Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Average Salary: $114,696
Risk and Central Monitoring Associate Manager
$65K - $130K *
Contribute to clinical trial success by leading risk management and central monitoring activities. Collaborate with cross-functional teams to ensure compliance with ICH GCP guidelines and enhance qual...
Reposted 6 days ago
Senior Site Activation Manager (US/CANADA)
$107K - $213K *
Join a team that's redefining clinical research by leading site activation strategies and ensuring efficient study start-up activities. Collaborate globally to drive operational excellence and mentor...
6 days ago
Senior Legal Contract Manager (US)
$78K - $156K *
Join a dynamic team as you manage complex commercial contracts, balancing legal and business needs. Collaborate with cross-functional stakeholders to drive negotiations and enhance contracting process...
Reposted 6 days ago
Senior Clinical Research Associate - Oncology (US)
$250K - $250K+*
Join a team that's at the forefront of clinical research, overseeing site management and ensuring compliance throughout all study phases, while contributing to impactful oncology studies and enhancing...
Reposted 6 days ago
Senior Clinical Trial Manager - Metabolic - U.S.
$112K - $222K *
Lead clinical site management teams through project lifecycle, ensuring effective monitoring and communication. Drive project deliverables, budget management, and sponsor engagement to achieve impactf...
Reposted 6 days ago
Senior Site Identification and Relationship Manager - US/Mexico City/Argentina - Remote
$90K - $178K *
Drive post-award site identification efforts by developing strategies, managing feasibility questionnaires, training resources, and coordinating outreach to ensure optimal site activation and client c...
Reposted 6 days ago
Senior Clinical Research Associate- CNS -Psychiatry - East Coast
$97K - $193K *
Transform clinical research by managing site activities and ensuring compliance throughout the study lifecycle. Collaborate with teams to enhance patient safety and quality while supporting regulatory...
Reposted 6 days ago
IBPE Sr. Manager - Scenario Planning & Automation
$120K - $145K *
Unlock potential by leading supply chain risk management and optimization initiatives. Collaborate across functions to enhance inventory performance, drive operational efficiency, and leverage advance...
6 days ago
Project Leader/Scientist II - Analytical Development
$110K - $138K *
Join a dynamic team to lead analytical method development, ensuring high-quality data generation and effective communication. Oversee cross-functional efforts, mentor staff, and drive innovative solut...
6 days ago
IBPE Scenario Planning & Automation Specialist, Senior
$95K - $115K *
Elevate supply chain efficiency by developing automation solutions and data pipelines. Leverage your expertise in Python, SQL, and Power BI to enhance visibility and streamline operations, enabling pr...
6 days ago
Business Unit Strategy Analyst Specialist, Rate Strategy Execution
$80K - $95K *
Unlock potential by driving end-to-end execution of rate changes in cash products. Collaborate across teams to enhance operational processes, manage risks, and implement innovative solutions for a bes...
6 days ago
Portfolio Governance & Workforce Strategy Lead
$110K - $130K *
Lead the charge in workforce planning and financial governance, optimizing resource allocation and strategic investments. Collaborate with leadership to enhance operational effectiveness and drive con...
6 days ago
$93K - $97K *
Contribute to program success by supporting planning, execution, and management of projects. Analyze data, prepare reports, and optimize resources to ensure objectives are met within scope, time, and...
6 days ago
Senior Director, Integrated Risk Management
$126K - $191K *
Lead the charge in implementing an integrated risk framework across the enterprise, enhancing resilience and oversight while guiding teams in risk management, business continuity, and crisis response...
6 days ago
Medical Affairs and Evidence Generation Asset Lead – Executive Director
$325K - $447K *
Elevate medical affairs by providing strategic insights for clinical asset development and commercialization. Lead cross-functional teams, execute evidence generation plans, and foster collaboration t...
Reposted 6 days ago
$105K - $125K *
Unlock potential by leading technical solutions for customer implementations, managing design and integration, and ensuring operational readiness. Collaborate with cross-functional teams to deliver in...
6 days ago
$95K - $115K *
Help us lead tax engagements for veterinary practices, managing client relationships and providing expert compliance and planning support while developing team members and optimizing workflows across...
6 days ago
Senior Business Development Strategy & Operations Specialist
$102K - $135K *
Transform business development operations by leading CRM initiatives, optimizing processes, and enhancing reporting. Collaborate across teams to drive strategic growth and improve organizational effec...
6 days ago
$62K - $104K *
Drive sales growth by leading a dynamic team, developing strategies, and maximizing profits across multiple locations. Foster customer relationships and enhance market presence through effective manag...
6 days ago
$80K - $95K *
Accelerate progress at the forefront of pharmaceutical analytics by leading a dynamic laboratory team. Drive quality, mentor talent, and manage client projects to ensure excellence in pre-commercial a...
6 days ago
$120K - $145K *
Engage in technical leadership and project management to develop industry standards and reports. Collaborate with working groups to drive best practices and support continuous improvement initiatives...
6 days ago
$85K - $105K *
Unlock your potential by leading a dynamic team to enhance customer experiences, drive business growth, and foster a culture of excellence. Balance strategic and operational priorities while inspiring...
6 days ago
District Sales Manager- Water Treatment
$90K - $110K *
Join a team that's dedicated to managing and expanding industrial water treatment accounts across Ohio and Indiana. Leverage your technical expertise and consultative selling skills to drive growth an...
6 days ago
Director, Fleet Safety and Compliance
$101K - $129K *
Elevate your career by leading fleet safety and compliance initiatives. Drive innovative strategies to ensure a safe, efficient fleet while fostering a culture of safety across diverse teams and progr...
6 days ago
Senior Manager, Accreditation Systems Integrity
$89K - $125K *
Support the evolution of accreditation systems by managing and enhancing operational processes. Collaborate with cross-functional teams to drive continuous improvement and ensure compliance, efficienc...
6 days ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.