Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$100K - $150K *

Join a team that's dedicated to enhancing clinical support through technical expertise and customer training. Drive product demonstrations and ensure customer satisfaction while collaborating with sal...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$110K - $130K *

Champion strategic marketing initiatives to drive growth in North America. Collaborate with cross-functional teams to develop market strategies, analyze trends, and enhance customer engagement, ensuri...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$65K - $105K *

Contribute to transformative care for underserved women by analyzing assessments, providing counseling, and collaborating with healthcare professionals in a fully remote setting. Your expertise will e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$144K - $288K *

Engage in a pivotal leadership role overseeing core network infrastructure operations. Drive stability, performance, and security across WAN and LAN environments while mentoring a skilled team and man...

RemoteRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$241K - $269K *

Drive statistical programming excellence across multiple clinical studies while collaborating with cross-functional teams. Lead validation of CRO deliverables and implement innovative tools to enhance...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead the charge in developing and overseeing scientific content across multiple therapeutic areas, ensuring high-quality contributions and strategic client interactions to drive growth and innovation...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$86K - $106K *

Drive advertiser growth by optimizing campaign performance and building strong client relationships. Collaborate with internal teams to enhance product offerings and ensure a seamless advertiser exper...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Consumer Technology

$200K - $230K *

Join a team that's shaping the future of migraine treatment by leading U.S. marketing strategies. Drive brand awareness and engagement through innovative campaigns, collaborating across functions to e...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$82K - $123K *

Reimagine patient care through comprehensive assessments and personalized treatment plans that enhance mobility, functional status, and overall well-being, while collaborating with healthcare teams in...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Deliver comprehensive patient care by assessing, diagnosing, and managing health issues. Collaborate with healthcare professionals and advocate for patients while enhancing nursing practices and suppo...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Help us enhance patient care by diagnosing and managing health issues, collaborating with healthcare teams, and advocating for individuals and communities in diverse settings. Your expertise will driv...

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $100K *

Join our dynamic team as a Technical Delivery Manager, overseeing AI-driven project delivery across diverse digital platforms. Ensure timely, high-quality outputs while leveraging innovative technolog...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$225K - $418K *

Elevate your career by leading advanced analytics initiatives that drive strategic business decisions and measurable impact. Collaborate with global teams to innovate and implement cutting-edge analyt...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $162K *

Engage with healthcare professionals to drive sales growth in the Cape Coral territory. Develop strategic business plans, conduct impactful presentations, and foster strong relationships while adherin...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$63K - $112K *

Join a team that's dedicated to enhancing client relationships and driving sales growth through effective product presentations and customer feedback. Collaborate with marketing and sales staff to ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Oversee a portfolio of clinical studies, ensuring compliance and quality. Lead Project Managers in executing complex trials, driving operational efficiency and client satisfaction while leveraging you...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Optimize reimbursement strategies and regulatory compliance by leading analysis, developing policies, and mentoring teams. Drive operational excellence and foster relationships with stakeholders to en...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$124K - $206K *

Drive the end-to-end revenue marketing strategy to enhance pipeline growth, accelerate revenue, and strengthen market positioning. Lead a cross-functional team to optimize performance and scale impact...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Transform Medicaid programs by managing initiatives, coordinating stakeholders, and driving quality improvements. Leverage your expertise to implement policies and enhance operational efficiency in a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$105K - $115K *

Optimize medical device utilization in health systems by leveraging expertise in cardiovascular, interventional radiology, and general surgery. Collaborate with stakeholders to drive cost reduction an...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$201K - $251K *

Elevate access strategies and marketing initiatives for oncology products, focusing on non-clinical value propositions. Collaborate cross-functionally to ensure successful product launches and effecti...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$117K - $146K *

Lead the charge in developing innovative algorithms and pipelines for early cancer detection, collaborating with cross-functional teams to analyze complex genomic datasets and enhance clinical diagnos...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $155K *

Lead advanced analytics and statistical modeling to transform complex healthcare data into actionable insights, collaborating with cross-functional teams to solve strategic business challenges and enh...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$160K - $200K *

Shape the future of product strategy by leading a high-performing team, driving innovation, and ensuring alignment across operations and technology to deliver exceptional customer value and measurable...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Advance innovative therapeutic programs targeting genetically driven diseases through strategic sourcing, relationship building, and cross-functional collaboration, ensuring a patient-first approach i...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.