Explore North Carolina Jobs Paying $100K or More

Discover professional opportunities across North Carolina with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking their next career move, from senior individual-contributor positions to executive leadership. Explore openings in major employment centers such as Charlotte, Raleigh, Durham, and Greensboro, as well as opportunities across the state.

Find Opportunities Across North Carolina

North Carolina offers a diverse job market shaped by financial services, technology, healthcare, life sciences, manufacturing, and professional services. Charlotte is a major hub for banking and corporate leadership, while the Raleigh-Durham region is known for technology, research, healthcare, and life sciences. Opportunities may also be available in Greensboro, Winston-Salem, Asheville, and other communities.

Explore Senior Roles Across Industries

Search for experienced-level roles in areas such as technology, finance, operations, sales, marketing, healthcare, engineering, and general management. Job titles, qualifications, work arrangements, and compensation vary by employer. Review each listing for details and identify opportunities that match your background and career goals.

Advance Your Career With Ladders

Ladders focuses on vetted professional jobs paying $100,000 or more, helping experienced candidates explore opportunities aligned with their expertise. Use this page to browse North Carolina openings, compare roles, and discover your next step. Listings and availability change, so check back regularly for new opportunities.

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1,000+

Jobs in North Carolina

Average Salary in USD

Average Salary: $115,032

Sort By: Relevance

$136K - $204K *

Optimize platform capabilities by managing AI/ML tech areas, prioritizing stakeholder needs, and enhancing developer experience while ensuring reliability and cost-effective scaling across integration...

3 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$120K - $140K *

Drive efficiency by automating GTM processes, enhancing lead management, and integrating systems. Collaborate with Sales and Marketing to eliminate manual tasks and improve data accuracy, ensuring a s...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$200K - $265K *

Lead enterprise data strategy by defining governance frameworks and driving data-driven decision-making. Collaborate with cross-functional teams to enhance data capabilities, ensuring compliance and o...

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $125K *

Pioneer the implementation of Interactive Response Technology (IRT) in clinical studies. Lead cross-functional teams, manage timelines, and ensure compliance while providing expert guidance and suppor...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $142K *

Unlock potential by leading clinical trial monitoring efforts, ensuring compliance and data integrity while collaborating with study teams. Your expertise will enhance patient safety and contribute to...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$215K - $240K *

Lead the charge in territory sales strategy, driving revenue growth while coaching Business Development Directors and fostering client relationships. Collaborate with senior leadership to optimize per...

Durham, NCRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Engineer secure, scalable Power Platform solutions, driving architecture, governance, and integration across Microsoft ecosystems. Collaborate with teams to enhance capabilities and ensure compliance...

3 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$205K - $341K *

Unlock your potential by leading regulatory strategies for advertising and promotion. Collaborate with cross-functional teams to ensure compliance and drive successful commercialization initiatives in...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Engage in shaping a robust Environmental, Health, Safety, and Sustainability culture across 2,200+ retail locations. Collaborate with leadership to ensure compliance and drive operational excellence t...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Engage with national accounts to drive sales and enhance customer satisfaction. Leverage local relationships and coordinate with internal teams to implement strategic growth plans in the fleet busines...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$188K - $230K *

Join a team that's driving innovation in data center materials. You'll manage strategic accounts, lead complex negotiations, and collaborate with global teams to enhance customer relationships and dri...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$110K - $120K *

Develop your career by providing technical support and consulting to ensure successful customer integration of complex bolting solutions. Collaborate with teams to meet customer needs through effectiv...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $95K *

Develop and execute comprehensive training programs for Joint Tactical Operations, ensuring operational forces maximize JTO Interface Systems capabilities through curriculum design, instruction, and g...

3 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$93K - $210K *

Join a team that's dedicated to enhancing compensation strategies and driving business performance. Lead a talented group of professionals while collaborating with stakeholders to optimize compensatio...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Transportation

$161K - $249K *

Drive incident response and threat detection while enhancing security capabilities. Lead technical investigations, develop detection logic, and automate security processes across cloud environments to...

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Lead the charge in safety management services, ensuring compliance with regulations and company standards. Oversee departmental operations, manage staff, and drive business development initiatives to...

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Shape strategic programs and lead cross-functional teams to drive innovation and excellence. Oversee complex projects from inception to delivery, ensuring quality and alignment with organizational goa...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$108K - $162K *

Innovate in a strategic sales role, managing key accounts and driving revenue growth. Leverage technical expertise to build relationships and influence decision-making across the F5 solution portfolio...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$169K - $254K *

Lead and optimize the Solutions Engineering team in the Healthcare sector, focusing on technical sales and strategic planning. Drive team performance, manage recruitment, and ensure alignment with com...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$72K - $192K *

Join a team that's dedicated to enhancing client relationships in healthcare. As a trusted advisor, you'll guide clients through workflows, drive feature adoption, and develop strategic plans to maxim...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$137K - $228K *

Lead the enterprise AI risk and governance function, establishing a multi-year strategy and framework. Collaborate across teams to ensure responsible AI adoption while balancing regulatory expectation...

3 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$77K - $129K *

Reimagine data analytics by developing impactful dashboards and reports that enhance risk management and strategic decision-making. Collaborate with stakeholders to drive insights and streamline proce...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $134K *

Join a team that's redefining financial planning by creating comprehensive tax strategies. Collaborate with advisors to analyze client data, deliver tailored tax plans, and stay updated on tax laws to...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$62K - $103K *

Build a dynamic marketing strategy that enhances brand visibility and engagement through innovative content, social media, and thought leadership initiatives, collaborating with analysts and stakehold...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$68K - $114K *

Empower a dynamic team by leading daily operations, enhancing client experiences, and driving continuous improvement. Collaborate with leadership to implement effective processes and foster a culture...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100K-plus jobs can I find in North Carolina?question toggle

    Listings may include senior and executive opportunities across technology, finance, healthcare, life sciences, manufacturing, sales, operations, engineering, and other professional fields. Availability and requirements vary by employer.

  • Which North Carolina cities have high-paying job opportunities?question toggle

    Opportunities may be found in Charlotte, Raleigh, Durham, Greensboro, Winston-Salem, Asheville, and other parts of the state. The location of each position is shown in its listing.

  • Are North Carolina jobs on Ladders vetted?question toggle

    Ladders focuses on vetted professional jobs that pay $100,000 or more. Review each job listing for the employer, qualifications, compensation information, and application details.

  • Can I find remote or hybrid jobs based in North Carolina?question toggle

    Some employers offer remote or hybrid arrangements, but work options differ by role. Check the individual listing for its location and workplace requirements.

  • How often should I check for new North Carolina jobs?question toggle

    Listings change as employers add or fill positions. Check back regularly to see newly available opportunities that match your experience and salary goals.