shape the future of nursing education by leading curriculum development, faculty empowerment, and student success initiatives. Drive compliance and foster collaboration to enhance academic operations...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$195K - $264K *

Champion growth by leading a team of Pulmonology Medical Specialists, driving sales performance, and fostering talent development while ensuring compliance and integrity in a dynamic market environmen...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Analyze performance metrics to empower ACOs in Value-Based Care programs. Collaborate with teams to provide actionable insights, track KPIs, and optimize risk scores, driving data-driven decisions for...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$194K - $361K *

Lead the development of innovative NovaOS capabilities, ensuring alignment with business goals and driving continuous improvement through collaboration across cross-functional teams. Deliver measurabl...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$116K - $145K *

Optimize proposal performance and strategic growth initiatives, leading a collaborative team to enhance RFP responses, competitive positioning, and resource allocation for maximum impact and success a...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Advance supply chain efficiency by overseeing sourcing, logistics, and inventory management. Collaborate across teams to optimize production schedules and drive continuous improvement, ensuring timely...

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$76K - $90K *

Transform compliance by managing DOT trucking programs, ensuring safety and regulatory adherence across operations. Collaborate with teams to develop effective EHS initiatives and maintain high standa...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $250K *

Accelerate progress at our rapidly growing segment by leading sales efforts into child welfare and behavioral health markets. Build relationships, drive pipeline development, and execute sales strateg...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$140K - $185K *

Accelerate progress at the forefront of payor relations, leading a team to develop strategic partnerships that enhance patient access and optimize reimbursement for innovative medical technologies in...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Unlock potential by leading Health and VA claims operations, driving strategic initiatives, enhancing recovery outcomes, and ensuring operational excellence across multiple teams and client portfolios...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$134K - $162K *

Contribute to the advancement of medical physics by leading dosimetry analysis for radiopharmaceuticals. Collaborate with cross-functional teams to drive research in drug development and improve imagi...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.