Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$100K - $120K *
Help us transform eye care for Veterans by providing comprehensive optometric services. As a key member of our team, you'll independently manage patient care, perform essential testing, and contribute...
Today
Associate Director, Client Media Solutions
$95K - $120K *
Accelerate progress at the intersection of media and healthcare by leading integrated planning and strategy for pharmaceutical clients. Drive impactful engagement initiatives while mentoring a talente...
1 week ago
Account Specialists (La Crosse, WI)
$160K - $192K *
Join a team that's driving commercial success by engaging healthcare providers, building relationships, and supporting innovative therapies. Your expertise will be crucial in executing business plans...
1 week ago
SA39P3 Sales Tech Product Consultant
$85K - $100K *
Elevate customer engagement by providing expert technical training and consulting. Collaborate with sales teams to enhance product understanding and drive growth through tailored demonstrations and su...
1 week ago
Sr Manager, Data Process Excellence & Transformation
$115K - $192K *
Elevate operational excellence by leading process design and transformation initiatives. Drive automation, quality management, and continuous improvement to enhance client data operations and ensure s...
Reposted 3 days ago
Regional Sales Director - Upstate NY
$180K - $215K *
Join us to lead regional sales efforts, driving product launch success and team performance. You'll build strong customer relationships, execute strategic plans, and foster a high-performing culture i...
1 week ago
$141K - $196K *
Unlock potential by developing causal machine-learning models to optimize customer offers, analyzing complex data, and translating findings into actionable strategies for enhanced conversion rates acr...
Today
Director, Managed Markets - Regional - Northeast
$235K - $270K *
Join a team that's driving access strategy across the Northeast, managing key payer relationships and ensuring launch readiness for rare disease therapies. Collaborate with cross-functional teams to o...
2 days ago
VP, Market Access and Strategice Engagement
$210K - $250K *
Shape the future of patient access by leading integrated strategies that enhance customer engagement and optimize portfolio performance across diverse healthcare channels, driving sustainable growth a...
1 week ago
Senior Director, Employer Program Management (P5), Lilly Employer
$166K - $244K *
Join a dynamic team to lead the Employer PMO, driving strategic program delivery and cross-functional alignment while enhancing operational efficiency and leveraging modern tools for impactful outcome...
2 days ago
Senior Director, Global ERP Delivery & Solution Architecture
$151K - $314K *
Shape the future of global ERP delivery by leading a diverse team, executing strategic initiatives, and driving transformation across multiple regions to enhance operational efficiency and business va...
2 weeks ago
Regional Sales Director - Nashville
$180K - $215K *
Transform your career by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster strong cus...
1 week ago
Dir, Thought Leader Liaison (Oncology)
$203K - $245K *
Unlock potential by leading a national team of Thought Leader Liaisons to enhance KOL engagement and advocacy in oncology. Drive strategic initiatives, foster collaboration, and ensure compliance whil...
Reposted 2 days ago
$93K - $104K *
Unlock potential by joining our team of dedicated Registered Nurses, providing essential care in diverse settings. Enjoy flexible scheduling, competitive pay, and the opportunity to make a meaningful...
Today
$93K - $104K *
Join a team that's dedicated to providing exceptional patient care while enjoying flexible scheduling options. As a Registered Nurse, you'll play a vital role in assessing and supporting patients in v...
Today
Head of Business Development, Pharma/Life Sciences
$200K *
Transform the landscape of life sciences partnerships by driving co-developed deals. Leverage your extensive network and expertise to source, pitch, and close high-value agreements that enhance patien...
Today
Associate Director, Biostatistics & AI
$173K - $217K *
Unlock potential by driving high-quality statistical analyses and AI integration in the pharmaceutical sector. Collaborate across functions to enhance drug development and regulatory processes through...
Reposted 3 weeks ago
Clinical Science Liaison (CSL)
$150K - $180K *
Innovate healthcare delivery by serving as a clinical liaison, translating partner needs into actionable insights for chronic care and telehealth programs, impacting thousands of patients nationwide t...
3 weeks ago
Value & Access Insights, Manager
$124K - $169K *
Drive strategic insights and analytics to enhance payer access and pricing strategies for biopharmaceutical products, ensuring optimal patient access in a complex healthcare landscape. Collaborate acr...
Yesterday
Senior Project Manager (Neuroscience)
$122K *
Elevate your career by managing global projects in Neuroscience, ensuring compliance, budget adherence, and successful collaboration across cross-functional teams to drive milestone achievement and en...
Reposted 3 weeks ago
$210K - $250K *
Contribute to a patient-focused care environment by managing evaluations, diagnoses, and treatments. Collaborate within a multidisciplinary team to promote health education and ensure quality care ali...
Reposted yesterday
Business Insights Analyst, Remote US
$80K - $95K *
Grow your career with a dynamic role that drives actionable insights across e-commerce and service delivery. Collaborate with stakeholders to analyze data, build impactful reports, and enhance busines...
1 week ago
Senior Oncology Account Manager, Omaha
$155K - $232K *
Manage strategic oncology accounts by promoting products, building relationships, and implementing marketing strategies to achieve sales goals. Collaborate with cross-functional teams to address custo...
1 week ago
Trial Delivery Management (Advanced)
$110K - $130K *
Lead the charge in managing complex projects within the pharmaceutical and biotech sectors, ensuring successful execution and delivery while mentoring teams and collaborating with stakeholders to achi...
1 week ago
Manager, Value & Access Analytics - GTN Forensics - U.S. Remote
$124K - $169K *
Optimize cross-portfolio analytics to enhance Gross-to-Net performance, identify anomalies, and drive process improvements. Collaborate with diverse teams to deliver actionable insights and scalable r...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.