Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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1,000+

Jobs in North Carolina

Average Salary in USD

Average Salary: $114,677

Sort By: Relevance

$90K - $110K *

Join a thriving network of providers; handle outpatient care with a supportive team, minimal call, and a focus on quality patient interactions, utilizing Epic EMR and benefiting from a collegial envir...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$103K - $125K *

Lead the vision and roadmap for Edge Fabric capabilities, translating customer needs into actionable technical requirements. Collaborate across teams to prioritize product backlogs, ensure delivery re...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$129K - $210K *

Empower organizations by designing scalable data management solutions, collaborating with customers and partners to drive adoption and success. Act as a key technical advisor, bridging teams to ensure...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Consumer Technology

$135K - $160K *

Lead the charge in building AI-powered engineering systems that enhance developer workflows, ensuring reliability and ease of adoption for engineers. Collaborate with teams to create innovative soluti...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$132K - $198K *

Elevate quality assurance practices by leading test strategy and execution for customer implementations. Collaborate with teams to enhance product quality, mitigate risks, and establish scalable testi...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Consumer Technology

$88K - $105K *

Lead and inspire a dedicated team in a fast-paced Neuroscience ICU, ensuring exceptional patient care and operational excellence while fostering a supportive environment for staff development and coll...

Today

  •   Less than 5 years exp.  •   Healthcare

$80K - $115K *

Drive the advancement of nursing excellence by developing educational programs, mentoring staff, and implementing evidence-based practices in a collaborative environment focused on children's perioper...

Today

  •   Less than 5 years exp.  •   Healthcare

$110K - $140K *

Join a team that's dedicated to advancing clinical research in diagnostics. This role involves site management, ensuring compliance, and supporting clinical trials, requiring travel and collaboration...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Staffing

$110K - $130K *

Support dynamic stability studies and provide technical leadership in advanced power system analyses. Collaborate with stakeholders to ensure reliability and compliance while mentoring engineers and e...

Today

  •   8 - 10 years exp.  •   Energy & Utilities

$165K - $175K *

Lead the charge in managing global clinical trials, overseeing cross-functional teams, and ensuring project objectives are met across multiple therapeutic areas while driving operational excellence an...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Staffing

$71K - $112K *

Unlock your potential by leading QA automation efforts to enhance product quality. Collaborate with engineering teams to develop automated testing solutions for UI, APIs, and integrations, ensuring se...

Today

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Lead dynamic stability studies and provide technical expertise to enhance grid reliability. Collaborate with stakeholders to evaluate system performance and drive innovative solutions for transmission...

Today

  •   8 - 10 years exp.  •   Energy & Utilities

$123K - $200K *

Drive Regulatory Remediation Assurance efforts, leading a team to develop strategies that minimize technology risks. Collaborate with executives and stakeholders to implement effective governance and...

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$162K - $203K *

Transform your career by engaging with key opinion leaders in Urology and Women's Health. Leverage your scientific expertise to drive medical strategies and foster relationships that enhance product u...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$107K - $199K *

Optimize cost recovery initiatives by managing vendor partnerships and streamlining processes. Collaborate with health plans to achieve budget targets and present actionable insights to senior managem...

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  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in managing complex ITS and traffic management projects, overseeing planning, design, and deployment. Collaborate with multidisciplinary teams to enhance transportation systems and imp...

Today

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $160K *

Unlock potential by leading our channel strategy for System Integrators and Mechatronics across the Americas. Drive sales growth, enhance partner relationships, and implement successful initiatives to...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$152K - $253K *

Transform healthcare delivery by leveraging health information technology to enhance patient care and operational efficiency. Collaborate with health systems and cross-functional teams to align techno...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$105K - $149K *

Transform complex Consumer-Directed Health implementations for major employers. Lead strategy, execution, and client engagement while serving as a subject-matter expert to ensure operational excellenc...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Grow your career with a dynamic team as you lead operations in a healthcare facility, focusing on patient care, team development, and financial management while fostering a culture of continuous impro...

Today

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Shape the future of avionics sales by leading business development efforts, engaging military and commercial aerospace customers, and driving strategic growth in the Americas through innovative test s...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$130K - $155K *

Champion innovative manufacturing processes by leading engineering teams to enhance efficiency, safety, and quality across multiple sites. Drive continuous improvement initiatives and collaborate with...

Today

  •   8 - 10 years exp.  •   Energy & Utilities

$150K - $180K *

Pioneer the strategy and execution of data platforms and AI products, leading cross-functional teams to enhance commercial life sciences solutions while driving revenue growth and product adoption in...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$88K - $105K *

Shape Cencosud's external communications strategy, fostering relationships with media and stakeholders. Drive community engagement initiatives, manage reputational risks, and ensure alignment with cor...

Reposted today

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$78K - $120K *

Transform claims operations as you empower clients by driving adoption of innovative solutions, optimizing processes, and enhancing business outcomes in the First Party Casualty landscape across vario...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.