Explore North Carolina Jobs Paying $100K or More

Discover professional opportunities across North Carolina with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking their next career move, from senior individual-contributor positions to executive leadership. Explore openings in major employment centers such as Charlotte, Raleigh, Durham, and Greensboro, as well as opportunities across the state.

Find Opportunities Across North Carolina

North Carolina offers a diverse job market shaped by financial services, technology, healthcare, life sciences, manufacturing, and professional services. Charlotte is a major hub for banking and corporate leadership, while the Raleigh-Durham region is known for technology, research, healthcare, and life sciences. Opportunities may also be available in Greensboro, Winston-Salem, Asheville, and other communities.

Explore Senior Roles Across Industries

Search for experienced-level roles in areas such as technology, finance, operations, sales, marketing, healthcare, engineering, and general management. Job titles, qualifications, work arrangements, and compensation vary by employer. Review each listing for details and identify opportunities that match your background and career goals.

Advance Your Career With Ladders

Ladders focuses on vetted professional jobs paying $100,000 or more, helping experienced candidates explore opportunities aligned with their expertise. Use this page to browse North Carolina openings, compare roles, and discover your next step. Listings and availability change, so check back regularly for new opportunities.

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1,000+

Jobs in North Carolina

Average Salary in USD

Average Salary: $115,032

Sort By: Relevance

$107K - $161K *

Drive impactful healthcare analytics by transforming data into actionable insights. Collaborate with stakeholders to identify cost-saving opportunities and enhance reporting strategies using advanced...

3 days ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$234K - $317K *

Lead the charge in transforming regional sales strategy for the Respiratory franchise. Drive execution across multiple states, manage a team of District Sales Managers, and align priorities to enhance...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive impactful communications strategies that enhance organizational goals. Collaborate with senior leaders to craft compelling content and engage audiences effectively, while analyzing metrics to re...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Staffing

$120K - $145K *

Transform application security practices by enhancing web, API, and cloud service protections. Collaborate with development teams to remediate vulnerabilities and integrate security into CI/CD workflo...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Elevate your career by leading safety and security initiatives across multiple hotels. Collaborate with management teams to implement crisis management plans, assess risks, and ensure compliance with...

3 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$93K - $138K *

Join a team that's dedicated to enhancing operational efficiency through innovative software solutions. As a key contributor, you'll develop and maintain applications that streamline processes, ensuri...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $120K *

Engage clients by driving sales of Managed and Professional Services, identifying opportunities, and delivering tailored solutions. Cultivate relationships to exceed revenue targets while leveraging i...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

Champion process improvement initiatives to enhance operational efficiency, reduce costs, and drive performance across the organization. Collaborate with leadership to implement Lean and Six Sigma met...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$135K - $160K *

Advance security integration by leading DevSecOps initiatives, enhancing software delivery, and establishing robust security standards across engineering teams to mitigate risks and improve efficiency...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$68K - $113K *

Lead project coordination efforts by ensuring effective communication and management of materials, schedules, and documentation. Collaborate with teams to streamline processes and enhance project effi...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$103K - $154K *

Lead the commercial success of a diverse product portfolio across North America. Drive growth, customer adoption, and lifecycle management while collaborating with cross-functional teams to align stra...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$199K - $321K *

Explore a dynamic role shaping litigation and policy strategy in the pharmaceutical sector. Collaborate with senior leaders and external stakeholders to navigate complex legal landscapes, ensuring pat...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive your career with a pivotal role in CMC regulatory affairs, ensuring compliance for biologics and small molecules. Collaborate across teams to prepare high-quality submissions and strategies, imp...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in designing and evolving a robust design system, ensuring high-quality user experiences through reusable components and patterns. Collaborate with cross-functional teams to align desi...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$135K - $200K *

Unlock potential by advancing 3D vision research through innovative algorithms and open source applications. Collaborate with experts to tackle challenges in photogrammetry and computer vision, contri...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$133K - $173K *

Lead teams to innovate and enhance robust Data & AI platforms, ensuring scalability and security. Own platform capabilities, drive strategic decisions, and mentor engineers to unlock impactful outcome...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Drive the engineering and modernization of enterprise End User Computing platforms, ensuring secure, scalable, and intuitive teammate experiences. Lead a multi-disciplinary team to enhance platform re...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$71K - $142K *

Manage eCOA project activities and vendor relationships to ensure timely delivery and compliance throughout the clinical trial lifecycle. Collaborate with global teams to oversee study design, testing...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $150K *

Engage with clients to lead technical pre-sales consulting and design efforts. Collaborate with sales teams to deliver innovative solutions across IT, Data Center, Networking, Security, and Cloud envi...

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $200K *

Lead a dynamic sales team to drive revenue growth in genetic diagnostics. Engage with healthcare professionals, manage complex relationships, and implement strategic sales initiatives across North and...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$104K - $174K *

Empower growth by managing strategic partnerships across product, sales, and marketing. Collaborate cross-functionally to enhance ecosystem performance and drive measurable business impact for partner...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$120K - $130K *

Elevate your career by leading the design and implementation of complex software solutions. Collaborate with cross-functional teams to drive technical decisions and mentor engineers, ensuring scalable...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$104K - $174K *

Champion ecosystem growth by collaborating across teams to enhance partner operations, drive strategic initiatives, and optimize performance metrics, ensuring value delivery to customers and stakehold...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Join a team that's driving integration data migration strategies and analysis. Collaborate with project teams to execute and support data governance initiatives, ensuring quality and efficiency across...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$210K - $230K *

Accelerate progress at the forefront of clinical supply chain management, leading strategic initiatives to ensure seamless delivery of investigational products for global trials while collaborating ac...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100K-plus jobs can I find in North Carolina?question toggle

    Listings may include senior and executive opportunities across technology, finance, healthcare, life sciences, manufacturing, sales, operations, engineering, and other professional fields. Availability and requirements vary by employer.

  • Which North Carolina cities have high-paying job opportunities?question toggle

    Opportunities may be found in Charlotte, Raleigh, Durham, Greensboro, Winston-Salem, Asheville, and other parts of the state. The location of each position is shown in its listing.

  • Are North Carolina jobs on Ladders vetted?question toggle

    Ladders focuses on vetted professional jobs that pay $100,000 or more. Review each job listing for the employer, qualifications, compensation information, and application details.

  • Can I find remote or hybrid jobs based in North Carolina?question toggle

    Some employers offer remote or hybrid arrangements, but work options differ by role. Check the individual listing for its location and workplace requirements.

  • How often should I check for new North Carolina jobs?question toggle

    Listings change as employers add or fill positions. Check back regularly to see newly available opportunities that match your experience and salary goals.