Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$210K - $230K *

Lead the charge in developing enterprise pricing strategies that optimize profitability and drive growth across diverse service sectors, ensuring alignment with market conditions and client needs whil...

RemoteRemote

3 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$110K - $130K *

Join a team that's shaping the future of Quality Control laboratories by providing technical oversight for startup, validation, and compliance across multiple manufacturing sites, ensuring operational...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion clinical trial excellence by managing projects from initiation to completion, ensuring compliance and quality standards while collaborating with cross-functional teams to drive successful out...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$81K - $112K *

Develop and optimize enterprise-grade Power BI semantic models, enhancing analytics capabilities across the organization. Collaborate with cross-functional teams to deliver high-performance solutions...

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$180K - $220K *

Drive the product vision and strategy for integrated hardware and software ecosystems, overseeing complex technology development while leading a team of Product Managers to achieve growth and innovati...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Transportation

$110K - $130K *

Unlock potential by leading product strategy for patient recruitment, enhancing engagement and operational efficiency. Collaborate with cross-functional teams to drive measurable outcomes and improve...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Empower a dynamic sales team as a player-coach, driving growth in the dental market. Lead, coach, and sell while fostering accountability and performance improvement to achieve team goals and enhance...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $130K *

Shape the future of our sales strategy by developing plans that align with business objectives and drive measurable goals, ensuring effective implementation and collaboration across regional teams to...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Drive analytical solutions by leading projects, applying advanced data analysis, and collaborating with clients to deliver actionable insights across energy initiatives including efficiency and sustai...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Drive impactful data analysis and risk management for global clinical trials, interpreting complex data to identify trends and risks. Lead cross-functional teams in enhancing study quality and patient...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$73K - $125K *

Transform clinical review processes by conducting thorough prepayment and post-payment assessments of inpatient admissions. Leverage your expertise to ensure compliance, support appeals, and enhance q...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Transform your career by driving new revenue growth in diverse industries. As a key sales leader, you'll identify prospects, develop relationships, and deliver tailored marketing solutions, ensuring c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$106K - $172K *

Elevate veterinary care by interpreting digital cytology and hematology cases. Collaborate with veterinarians, ensure quality control, and contribute to outreach efforts while maintaining high standar...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock financial potential by analyzing complex healthcare contracts and data. Collaborate with health systems to translate insights into measurable outcomes, driving operational value and shaping AI...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$211K - $290K *

Champion global regulatory strategies to drive product approvals and market access for innovative dental solutions. Collaborate with cross-functional teams to navigate complex regulatory landscapes an...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $156K *

Drive data excellence by leading analytics initiatives, enhancing governance, and integrating systems. Collaborate with leadership to deliver impactful insights and ensure compliance while leveraging...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Staffing

$235K - $270K *

Transform the landscape of oncology sales by driving growth within your territory. Collaborate with sales teams to identify opportunities, engage with key accounts, and promote cutting-edge diagnostic...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$137K - $185K *

Elevate procurement strategies by analyzing supplier performance and collaborating cross-functionally to ensure material availability and operational efficiency, driving continuous improvement in supp...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Engineer advanced protein design models and collaborate with experts to innovate in AI Drug Discovery, driving the development of candidate antibody therapeutics through deep learning and systems biol...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$132K - $221K *

Drive enterprise-wide legal support for global contracting activities, focusing on procurement and technology transactions. Collaborate with cross-functional teams to manage risks and ensure complianc...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$72K - $97K *

Accelerate progress at clinical trials by supporting regional study delivery, ensuring quality standards, and collaborating with key stakeholders to meet study goals within timelines and budget...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Drive strategic initiatives by developing KPI frameworks and operational dashboards, analyzing performance data, and collaborating across teams to enhance business outcomes and support informed decisi...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$200K - $250K *

Champion the evolution of fraud prevention strategies, enhancing customer experience while safeguarding against risks. Collaborate cross-functionally to design innovative solutions that balance securi...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$210K - $250K *

Drive strategic financial planning and analysis to optimize resource allocation, support executive decision-making, and enhance operational performance across the organization, ensuring alignment with...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$173K - $320K *

Shape the future of rheumatology by providing strategic medical oversight across clinical trials. Lead the innovation and development of groundbreaking therapies while collaborating with multidiscipli...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.