Explore $100K+ Jobs in Pennsylvania

Discover vetted professional opportunities across Pennsylvania with Ladders. Browse jobs with salaries of $100,000 or more, from senior leadership and management roles to specialized positions in technology, healthcare, finance, engineering, and other fields. Whether you’re looking in Philadelphia, Pittsburgh, Harrisburg, or elsewhere in the state, explore openings that match your experience and career goals.

Find opportunities across Pennsylvania

Pennsylvania’s major cities and regional business centers offer a wide range of professional career paths. Search for opportunities in metropolitan areas such as Philadelphia and Pittsburgh, as well as roles in Harrisburg, Allentown, Lancaster, and other communities. Availability varies by employer and location, so review each listing for work location and remote or hybrid details.

Browse senior and specialized roles

Explore positions for experienced professionals, including director, vice president, executive, and other senior-level roles. You can also find specialized opportunities in areas such as technology, healthcare, finance, sales, operations, and engineering. Review job requirements, responsibilities, and compensation information to identify roles suited to your expertise.

Make your next career move

Use Ladders to explore vetted jobs paying $100,000 or more in Pennsylvania. Compare opportunities, focus your search by location and profession, and apply to positions aligned with your qualifications. New listings may be added as employers seek experienced talent across the state.

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$290K - $340K *

Lead and inspire engineering teams to develop cutting-edge web and AI security solutions. Drive strategy, execution, and organizational health while fostering a culture of innovation and accountabilit...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $150K *

Lead the charge in delivering complex integrations for clients, embedding with their teams to build reusable assets against our API. Transform vague requests into actionable plans while enhancing depl...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$148K - $222K *

Unlock your potential as a Senior Solutions Engineer, driving sales success by leveraging technical expertise to address customer needs and deliver innovative F5 solutions. Collaborate with teams to e...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by driving technical integration and validation for Ambient AI Scribe initiatives. Collaborate with clinical teams to enhance workflows, troubleshoot issues, and ensure operational re...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$84K - $116K *

Lead the charge in enhancing utility infrastructure through technical expertise, engineering studies, and collaborative project execution, ensuring safety and compliance while driving improvements in...

Today

  •   Less than 5 years exp.  •   Energy & Utilities

$95K - $115K *

Lead the global rollout of a physical security platform, managing Genetec Security Center configurations and troubleshooting across 100+ locations. Collaborate with local teams to ensure seamless inte...

Today

  •   5 - 7 years exp.  •   Staffing

$120K - $140K *

Elevate data management strategies by leading the design and governance of enterprise data ecosystems. Drive innovation through advanced tools, ensuring data integrity and compliance while collaborati...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Champion the design and governance of enterprise data ecosystems, driving data management strategies and ensuring compliance. Lead teams in implementing advanced tools for scalable, secure data soluti...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Join a dynamic team to build and automate security controls across our infrastructure. You'll manage host hardening, vulnerability assessments, and compliance, leveraging AI tools to enhance security...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$175K - $251K *

Transform the future of public sector security by leading technical sales, engaging with Federal entities, and driving innovative solutions for Zero Trust transformations through expert guidance and c...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$147K - $203K *

Lead the charge in driving sales strategies for government sectors, managing complex sales cycles, and fostering relationships with key decision-makers to achieve revenue growth and budget targets...

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$107K - $195K *

Shape the future of healthcare data interoperability by leading architecture design and integration strategies for federal health programs, ensuring seamless data flow and compliance with industry sta...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Technical Services

$135K - $160K *

Lead the design and delivery of innovative Service Cloud Voice solutions, guiding clients through contact center modernization and AI adoption. Collaborate with teams to create scalable, secure archit...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Join a team that's redefining change management in healthcare. Support the adoption of innovative informatics solutions, ensuring seamless transitions and user readiness across the Veterans Health Adm...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Empower your career with senior-level expertise in data architecture and warehousing. Drive data integration and management, ensuring effective solutions for Occupational Environmental Health practice...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in managing informatics projects from planning to delivery, ensuring timely decision-making and risk management. Collaborate with cross-functional teams to enhance health information e...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$120K - $145K *

Champion the modernization of SLED organizations by guiding them through technical evaluations and deployments of GitLab's DevSecOps platform, ensuring compliance and enhancing service delivery across...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$139K - $232K *

Unlock potential by providing enterprise architecture leadership for Retail and Consumer Banking. Shape technology strategies and roadmaps across various banking capabilities, ensuring alignment with...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Lead our vulnerability management and security operations program, shaping it from the ground up. Collaborate with a small Trust team to enhance our security posture and ensure compliance while automa...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $210K *

Join a dynamic team to lead AI platform strategy and operations, ensuring seamless access and governance while driving enterprise-wide adoption and continuous improvement of innovative AI solutions...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $175K *

Grow expertise in Operational Technology security, leading critical engagements across industrial systems. Collaborate on advanced methodologies while mentoring others and contributing to pivotal rese...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $200K *

Drive enterprise sales by creating pipeline, closing complex contracts, and building strategic relationships. Collaborate with leadership to scale revenue and develop a repeatable sales motion in the...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$163K - $203K *

Shape the future of defense infrastructure by leading technical engagements and ensuring successful project execution. Collaborate with stakeholders to deliver innovative solutions that meet mission-c...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the charge in securing and optimizing OT/ICS networks for energy systems. As a senior engineer, you'll design network architectures, manage cybersecurity compliance, and collaborate with cross-fu...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$190K - $215K *

Manage the entire deal process for data center acquisitions, engaging stakeholders, negotiating terms, and driving transactions to closure. Handle multiple deals with precision while optimizing commer...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in Pennsylvania?question toggle

    Pennsylvania listings may include senior management, executive, and specialized professional roles in fields such as technology, healthcare, finance, sales, operations, and engineering. Roles and availability vary by employer.

  • Which Pennsylvania cities have professional job opportunities?question toggle

    Opportunities may be available in Philadelphia, Pittsburgh, Harrisburg, Allentown, Lancaster, and other areas across the state. Check each listing for its specific location and work arrangement.

  • Are these Pennsylvania jobs vetted?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review individual listings for details about the employer, qualifications, responsibilities, and compensation.

  • Can I find remote or hybrid jobs in Pennsylvania?question toggle

    Some employers may offer remote or hybrid arrangements, but availability varies. Check the work-location details in each job listing.