Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Manager, Patient Services Promotions
$138K - $183K *
Lead the development and execution of patient support strategies to enhance access and engagement for oncology therapies, collaborating cross-functionally to optimize promotional initiatives and drive...
1 week ago
$132K - $153K *
Join a team that's redefining care management by leading strategic initiatives in utilization and appeals processes. Drive high-quality, cost-effective care while ensuring compliance and fostering a c...
6 days ago
Director, Market Access Payer Accounts - Northeast
$197K - $246K *
Lead strategic initiatives in market access by managing key payer accounts, ensuring optimal coverage and reimbursement for products. Collaborate with cross-functional teams to enhance patient access...
1 week ago
Staff Graphic Designer, Print & Packaging
$95K - $115K *
Elevate your career by leading innovative packaging design strategies that resonate globally. Collaborate with cross-functional teams to create compelling visuals while ensuring brand consistency and...
2 weeks ago
Senior Oncology Account Manager, Chicago North
$150K - $230K *
Join a team that's transforming oncology care by promoting innovative treatments and building strong relationships with healthcare professionals. Drive brand value and ensure patient access while lead...
1 week ago
$100K - $140K *
Reimagine client success by managing relationships and ensuring seamless communication across teams. Drive operational excellence and enhance client satisfaction through proactive updates, coordinatio...
1 week ago
$80K - $95K *
Join a team that's redefining healthcare recruiting by building and scaling a high-impact Direct Employer business through innovative sales strategies and cutting-edge technology, driving growth direc...
Reposted 4 weeks ago
Senior Director, Head of R&D Governance and Portfolio Management
$228K - $342K *
Advance the future of R&D governance and portfolio management by leading strategic decision-making processes, optimizing operational efficiency, and ensuring seamless progression of therapeutic assets...
Today
Regional Sales Director - Northwest
$180K - $215K *
Unlock regional growth by leading a high-performing sales team, executing launch strategies, and fostering key customer relationships in a dynamic, fast-paced environment. Drive performance and ensure...
1 week ago
Medical Writer, Medical Communications
$80K - $110K *
Join a team that's dedicated to transforming complex scientific data into clear, impactful content. Collaborate with peers to ensure accuracy and adherence to guidelines while developing crucial mater...
Reposted 2 weeks ago
$160K - $200K *
Transform the communications landscape by building a dynamic team that drives brand relevance through strategic earned media, influencer relations, and corporate communications, ensuring a consumer-fi...
3 weeks ago
Account Manager- Client Success
$80K - $85K *
Grow your career with a dynamic team focused on client success, managing relationships, and delivering tailored solutions. Drive satisfaction and retention while collaborating across departments to en...
1 week ago
Senior Manager, Clinical Conduct
$90K - $110K *
Empower cross-functional teams to drive the Future of Medicine initiatives, ensuring scalable processes and compliance while enhancing patient safety and experience through strategic planning and exec...
1 week ago
HIM Outpatient Coding Supervisor
$68K - $113K *
Lead the charge in optimizing coding accuracy and compliance by analyzing complex patient care documentation, providing expert guidance, and enhancing coder education to ensure adherence to ethical st...
3 weeks ago
Executive Director, Strategic Accounts
$246K - $332K *
Transform healthcare by leading national strategic account management efforts. Drive partnerships with key institutions, enhance patient care, and foster cross-functional collaboration to achieve comm...
1 week ago
Regulatory Submissions Lead II
$110K - $130K *
Lead and execute regulatory strategies for multi-region clinical trials, ensuring compliance and timely submissions. Collaborate with project teams to manage risks and drive operational excellence thr...
4 days ago
Senior Director, Clinical Diagnostics and Precision Medicine
$242K - $403K *
Lead global companion diagnostics strategy, integrating diagnostic plans with clinical development and regulatory objectives. Drive execution across therapeutic programs, ensuring alignment with patie...
2 weeks ago
Senior Manager, Clinical Trial Disclosure & Transparency
$132K - $199K *
Join a team that's committed to transparency in clinical trials, ensuring compliance with global disclosure regulations. This role blends operational and strategic tasks, fostering collaboration and q...
2 weeks ago
Account Specialist (Jackson, MS)
$160K - $192K *
Join us to drive commercial performance by engaging healthcare providers, building relationships, and supporting product launches. Your expertise will enhance patient access to innovative therapies an...
1 week ago
Executive Director, HEOR Modeling
$175K - $210K *
Unlock potential by leading HEOR strategy and AI integration, ensuring project success and client satisfaction. Drive business growth, mentor teams, and influence health policy through innovative rese...
Yesterday
Cardiovascular Account Specialist - U.S. Sales, Harrisburg, PA
$162K - $195K *
Drive sales performance by launching a novel cardiac myosin inhibitor, building strategic relationships with healthcare providers, and delivering impactful solutions to meet patient needs in your terr...
Yesterday
$275K - $350K *
Lead the charge in transforming operations by integrating AI and technology to enhance member and clinician experiences, ensuring efficient care delivery and operational excellence across a distribute...
1 week ago
Senior Accountant, Primary Care
$78K - $107K *
Drive financial integrity by managing complex accounting tasks, preparing reports, and influencing departmental strategy. Collaborate with teams to ensure compliance and accuracy while providing valua...
Reposted today
$87K - $157K *
Unlock compliance excellence by managing auditing, monitoring, and reporting processes to ensure adherence to regulatory standards and enhance operational efficiency across contracts and collaboration...
1 month ago
Senior Director Customer Analytics & Insights EMD
$232K - $348K *
Elevate customer understanding by leading analytics teams to deliver actionable insights that drive strategic decisions and enhance customer experiences across diverse markets and stakeholders...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.