Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Average Salary: $114,677
Seeking a Family Medicine Physician Assistant in Brevard, NC
$90K - $110K *
Join a thriving network of providers; handle outpatient care with a supportive team, minimal call, and a focus on quality patient interactions, utilizing Epic EMR and benefiting from a collegial envir...
Reposted today
$103K - $125K *
Lead the vision and roadmap for Edge Fabric capabilities, translating customer needs into actionable technical requirements. Collaborate across teams to prioritize product backlogs, ensure delivery re...
Today
Senior Domain Architect (Data Management)
$129K - $210K *
Empower organizations by designing scalable data management solutions, collaborating with customers and partners to drive adoption and success. Act as a key technical advisor, bridging teams to ensure...
Today
Senior Software Engineer, AI Developer Experience
$135K - $160K *
Lead the charge in building AI-powered engineering systems that enhance developer workflows, ensuring reliability and ease of adoption for engineers. Collaborate with teams to create innovative soluti...
Today
Test Manager, Professional Services
$132K - $198K *
Elevate quality assurance practices by leading test strategy and execution for customer implementations. Collaborate with teams to enhance product quality, mitigate risks, and establish scalable testi...
Reposted today
RN Patient Services Manager III - Neuroscience Intensive Care Unit (NSICU)
$88K - $105K *
Lead and inspire a dedicated team in a fast-paced Neuroscience ICU, ensuring exceptional patient care and operational excellence while fostering a supportive environment for staff development and coll...
Today
RN Clinical Nurse Education Specialist - Children's Peri-Op Services
$80K - $115K *
Drive the advancement of nursing excellence by developing educational programs, mentoring staff, and implementing evidence-based practices in a collaborative environment focused on children's perioper...
Today
$110K - $140K *
Join a team that's dedicated to advancing clinical research in diagnostics. This role involves site management, ensuring compliance, and supporting clinical trials, requiring travel and collaboration...
Today
Lead Engineer - Grid Stability Studies
$110K - $130K *
Support dynamic stability studies and provide technical leadership in advanced power system analyses. Collaborate with stakeholders to ensure reliability and compliance while mentoring engineers and e...
Today
Sr. Clinical Project Manager - 1765 - 177217
$165K - $175K *
Lead the charge in managing global clinical trials, overseeing cross-functional teams, and ensuring project objectives are met across multiple therapeutic areas while driving operational excellence an...
Today
$71K - $112K *
Unlock your potential by leading QA automation efforts to enhance product quality. Collaborate with engineering teams to develop automated testing solutions for UI, APIs, and integrations, ensuring se...
Today
Lead Engineer - Grid Stability Studies
$110K - $130K *
Lead dynamic stability studies and provide technical expertise to enhance grid reliability. Collaborate with stakeholders to evaluate system performance and drive innovative solutions for transmission...
Today
Sr. Manager, Information Security - U.S. Regulatory Remediation Assurance Lead
$123K - $200K *
Drive Regulatory Remediation Assurance efforts, leading a team to develop strategies that minimize technology risks. Collaborate with executives and stakeholders to implement effective governance and...
Reposted today
Medical Science Liaison /Senior Medical Science Liaison - Specialty - Northeast Region
$162K - $203K *
Transform your career by engaging with key opinion leaders in Urology and Women's Health. Leverage your scientific expertise to drive medical strategies and foster relationships that enhance product u...
Today
Senior Manager, Payment Integrity - Vended Audit Programs
$107K - $199K *
Optimize cost recovery initiatives by managing vendor partnerships and streamlining processes. Collaborate with health plans to achieve budget targets and present actionable insights to senior managem...
Today
$110K - $130K *
Lead the charge in managing complex ITS and traffic management projects, overseeing planning, design, and deployment. Collaborate with multidisciplinary teams to enhance transportation systems and imp...
Today
$100K - $160K *
Unlock potential by leading our channel strategy for System Integrators and Mechatronics across the Americas. Drive sales growth, enhance partner relationships, and implement successful initiatives to...
Reposted today
Manager, Health Informatics (Midwest)
$152K - $253K *
Transform healthcare delivery by leveraging health information technology to enhance patient care and operational efficiency. Collaborate with health systems and cross-functional teams to align techno...
Today
Lead Consultant CDH Implementation
$105K - $149K *
Transform complex Consumer-Directed Health implementations for major employers. Lead strategy, execution, and client engagement while serving as a subject-matter expert to ensure operational excellenc...
Today
$80K - $95K *
Grow your career with a dynamic team as you lead operations in a healthcare facility, focusing on patient care, team development, and financial management while fostering a culture of continuous impro...
Today
Strategic Business Developer 5
$120K - $145K *
Shape the future of avionics sales by leading business development efforts, engaging military and commercial aerospace customers, and driving strategic growth in the Americas through innovative test s...
Today
Director Manufacturing & Industrial Engineering
$130K - $155K *
Champion innovative manufacturing processes by leading engineering teams to enhance efficiency, safety, and quality across multiple sites. Drive continuous improvement initiatives and collaborate with...
Today
Director, Technical Product Management
$150K - $180K *
Pioneer the strategy and execution of data platforms and AI products, leading cross-functional teams to enhance commercial life sciences solutions while driving revenue growth and product adoption in...
Reposted today
$88K - $105K *
Shape Cencosud's external communications strategy, fostering relationships with media and stakeholders. Drive community engagement initiatives, manage reputational risks, and ensure alignment with cor...
Reposted today
Product Client Success Manager (First Party Casualty)
$78K - $120K *
Transform claims operations as you empower clients by driving adoption of innovative solutions, optimizing processes, and enhancing business outcomes in the First Party Casualty landscape across vario...
Reposted today
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.