Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Channel Domain Consultant, Cortex
$206K - $283K *
Unlock potential by bridging technical expertise with strategic partner enablement. Drive partner success and market expansion through high-impact training and collaboration, ensuring effective delive...
3 weeks ago
Sr. Software Engineer (C# .NET)
$112K - $155K *
Accelerate progress at a leading tech firm by developing scalable, cloud-native APIs. Collaborate with cross-functional teams to enhance core offerings and lead discussions on software architecture, e...
3 weeks ago
$150K - $180K *
Transform cloud infrastructure by leading strategy, team development, and automation. Drive security, reliability, and cost management while collaborating across functions to enhance operational excel...
1 week ago
Staff Product Security Architect
$168K - $238K *
Drive proactive security architecture strategies to enhance software resilience, collaborating with engineering teams to embed security into development workflows while minimizing manual intervention...
Reposted today
Senior Architectural Lab Planner
$100K - $120K *
Lead the charge in planning and designing innovative laboratory facilities, collaborating with multidisciplinary teams to create flexible, compliant environments that enhance operational workflows and...
2 weeks ago
$125K - $150K *
Transform data integration in modern data centers by leading a team to design and implement edge collectors, ensuring seamless connectivity and efficient onboarding across multiple sites while collabo...
6 days ago
Technical Solutions Architect III -- Virtualization Nutanix - VmWare
$151K - $189K *
Engineer innovative virtualization solutions that enhance customer strategy and value. Collaborate in a dynamic environment, leading customer workshops as a subject-matter expert across VMware and Nut...
Reposted 2 weeks ago
$95K - $115K *
Champion innovative solutions in a dynamic, remote environment, driving sales strategy and product development for public safety agencies. Collaborate with teams to deliver impactful presentations and...
5 days ago
Software Engineer, AI Enablement
$163K - $226K *
Lead the AI enablement initiative, crafting tools and workflows to empower engineers across the organization, enhancing productivity and safety through innovative AI technologies and practices...
Reposted 2 weeks ago
Senior Cloud Operations Engineer
$120K - $145K *
Transform your career by owning AWS cloud operations, enhancing reliability, performance, and cost efficiency. Collaborate with cross-functional teams to ensure seamless service delivery and operation...
1 week ago
Senior Routing Engine Developer (CX Platform)
$120K - $145K *
Deliver innovative routing solutions for enterprise-scale contact centers. Design and build a robust routing engine that intelligently distributes interactions across various channels, ensuring high a...
2 weeks ago
$180K - $210K *
Accelerate progress at the forefront of AI integration, designing secure enterprise architectures that enhance healthcare services for Veterans. Lead initiatives across cloud and on-premise platforms...
6 days ago
$95K - $115K *
Unlock potential by designing and implementing a cloud-native architecture. Assess legacy infrastructure, create detailed design documents, and collaborate with engineering to modernize critical data...
Reposted 2 weeks ago
Director, Production and Infrastructure Engineering
$240K - $290K *
Elevate your career by leading a dynamic engineering team focused on production and infrastructure. Drive performance, foster collaboration, and deliver innovative solutions while managing diverse tec...
1 week ago
Oracle Cloud CX Architect - DCS & Service
$120K - $145K *
Elevate your career by leading the architecture and design of Oracle Cloud CX solutions. Collaborate with teams to translate business needs into scalable customer service portals while ensuring alignm...
1 week ago
Engineering Manager, Governance & Access
$150K - $180K *
Empower our team to build innovative security and governance solutions, shaping access management for both human and agent users. Lead a small, dynamic group as we define architectural foundations and...
3 weeks ago
Principal TA Systems Architect
$128K - $205K *
Elevate your career by owning the TA tech stack, driving integrations, and enhancing system efficiency. Collaborate with cross-functional teams to optimize processes and lead vendor relationships, all...
Reposted 4 days ago
Principal Consulting Engineer - VMware Cloud Foundation Operations
$164K - $240K *
Accelerate progress at the forefront of private cloud architecture by designing, deploying, and optimizing solutions. Leverage your expertise to drive standards, mentor teams, and cultivate robust cli...
Reposted 3 days ago
$170K - $200K *
Transform your career by leading strategic relationships with key national partners, driving significant sales growth while navigating complex market dynamics. Collaborate closely with leadership to t...
Reposted 2 weeks ago
Enterprise Principal Architect
$150K - $180K *
Elevate your career by guiding the architecture of cutting-edge enterprise systems, providing strategic technical direction and mentoring teams on best practices across .NET, Azure, and SQL Server to...
Reposted 1 week ago
Account Executive, Managed Services
$80K - $120K *
Engage clients by driving sales of Managed and Professional Services, identifying opportunities, and delivering tailored solutions. Cultivate relationships to exceed revenue targets while leveraging i...
5 days ago
$95K - $115K *
Drive customer engagement by showcasing innovative security solutions, addressing technical challenges, and collaborating with sales teams to enhance organizational safety and operational integrity in...
6 days ago
Transformation - Oracle Solution Architect
$169K - $226K *
Elevate your career by providing expert advisory and implementation services in Oracle solutions. Collaborate with clients to transform their business needs through full life cycle projects, ensuring...
2 weeks ago
Electronic Security Systems Engineer
$88K - $154K *
Engineer innovative Electronic Security Systems solutions for diverse clients, guiding projects from concept to construction. Collaborate with teams to ensure compliance with specifications and delive...
1 week ago
Oracle Principal Pre-Sales & Delivery Architect
$150K - $180K *
Unlock the potential of Oracle solutions by leading multi-engagement pre-sales and delivery efforts. Drive customer adoption and value through strategic solution design, ensuring seamless integration...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.