Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Director, Biostatistics
$295K - $314K *
Drive strategic biostatistical leadership for clinical development programs, overseeing statistical activities, collaborating with cross-functional teams, and ensuring high-quality data analysis to su...
3 weeks ago
Executive Director, Technology
$175K - $215K *
Elevate the technology function by leading engineering, delivery, and operations. Collaborate closely with leadership to shape technical strategy, ship code weekly, and ensure high standards in a dyna...
2 weeks ago
Product and Regulatory Counsel
$170K - $190K *
Empower innovation at the intersection of technology and law. Guide product, engineering, and compliance teams in navigating regulatory landscapes and mitigating risks related to AI and machine learni...
Reposted 1 week ago
Senior Oncology Account Manager, Des Moines
$150K - $230K *
Champion the promotion of oncology products, building strong relationships with healthcare professionals to enhance patient access and drive brand value in a competitive market. Lead strategic initiat...
1 week ago
Director, Managed Markets - Regional - Central
$235K - $270K *
Drive your career forward by leading access strategies across the Central region. Manage key payer relationships and ensure launch readiness for rare disease products while collaborating with cross-fu...
2 weeks ago
$210K - $250K *
Drive transformative healthcare initiatives by leading a team of practitioners, optimizing clinical protocols, and enhancing patient care through innovative medical solutions in weight management and...
1 week ago
Operating Effectiveness Principal - Remote - Fertility and Specialty Pharmacy
$130K - $217K *
Join a team that's driving innovation in pharmacy operations, managing complex initiatives, and enhancing business performance. Collaborate with senior leaders to deliver measurable impact and shape t...
Today
Senior Scientific Director - Publications (Oncology)
$150K - $180K *
Drive impactful scientific communication by overseeing content development across therapeutic areas, ensuring strategic alignment with client goals while managing a team and collaborating with various...
4 weeks ago
Specialty Sales Representative - Miami to Fort Myers
$120K - $160K *
Drive brand awareness and product adoption by engaging healthcare professionals and stakeholders. Execute territory strategies, build relationships, and navigate access dynamics to establish trust and...
1 week ago
Associate Director, Clinical Operations
$130K - $160K *
Oversee the operational planning and execution of clinical trials, ensuring compliance with regulatory standards while managing cross-functional teams to meet project timelines, budgets, and quality o...
2 weeks ago
$140K - $175K *
Empower scientific innovation by collaborating within product pods to develop and evaluate real-world evidence agents. Drive impactful research and ensure scientific rigor while partnering with indust...
1 week ago
Director, Field Reimbursement - East
$225K - $250K *
Take ownership of strategic access and reimbursement initiatives, leading a team to navigate complex payer environments. Collaborate cross-functionally to enhance provider education and ensure complia...
Yesterday
Senior Manager, Global Site Start-Up Lead
$134K - $219K *
Unlock potential by leading global site start-up strategies for complex clinical trials. Drive operational excellence, ensure compliance, and collaborate with cross-functional teams to accelerate stud...
Reposted 2 weeks ago
Clinical Study Physician - Oncology - FSP
$160K - $200K *
Lead the charge in medical oversight for clinical trials, ensuring high standards and executing timelines. Collaborate with cross-functional teams to enhance trial protocols and contribute to impactfu...
Reposted 2 days ago
$90K - $103K *
Develop and optimize health and welfare plans, ensuring compliance and efficient administration. Collaborate with TPAs, oversee claims performance, and enhance employee engagement through effective co...
1 month ago
Senior Director, Delivery Excellence
$207K - $277K *
Lead the charge in enhancing global ERP delivery excellence, driving governance, quality, and continuous improvement across teams. Foster collaboration and optimize resource utilization to ensure pred...
3 weeks ago
$80K - $95K *
The Data Integration Specialist at Timely will ensure seamless integration of data between school district systems and Timely's scheduling technology. This role involves collaborating with various sta...
Reposted 4 weeks ago
Senior Manager, Digital Clinical Operations
$136K - $181K *
Drive innovation by optimizing Clinical Operations through digital solutions, enhancing productivity across clinical trial phases while ensuring stakeholder collaboration and strategic alignment with...
Reposted today
Associate Director, Marketing, Lung Patient
$186K - $233K *
Shape impactful marketing strategies for lung cancer programs, collaborating with cross-functional teams to drive patient engagement and launch readiness. Lead initiatives that align with brand goals...
2 days ago
Senior Regulatory Affairs Specialist
$83K - $103K *
Drive success in regulatory affairs by preparing critical submissions for medical and diagnostic devices. Oversee compliance with U.S. and international regulations while collaborating with cross-func...
Reposted 1 week ago
Manufacturing Rotational Program Associate - Chemours Leadership LAB (Early Career)
$73K - $115K *
Launch your engineering career by tackling real manufacturing challenges. Engage in a three-year rotational program that fosters growth through mentorship, diverse experiences, and exposure to industr...
Today
$101K - $197K *
Empower your career by leading global regulatory strategies for medical devices and diagnostics. Collaborate with cross-functional teams to ensure compliance and drive market access while mentoring ot...
3 weeks ago
$80K - $95K *
Join us to independently manage field service activities, ensuring the reliability and performance of life-saving medical devices. This role requires significant travel and offers the opportunity to m...
3 weeks ago
$80K - $95K *
Champion the installation, maintenance, and repair of life-saving medical devices. Manage service activities independently within a designated region, ensuring compliance and customer satisfaction thr...
3 weeks ago
Drug Discovery Resource Outsourcing Manager
$110K - $130K *
Engage in early-stage drug discovery by triaging research requests, managing CRO partnerships, and ensuring seamless execution of outsourced projects. Leverage scientific expertise and Mandarin fluenc...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.