Explore North Carolina Jobs Paying $100K or More

Discover professional opportunities across North Carolina with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking their next career move, from senior individual-contributor positions to executive leadership. Explore openings in major employment centers such as Charlotte, Raleigh, Durham, and Greensboro, as well as opportunities across the state.

Find Opportunities Across North Carolina

North Carolina offers a diverse job market shaped by financial services, technology, healthcare, life sciences, manufacturing, and professional services. Charlotte is a major hub for banking and corporate leadership, while the Raleigh-Durham region is known for technology, research, healthcare, and life sciences. Opportunities may also be available in Greensboro, Winston-Salem, Asheville, and other communities.

Explore Senior Roles Across Industries

Search for experienced-level roles in areas such as technology, finance, operations, sales, marketing, healthcare, engineering, and general management. Job titles, qualifications, work arrangements, and compensation vary by employer. Review each listing for details and identify opportunities that match your background and career goals.

Advance Your Career With Ladders

Ladders focuses on vetted professional jobs paying $100,000 or more, helping experienced candidates explore opportunities aligned with their expertise. Use this page to browse North Carolina openings, compare roles, and discover your next step. Listings and availability change, so check back regularly for new opportunities.

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1,000+

Jobs in North Carolina

Average Salary in USD

Average Salary: $115,032

Sort By: Relevance

$96K - $135K *

Shape the future of business continuity by leading planning and response efforts to ensure seamless operations during disruptions. Collaborate across teams to develop and test recovery strategies that...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$145K - $175K *

Lead the charge in engineering management, guiding a cross-functional team of 4-7 engineers. Drive execution, foster growth, and ensure quality while collaborating closely with product management to d...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Drive strategic CMC regulatory leadership for late-stage and marketed products, ensuring compliance and quality in submissions. Collaborate with cross-functional teams to influence outcomes and engage...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$248K - $341K *

Elevate your career by driving regional revenue through a sophisticated sales strategy. Own the sales lifecycle, collaborate across teams, and position cutting-edge cybersecurity solutions for SLED cu...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $140K *

Drive transformative client solutions by leading end-to-end implementations of healthcare technology and analytics, ensuring projects align with client goals while managing timelines, quality, and reg...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$96K - $151K *

Join a team that's transforming healthcare by developing analytic products from clinical data. Collaborate in an agile environment to deliver insights that enhance efficacy and drive innovation in the...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $100K *

Join us to conduct field inspections of lightning protection systems, ensuring compliance with UL 96A and NFPA 780 standards. This home-based role requires independent scheduling, regional travel, and...

3 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$145K - $175K *

Join us to define and drive the enterprise cloud database strategy, leading architecture and modernization efforts to create scalable, reliable solutions for healthcare applications serving millions o...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$128K - $185K *

Elevate transportation infrastructure by leading bridge design projects, mentoring junior engineers, and collaborating with clients and stakeholders to ensure successful project delivery and complianc...

3 days ago

  •   8 - 10 years exp.  •   Business Services

$150K - $170K *

Optimize revenue operations by partnering with leadership to enhance GTM strategies, manage HubSpot systems, and drive data quality. Lead analytics and reporting while fostering cross-functional align...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K - $110K *

Elevate training effectiveness by delivering comprehensive product education across virtual, classroom, and in-field formats. Collaborate with cross-functional teams to ensure alignment with business...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$108K - $130K *

Lead the charge in executing complex business initiatives, ensuring alignment across teams and delivering impactful results. Serve as a trusted partner to senior stakeholders, driving accountability a...

3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $195K *

Shape the future of payroll and HRIS integrations by ensuring reliability and success. Collaborate with customers and partners to solve technical challenges and enhance the integration experience whil...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $180K *

Transform fraud data management by leading strategy and execution for a centralized platform. Collaborate across teams to enhance fraud detection, streamline operations, and drive measurable outcomes...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$88K - $102K *

Elevate your career by managing day-to-day financial operations, ensuring compliance, and supporting strategic financial initiatives. Collaborate with diverse teams to maintain financial health and dr...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$130K - $140K *

Lead the charge in operational excellence across multiple schools, enhancing leadership effectiveness and ensuring compliance. Collaborate with teams to drive enrollment growth and academic improvemen...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$142K - $195K *

Transform identity governance by leading the design and implementation of scalable IGA solutions. Collaborate with architects to ensure secure, operationally sound integrations and lifecycle automatio...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Transform service delivery by leading Tier 1/2 support operations, ensuring quality and performance through effective queue management, reporting, and continuous improvement initiatives in a collabora...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$166K - $200K *

Lead the charge in strategic account management by building and nurturing C-suite relationships, guiding a matrix team, and executing high-level strategies for national accounts and cancer centers acr...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$73K - $102K *

Take ownership of Oracle EBS R12 upgrade activities, including technical design, configuration, and deployment. Collaborate with teams to resolve issues and develop customizations, ensuring a smooth t...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$112K - $135K *

Drive product vision and strategy for complex, cross-functional initiatives. Manage roadmaps, prioritize features, and collaborate with teams to enhance customer experiences while ensuring alignment w...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$135K - $203K *

Join a team that's redefining Unity platform support for Android ecosystems. Collaborate on optimizing performance across devices, enabling seamless deployment for developers while enhancing user expe...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Optimize regulatory compliance and legal operations in healthcare. Collaborate with cross-functional teams to ensure adherence to industry standards while driving efficiency and effectiveness in legal...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Drive regulatory excellence in healthcare by managing compliance programs, collaborating with legal and technical teams, and enhancing operational efficiency to support innovative cancer care solution...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$113K - $115K *

Lead the charge in enhancing institutional effectiveness through strategic assessment and accreditation initiatives. Collaborate with diverse teams to implement data-driven improvements and ensure com...

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100K-plus jobs can I find in North Carolina?question toggle

    Listings may include senior and executive opportunities across technology, finance, healthcare, life sciences, manufacturing, sales, operations, engineering, and other professional fields. Availability and requirements vary by employer.

  • Which North Carolina cities have high-paying job opportunities?question toggle

    Opportunities may be found in Charlotte, Raleigh, Durham, Greensboro, Winston-Salem, Asheville, and other parts of the state. The location of each position is shown in its listing.

  • Are North Carolina jobs on Ladders vetted?question toggle

    Ladders focuses on vetted professional jobs that pay $100,000 or more. Review each job listing for the employer, qualifications, compensation information, and application details.

  • Can I find remote or hybrid jobs based in North Carolina?question toggle

    Some employers offer remote or hybrid arrangements, but work options differ by role. Check the individual listing for its location and workplace requirements.

  • How often should I check for new North Carolina jobs?question toggle

    Listings change as employers add or fill positions. Check back regularly to see newly available opportunities that match your experience and salary goals.