Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$126K - $234K *

Unlock potential by designing and delivering innovative training solutions for customer-facing teams, enhancing product knowledge and engagement skills across diverse therapeutic areas and roles...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$200K - $250K *

Drive critical initiatives by navigating ambiguity, building effective operating models, and ensuring measurable outcomes in a dynamic environment. Engage with leadership to implement AI solutions and...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $120K *

Grow your career with a dynamic sales role, driving supply chain transparency for leading brands. Own the full sales cycle, engage senior stakeholders, and develop solutions that enhance customer valu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$190K - $220K *

Champion scientific engagement by building relationships with key stakeholders, translating clinical data into actionable insights, and driving prelaunch strategies in a dynamic environment. Operate i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$254K - $382K *

Pioneer innovative clinical strategies as a senior medical leader, driving excellence in study execution and client engagement. Collaborate with cross-functional teams to enhance patient care and oper...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Champion new business opportunities in the diagnostic sales sector, driving growth in non-acute care markets. Achieve sales quotas, foster client relationships, and implement innovative technologies t...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$200K - $220K *

Join a team that's redefining strategic sourcing for commercial categories. Lead initiatives that drive value, enhance supplier performance, and align with business goals while managing vendor relatio...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$223K - $313K *

Collaborate with a dedicated team of physicians to ensure high-quality inpatient care through clinical expertise, thorough reviews, and utilization management. Advance patient outcomes by utilizing st...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$164K - $305K *

Lead the charge in developing strategic relationships with C-suite executives to drive growth, retention, and value realization across complex health systems, ensuring integrated solutions and measura...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Elevate your career by leading strategic IT solutions and driving software asset management excellence. Collaborate with stakeholders, mentor peers, and influence outcomes through innovative analysis...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Shape the future of women's health by providing comprehensive midwifery care across inpatient and outpatient settings. Collaborate with a multidisciplinary team to support mothers and newborns through...

Today

  •   Less than 5 years exp.  •   Healthcare

$85K - $117K *

Join a team that's redefining clinical diagnostics by expanding our plasma protein portfolio. Drive new equipment placements and enhance assay utilization across a diverse territory while fostering st...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join us in shaping the future of maternal and newborn health by leading innovative strategies in commodity financing and procurement. Drive impactful change at global and country levels to ensure esse...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Optimize patient care by leading the rehabilitation department, ensuring compliance and financial performance while fostering teamwork and excellence in service delivery across multiple sites...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Serve as the primary contact for clients, driving engagement and service quality while fostering relationships with key stakeholders and leveraging expertise to enhance organizational growth and clien...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$119K - $190K *

Champion ABB's growth in the Pharmaceutical & Biotechnology sector by developing strategies, building executive relationships, and identifying market opportunities to drive sales and enhance customer...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$152K - $283K *

Deliver impactful field execution by bridging strategy and operations, ensuring initiatives achieve success through proactive risk management and collaboration across teams, all while enhancing accoun...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Tackle data-driven decisions as a senior product analyst, owning A/B testing design and analysis while collaborating across teams to enhance user experience and drive growth through insightful experim...

RemoteRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$144K - $288K *

Pioneer innovative digital product strategies to enhance quality measures and performance in healthcare. Collaborate with multidisciplinary teams to optimize technology pathways, ensuring exceptional...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$210K - $331K *

Empower your career by leading a dynamic team of medical professionals, driving strategic initiatives, and ensuring compliance in a fast-paced environment. Collaborate on impactful projects while fost...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$152K - $190K *

Drive the future of data analytics by leading a dynamic team to enhance enterprise data strategies, governance, and insights that align with business objectives and foster innovation across the organi...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$210K - $250K *

Join a dedicated team providing comprehensive medical care and education to patients. Assess, diagnose, and treat with a focus on quality and safety, while collaborating with healthcare professionals...

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$60K - $132K *

Elevate provider networks by managing complex contracts, enhancing compliance, and driving financial goals. Collaborate cross-functionally to optimize recruitment and negotiations, ensuring quality an...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$61K - $129K *

Lead legal research and support for AUSAs, analyzing complex cases and drafting documents. Collaborate with attorneys to ensure compliance with laws and procedures while managing habeas corpus and imm...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$245K - $265K *

Build impactful partnerships with Medical Experts to enhance neurology care. Drive strategic insights and collaboration across teams, influencing marketing and education initiatives while engaging wit...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.