Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Average Salary: $114,788
$243K - $364K *
Lead the charge in designing and deploying large-scale AI systems that foster innovation and modernization. Collaborate with leadership to navigate complex technical challenges, mentor teams, and esta...
Reposted 1 week ago
BEST Technical Sales Trainee - Equipment - Charlotte, NC
$85K - $102K *
Join a team that's dedicated to developing recent engineering graduates into skilled sales professionals through a structured 6-month training program, combining technical expertise with hands-on expe...
1 week ago
$110K - $130K *
Transform your career by leading complex software projects and delivering high-quality solutions. Collaborate across teams to shape the future of our systems while mentoring peers and advocating for e...
1 week ago
Director, Lab Systems Software Development Engineering
$135K - $160K *
Transform the landscape of laboratory systems by leading software engineering strategy and execution. Drive excellence in high-quality software delivery while fostering collaboration across teams to m...
1 week ago
Director, Lab Systems Software Development Engineering
$135K - $160K *
Shape the future of laboratory systems by leading software engineering strategy and execution. Drive excellence in high-quality software delivery while fostering collaboration across teams to meet ent...
1 week ago
Manager, Executive Compensation
$115K - $130K *
Champion executive compensation strategies by managing program administration, collaborating with HR partners, and conducting market research to enhance compensation practices and support organization...
1 week ago
Front Line Manufacturing Manager (Bulk Drug Substance - Upstream) - Night Shift
$106K - $143K *
Elevate your career by leading a dynamic manufacturing team on night shifts. Drive compliance and continuous improvement in a GMP environment while mentoring staff and optimizing production processes...
1 week ago
Regulatory Writing Senior Manager
$139K - $188K *
Unlock potential by leading regulatory writing for complex submissions, mentoring junior writers, and driving departmental initiatives. Collaborate with cross-functional teams to ensure compliance and...
1 week ago
EverPro - FP&A Senior Analyst (Remote, US or Hybrid, Denver)
$100K - $115K *
Champion financial insights and strategic modeling for home services, partnering with stakeholders to drive growth. Leverage FP&A expertise to manage budgets, forecasts, and variance analysis, ensurin...
1 week ago
Sr. Financial Planning Strategist
$130K - $150K *
Empower our High Net Worth Planning Services by providing expert financial strategies. Engage with advisors to deliver tailored solutions, addressing complex planning issues while mentoring junior tea...
Reposted 1 week ago
Distinguished Engineer, Frontier Agentic AI (Remote)
$235K - $350K *
Empower the future of cybersecurity AI by leading innovative research and development. Collaborate with experts to create advanced systems that enhance defense capabilities and transform security oper...
1 week ago
Staff Product Marketing Manager, Cloud Risk & Developer Security (Remote)
$145K - $220K *
Drive impactful product marketing strategies for proactive security solutions, guiding market positioning, launches, and customer engagement. Collaborate with cross-functional teams to shape product d...
1 week ago
Executive Director, Corporate Real Estate Services
$160K - $200K *
Oversee global real estate strategy for a multinational organization, optimizing a diverse portfolio across 50+ countries. Drive cost efficiency, workplace transformation, and operational excellence w...
1 week ago
Senior Regulatory Strategist, Advertising & Promotion (work from home)
$120K - $145K *
Empower regulatory excellence by guiding cross-functional teams in compliance and strategy. Leverage deep FDA knowledge to influence promotional materials and ensure adherence to evolving regulations...
1 week ago
Regulatory Strategy Consultant
$125K - $150K *
Drive regulatory strategy across major programs, leading high-impact submissions and authority engagement. Collaborate with cross-functional teams to optimize clinical development and ensure complianc...
1 week ago
Senior / Global Regulatory Labeling Strategist
$125K - $150K *
Champion global labeling strategy for innovative therapies, leading complex initiatives from development to post-approval. Collaborate with cross-functional teams to ensure compliance and high-quality...
1 week ago
Country Study Manager - FSP - East Coast
$110K - $130K *
Join a team that's dedicated to advancing clinical research through comprehensive trial management, vendor oversight, and strategic operations, ensuring successful delivery of studies from initiation...
Reposted 1 week ago
Senior Regulatory Affairs Associate - CTA Senior Specialist
$110K - $130K *
Join a team that's advancing global health by supporting critical clinical trial submissions. In this role, you'll lead regulatory strategies, ensure compliance, and collaborate with diverse teams to...
1 week ago
Senior Consulting Engineer Physical Security
$107K - $150K *
Engage with clients to design and implement advanced Physical Security Systems. Collaborate with top engineers on complex projects, ensuring high-quality solutions and customer satisfaction while mana...
1 week ago
$80K - $95K *
Drive purchasing excellence and strategic alignment by managing supplier portfolios, negotiating optimal contracts, and ensuring timely delivery of materials to support operational success...
Reposted 1 week ago
Mechanical Engineer Specialist - Structural Analysis (Nuclear)
$95K - $115K *
Join a team that's dedicated to advancing nuclear engineering solutions. Leverage your expertise in structural analysis to enhance product performance and ensure compliance with industry standards whi...
1 week ago
Director, Medical Digital Solutions
$192K - $252K *
Champion digital transformation by optimizing medical technology solutions and enhancing HCP engagement strategies. Drive adoption and value realization of innovative tools across Field Medical teams...
1 week ago
Sr. Principal Software and AI Engineer
$137K - $182K *
Architect and drive AI-powered applications for drug development, focusing on protocol generation and clinical trials. Lead technical direction, mentor engineers, and ensure compliance while fostering...
1 week ago
New Product Development Program Manager
$123K - $169K *
Drive your career with end-to-end management of new product development programs, ensuring alignment across teams and delivering innovative solutions for critical digital infrastructure in a dynamic e...
1 week ago
Global Product Line Manager - Modular
$176K - $243K *
Drive product portfolio expansion for Modular Datacenter Infrastructure, ensuring market leadership through strategic planning, P&L management, and fostering innovation. Lead a diverse team to enhance...
1 week ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.