Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$175K - $210K *

Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$130K - $160K *

Lead all HR functions in a dynamic biotech environment, enhancing employee experience and compliance while driving scalable processes and supporting leadership. Engage with teams to foster growth and...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$64K - $96K *

Engage in comprehensive risk adjustment audits and compliance reviews, ensuring accurate data submission to CMS. Collaborate with coding teams and management to uphold regulatory standards and improve...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $205K *

Join a team that's driving sales strategy for a new kidney transplant product. Leverage your expertise in account management and cross-functional collaboration to establish a strong market presence an...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$155K - $165K *

Drive success at leading Oracle Fusion Cloud projects, bridging technical expertise and financial acumen to deliver top-tier support and enhancements across Financial and Supply Chain modules with eff...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$115K - $150K *

Elevate procurement operations by managing vendor coordination, documentation, and process consistency. This role focuses on execution and queue management, ensuring timely and organized procurement s...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $205K *

Join a team that's driving innovative sales strategies for a new kidney transplant product. This role focuses on building relationships, executing strategic plans, and collaborating across functions t...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Accelerate sales growth by leading strategies and initiatives across the ANZ market. Collaborate with a multidisciplinary team to drive customer engagement, develop market strategies, and achieve reve...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Join a dynamic team to lead the development and operations of an insurance network, focusing on agency recruitment, relationship management, and service delivery to enhance member success and drive or...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Empower consumer experiences by leading product strategy and execution for innovative genomics solutions. Collaborate with cross-functional teams to enhance user satisfaction and drive adoption throug...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$185K - $230K *

Advance patient access and reimbursement strategies in rare diseases. Collaborate cross-functionally to educate providers and support patients, ensuring compliance and effective navigation of complex...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$96K - $154K *

Champion safety excellence across the region by leading safety leaders, developing strategies, and ensuring compliance with regulations. Collaborate with cross-functional teams to foster a culture of...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Transform the insurance appeals process by managing, researching, and drafting compliant responses to billing deductions. Collaborate with legal teams to enhance efficiency and build strong relationsh...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$140K - $185K *

Unlock the power of enterprise data as you design and implement Master Data Management solutions that enhance healthcare operations, drive analytics, and enable AI-driven decision-making with trusted...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$75K - $90K *

Empower your career by joining a dedicated clinical team providing psychological services in long-term care. Enjoy professional autonomy, a flexible schedule, and robust support while making a meaning...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$136K - $230K *

Elevate customer success by delivering Professional Services engagements, including installation, migration, and training, while collaborating with project managers to enhance delivery consistency and...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Elevate the development of innovative chemical processes by optimizing existing routes and synthesizing key intermediates. Collaborate with teams to ensure project success while maintaining safety and...

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$164K - $305K *

Join a team that's redefining account management by driving growth and retention for complex health systems. Build strategic relationships with C-suite executives and lead cross-functional teams to de...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$163K - $203K *

Lead the charge in executing compliance strategies across regulated sectors, ensuring robust oversight and operational clarity while collaborating with cross-functional teams to navigate regulatory la...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$82K - $112K *

Shape compelling product narratives by leveraging market insights and AI tools. Collaborate cross-functionally to drive go-to-market strategies, ensuring impactful messaging and training materials tha...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $192K *

Drive success by managing strategic merchant partnerships, blending account management and operations to enhance performance and growth. Collaborate cross-functionally to deliver scalable solutions an...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Transportation

$110K - $130K *

Lead the optimization of cross-pillar workflows, ensuring technical soundness and operational effectiveness. Collaborate with engineering and product teams to enhance product adoption and drive measur...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$173K - $310K *

Transform clinical AI solutions by leveraging your expertise in patient care and research. Collaborate cross-functionally to enhance clinical accuracy and support strategic partnerships, ensuring the...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$143K - $185K *

Unlock potential by leading clinical data management for innovative cell therapy studies. Collaborate cross-functionally to ensure data integrity and compliance while managing teams and external partn...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Join a team that's redefining sales excellence by driving revenue growth and market expansion for innovative SynBio products. Lead a dynamic team, develop strategies, and enhance customer experiences...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.