Discover professional opportunities across North Carolina with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking their next career move, from senior individual-contributor positions to executive leadership. Explore openings in major employment centers such as Charlotte, Raleigh, Durham, and Greensboro, as well as opportunities across the state.
North Carolina offers a diverse job market shaped by financial services, technology, healthcare, life sciences, manufacturing, and professional services. Charlotte is a major hub for banking and corporate leadership, while the Raleigh-Durham region is known for technology, research, healthcare, and life sciences. Opportunities may also be available in Greensboro, Winston-Salem, Asheville, and other communities.
Search for experienced-level roles in areas such as technology, finance, operations, sales, marketing, healthcare, engineering, and general management. Job titles, qualifications, work arrangements, and compensation vary by employer. Review each listing for details and identify opportunities that match your background and career goals.
Ladders focuses on vetted professional jobs paying $100,000 or more, helping experienced candidates explore opportunities aligned with their expertise. Use this page to browse North Carolina openings, compare roles, and discover your next step. Listings and availability change, so check back regularly for new opportunities.
Average Salary: $115,032
Senior Healthcare Data Analytics Consultant
$107K - $161K *
Drive impactful healthcare analytics by transforming data into actionable insights. Collaborate with stakeholders to identify cost-saving opportunities and enhance reporting strategies using advanced...
3 days ago
Regional Sales Director - Respiratory - East
$234K - $317K *
Lead the charge in transforming regional sales strategy for the Respiratory franchise. Drive execution across multiple states, manage a team of District Sales Managers, and align priorities to enhance...
3 days ago
$110K - $130K *
Drive impactful communications strategies that enhance organizational goals. Collaborate with senior leaders to craft compelling content and engage audiences effectively, while analyzing metrics to re...
3 days ago
Senior Application Security Engineer
$120K - $145K *
Transform application security practices by enhancing web, API, and cloud service protections. Collaborate with development teams to remediate vulnerabilities and integrate security into CI/CD workflo...
3 days ago
$100K - $120K *
Elevate your career by leading safety and security initiatives across multiple hotels. Collaborate with management teams to implement crisis management plans, assess risks, and ensure compliance with...
3 days ago
Senior Associate, Operational Intelligence, Labs
$93K - $138K *
Join a team that's dedicated to enhancing operational efficiency through innovative software solutions. As a key contributor, you'll develop and maintain applications that streamline processes, ensuri...
3 days ago
Account Executive, Managed Services
$80K - $120K *
Engage clients by driving sales of Managed and Professional Services, identifying opportunities, and delivering tailored solutions. Cultivate relationships to exceed revenue targets while leveraging i...
3 days ago
US LBM Market Continuous Improvement Manager
$95K - $115K *
Champion process improvement initiatives to enhance operational efficiency, reduce costs, and drive performance across the organization. Collaborate with leadership to implement Lean and Six Sigma met...
3 days ago
Senior Software Security Architect
$135K - $160K *
Advance security integration by leading DevSecOps initiatives, enhancing software delivery, and establishing robust security standards across engineering teams to mitigate risks and improve efficiency...
3 days ago
$68K - $113K *
Lead project coordination efforts by ensuring effective communication and management of materials, schedules, and documentation. Collaborate with teams to streamline processes and enhance project effi...
Reposted 3 days ago
Regional Product Manager (Protein Diagnostics)
$103K - $154K *
Lead the commercial success of a diverse product portfolio across North America. Drive growth, customer adoption, and lifecycle management while collaborating with cross-functional teams to align stra...
3 days ago
Senior Director, Counsel - Litigation, Legal Policy and Strategy (USA Remote role)
$199K - $321K *
Explore a dynamic role shaping litigation and policy strategy in the pharmaceutical sector. Collaborate with senior leaders and external stakeholders to navigate complex legal landscapes, ensuring pat...
3 days ago
Regulatory Affairs Consultant, CMC - Biologics
$110K - $130K *
Drive your career with a pivotal role in CMC regulatory affairs, ensuring compliance for biologics and small molecules. Collaborate across teams to prepare high-quality submissions and strategies, imp...
3 days ago
Principal UX Designer, Design Systems
$120K - $145K *
Lead the charge in designing and evolving a robust design system, ensuring high-quality user experiences through reusable components and patterns. Collaborate with cross-functional teams to align desi...
3 days ago
3D Computer Vision Researcher - Remote (US)
$135K - $200K *
Unlock potential by advancing 3D vision research through innovative algorithms and open source applications. Collaborate with experts to tackle challenges in photogrammetry and computer vision, contri...
3 days ago
Manager, Software Engineering - AI and Data Platform
$133K - $173K *
Lead teams to innovate and enhance robust Data & AI platforms, ensuring scalability and security. Own platform capabilities, drive strategic decisions, and mentor engineers to unlock impactful outcome...
Reposted 3 days ago
Infrastructure Engineering Sr. Manager-EUC Platform Engineering
$120K - $145K *
Drive the engineering and modernization of enterprise End User Computing platforms, ensuring secure, scalable, and intuitive teammate experiences. Lead a multi-disciplinary team to enhance platform re...
3 days ago
$71K - $142K *
Manage eCOA project activities and vendor relationships to ensure timely delivery and compliance throughout the clinical trial lifecycle. Collaborate with global teams to oversee study design, testing...
3 days ago
Consulting Systems Engineer - Global Service Provider
$100K - $150K *
Engage with clients to lead technical pre-sales consulting and design efforts. Collaborate with sales teams to deliver innovative solutions across IT, Data Center, Networking, Security, and Cloud envi...
3 days ago
Regional Sales Director, Carolina Region
$150K - $200K *
Lead a dynamic sales team to drive revenue growth in genetic diagnostics. Engage with healthcare professionals, manage complex relationships, and implement strategic sales initiatives across North and...
3 days ago
Manager, Ecosystem Partnerships
$104K - $174K *
Empower growth by managing strategic partnerships across product, sales, and marketing. Collaborate cross-functionally to enhance ecosystem performance and drive measurable business impact for partner...
Reposted 3 days ago
$120K - $130K *
Elevate your career by leading the design and implementation of complex software solutions. Collaborate with cross-functional teams to drive technical decisions and mentor engineers, ensuring scalable...
3 days ago
Manager, Ecosystem Partnerships
$104K - $174K *
Champion ecosystem growth by collaborating across teams to enhance partner operations, drive strategic initiatives, and optimize performance metrics, ensuring value delivery to customers and stakehold...
Reposted 3 days ago
$95K - $115K *
Join a team that's driving integration data migration strategies and analysis. Collaborate with project teams to execute and support data governance initiatives, ensuring quality and efficiency across...
3 days ago
Director, Clinical Supply Chain (or Senior)
$210K - $230K *
Accelerate progress at the forefront of clinical supply chain management, leading strategic initiatives to ensure seamless delivery of investigational products for global trials while collaborating ac...
3 days ago
What types of $100K-plus jobs can I find in North Carolina?
Listings may include senior and executive opportunities across technology, finance, healthcare, life sciences, manufacturing, sales, operations, engineering, and other professional fields. Availability and requirements vary by employer.
Which North Carolina cities have high-paying job opportunities?
Opportunities may be found in Charlotte, Raleigh, Durham, Greensboro, Winston-Salem, Asheville, and other parts of the state. The location of each position is shown in its listing.
Are North Carolina jobs on Ladders vetted?
Ladders focuses on vetted professional jobs that pay $100,000 or more. Review each job listing for the employer, qualifications, compensation information, and application details.
Can I find remote or hybrid jobs based in North Carolina?
Some employers offer remote or hybrid arrangements, but work options differ by role. Check the individual listing for its location and workplace requirements.
How often should I check for new North Carolina jobs?
Listings change as employers add or fill positions. Check back regularly to see newly available opportunities that match your experience and salary goals.