Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$100K - $120K *

Elevate patient care by providing expert pharmacy consulting and clinical services. Collaborate with a dedicated team to ensure medication safety and mentor future pharmacists while enjoying growth op...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Join a dynamic team to provide expert pharmacy consulting, educate patients on medications, and deliver clinical healthcare services while ensuring safety and compliance. Mentor colleagues and enhance...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Join us to oversee pharmacy services, ensuring quality care through effective planning, execution, and evaluation. Collaborate with healthcare teams to enhance patient outcomes while supervising staff...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$108K - $135K *

Join our team as a Telehealth Pharmacist, where you'll enhance member health through Medication Therapy Management and clinical outreach programs, ensuring high-quality care and compliance with indust...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$84K - $99K *

Join a dynamic team to evaluate and process medication prior authorization requests, ensuring compliance with clinical guidelines and regulatory standards while facilitating timely patient access to n...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$101K - $126K *

Drive the development and execution of clinical programs, ensuring effective support, education, and coordination across departments while managing health outcomes and utilization data for continuous...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Take ownership of medication therapy management services, conducting comprehensive reviews and consultations. Collaborate with the MTM product team to ensure accurate data entry and enhance patient ca...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$107K - $199K *

Redefine pharmacy care by developing formularies and policies, enhancing quality programs, and driving initiatives that improve Medicaid services while collaborating with diverse teams and stakeholder...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Transform pharmacy outcomes by leading managed care initiatives that optimize clinical programs, enhance stakeholder collaboration, and drive cost efficiencies in pharmacy benefit management...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Drive excellence in pharmacy operations by providing exceptional patient care, ensuring compliance with regulations, and fostering strong relationships with healthcare providers while managing workflo...

3 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Empower decision-making by utilizing data-driven insights to enhance operations, supporting growth through statistical modeling and AI techniques while maintaining compliance in a complex regulatory e...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a team that's dedicated to delivering exceptional patient care while supervising pharmacy staff and championing operational excellence in a compliant environment. Contribute to cultural initiativ...

Yesterday

  •   Less than 5 years exp.  •   Food & Beverages

$100K - $120K *

Drive optimal patient care by collaborating with healthcare teams to enhance medication therapy and improve clinical outcomes for patients with chronic conditions. Ensure safe medication management an...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Transform Drug Supply Chain Operations by leading cross-functional teams to establish reliable planning cadences and robust processes, ensuring continuous delivery of medication while driving efficien...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Drive medication therapy management services by conducting comprehensive reviews and consultations. Collaborate with the MTM product team to ensure accurate data entry and enhance patient care through...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $176K *

Inspire operational excellence as a strategic leader overseeing 8-10 pharmacies. Drive compliance, enhance patient care, and develop talent while ensuring consistent performance across multiple locati...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$112K - $189K *

Join us to ensure safe, effective medication therapy while advancing pharmaceutical care. Collaborate with healthcare teams, educate future practitioners, and support drug-related research to optimize...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Empower patient health by using your clinical expertise to oversee medication management and collaborate with healthcare professionals, ensuring optimal therapeutic outcomes across care settings for d...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Unlock potential by delivering expert pharmacy consulting and clinical services. Collaborate with a dedicated team to ensure medication safety, educate patients, and mentor pharmacy staff in a support...

3 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Inspire healthcare excellence by providing expert pharmacy consulting, educating patients on medication use, and ensuring safety through compliance. Collaborate with a dedicated team to deliver clinic...

3 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Drive patient-centered pharmacy services by providing expert consultations, educating on medication use, and ensuring safety through compliance. Mentor team members while delivering clinical healthcar...

3 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$108K - $184K *

Unlock potential by leveraging clinical expertise to enhance pharmacy benefit management, analyze drug trends, and build strong client relationships. Drive strategic recommendations and support client...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock potential by leading a remote pharmacy program focused on medication adherence. Collaborate with a specialized team to enhance patient care through data-driven strategies and operational suppor...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $149K *

Join a dynamic team in evaluating medication prior authorizations while developing clinical criteria and working closely with healthcare providers to ensure quality patient care through evidence-based...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$223K - $313K *

Shape the future of healthcare by leveraging your clinical expertise to review Medicare drug appeals, ensuring compliance and optimal value-based care through collaboration and analysis of complex cas...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.