Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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1,000+

Jobs in North Carolina

Average Salary in USD

Average Salary: $114,696

Sort By: Relevance

$65K - $130K *

Contribute to clinical trial success by leading risk management and central monitoring activities. Collaborate with cross-functional teams to ensure compliance with ICH GCP guidelines and enhance qual...

RemoteRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$107K - $213K *

Join a team that's redefining clinical research by leading site activation strategies and ensuring efficient study start-up activities. Collaborate globally to drive operational excellence and mentor...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$78K - $156K *

Join a dynamic team as you manage complex commercial contracts, balancing legal and business needs. Collaborate with cross-functional stakeholders to drive negotiations and enhance contracting process...

Durham, NCRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$250K - $250K+*

Join a team that's at the forefront of clinical research, overseeing site management and ensuring compliance throughout all study phases, while contributing to impactful oncology studies and enhancing...

Durham, NCRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$112K - $222K *

Lead clinical site management teams through project lifecycle, ensuring effective monitoring and communication. Drive project deliverables, budget management, and sponsor engagement to achieve impactf...

Durham, NCRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $178K *

Drive post-award site identification efforts by developing strategies, managing feasibility questionnaires, training resources, and coordinating outreach to ensure optimal site activation and client c...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$97K - $193K *

Transform clinical research by managing site activities and ensuring compliance throughout the study lifecycle. Collaborate with teams to enhance patient safety and quality while supporting regulatory...

Durham, NCRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Unlock potential by leading supply chain risk management and optimization initiatives. Collaborate across functions to enhance inventory performance, drive operational efficiency, and leverage advance...

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $138K *

Join a dynamic team to lead analytical method development, ensuring high-quality data generation and effective communication. Oversee cross-functional efforts, mentor staff, and drive innovative solut...

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Elevate supply chain efficiency by developing automation solutions and data pipelines. Leverage your expertise in Python, SQL, and Power BI to enhance visibility and streamline operations, enabling pr...

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock potential by driving end-to-end execution of rate changes in cash products. Collaborate across teams to enhance operational processes, manage risks, and implement innovative solutions for a bes...

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in workforce planning and financial governance, optimizing resource allocation and strategic investments. Collaborate with leadership to enhance operational effectiveness and drive con...

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$93K - $97K *

Contribute to program success by supporting planning, execution, and management of projects. Analyze data, prepare reports, and optimize resources to ensure objectives are met within scope, time, and...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$126K - $191K *

Lead the charge in implementing an integrated risk framework across the enterprise, enhancing resilience and oversight while guiding teams in risk management, business continuity, and crisis response...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$325K - $447K *

Elevate medical affairs by providing strategic insights for clinical asset development and commercialization. Lead cross-functional teams, execute evidence generation plans, and foster collaboration t...

United StatesRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$105K - $125K *

Unlock potential by leading technical solutions for customer implementations, managing design and integration, and ensuring operational readiness. Collaborate with cross-functional teams to deliver in...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Transportation

$95K - $115K *

Help us lead tax engagements for veterinary practices, managing client relationships and providing expert compliance and planning support while developing team members and optimizing workflows across...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$102K - $135K *

Transform business development operations by leading CRM initiatives, optimizing processes, and enhancing reporting. Collaborate across teams to drive strategic growth and improve organizational effec...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$62K - $104K *

Drive sales growth by leading a dynamic team, developing strategies, and maximizing profits across multiple locations. Foster customer relationships and enhance market presence through effective manag...

6 days ago

  •   Less than 5 years exp.  •   Staffing

$80K - $95K *

Accelerate progress at the forefront of pharmaceutical analytics by leading a dynamic laboratory team. Drive quality, mentor talent, and manage client projects to ensure excellence in pre-commercial a...

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Engage in technical leadership and project management to develop industry standards and reports. Collaborate with working groups to drive best practices and support continuous improvement initiatives...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $105K *

Unlock your potential by leading a dynamic team to enhance customer experiences, drive business growth, and foster a culture of excellence. Balance strategic and operational priorities while inspiring...

6 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$90K - $110K *

Join a team that's dedicated to managing and expanding industrial water treatment accounts across Ohio and Indiana. Leverage your technical expertise and consultative selling skills to drive growth an...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$101K - $129K *

Elevate your career by leading fleet safety and compliance initiatives. Drive innovative strategies to ensure a safe, efficient fleet while fostering a culture of safety across diverse teams and progr...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$89K - $125K *

Support the evolution of accreditation systems by managing and enhancing operational processes. Collaborate with cross-functional teams to drive continuous improvement and ensure compliance, efficienc...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.