Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$150K - $180K *

Engage with key healthcare clients to drive strategic account management, fostering relationships and delivering tailored solutions across GE HealthCare’s diverse portfolio, while leading cross-functi...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$130K - $155K *

Lead the charge in creating cutting-edge embedded software solutions for autonomous mobile robotics. Drive technical excellence, oversee collaborative engineering efforts, and ensure high reliability...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$120K - $145K *

Join a dynamic team to architect and oversee cybersecurity and integration for a statewide Health Information Exchange, ensuring secure data management and compliance with healthcare standards while l...

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $145K *

Lead the technical architecture and cybersecurity strategy for a statewide Health Information Exchange, ensuring secure integration and compliance with healthcare privacy standards while managing vend...

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$125K - $150K *

Lead the charge in directing technical architecture and cybersecurity for a statewide Health Information Exchange, ensuring secure integration and compliance with healthcare privacy standards while ma...

Jackson, MSRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $145K *

Lead the technical architecture and cybersecurity strategy for a statewide Health Information Exchange, ensuring secure integration and compliance while guiding multidisciplinary teams and vendors to...

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $145K *

Unlock the potential of health data by leading the architecture and cybersecurity for a statewide Health Information Exchange, ensuring secure integration and compliance while guiding a multidisciplin...

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$85K - $120K *

Optimize the software development process by contributing to product-focused projects, addressing coding, debugging, automated testing, and performance enhancement to ensure scalable and efficient sof...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Real Estate & Construction

$85K - $120K *

Unlock innovation as a hands-on Software Engineer, driving Proofs-of-Concept and full software development cycles. Collaborate with senior engineers to explore emerging technologies while ensuring pro...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Drive profitable growth and market share by leading a high-performing sales team, building strategic customer relationships, and collaborating cross-functionally to enhance commercial performance and...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Transportation

$110K - $130K *

Optimize project delivery by leading enterprise SaaS implementations for utility clients. Build strong client relationships, manage competing priorities, and ensure successful project outcomes across...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$75K - $158K *

Bring your expertise to optimize and maintain the ServiceNow CMDB, ensuring data accuracy and reliability. Collaborate with IT teams to enhance service delivery across 187 bases, supporting a high-qua...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$109K - $129K *

Take ownership of product development in a dynamic, cross-functional team. Drive AI-assisted innovation from problem framing to launch, focusing on customer outcomes and strategic impact in a hyper-ag...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$180K - $240K *

Innovate by bridging software engineering and customer delivery, shaping core product capabilities while deploying AI solutions. Collaborate with teams to translate needs into robust systems, ensuring...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$349K - $437K *

Lead and innovate the global Cyber Defense organization, enhancing security posture through proactive threat identification, incident response, and strategic planning while collaborating with senior l...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Retail & Consumer Goods

$128K - $192K *

The Workday Financials Senior Principal Consultant, Record to Report is a dynamic professional responsible for leading the Financials workstream and ensuring operational efficiency in Workday engageme...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$108K - $115K *

Unlock your potential as a full stack engineer, collaborating in an agile team to develop innovative applications and features, while leveraging cutting-edge AI technologies to enhance product offerin...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$115K - $192K *

Engineer trusted, reusable data products by transforming architectural designs and business requirements into production-grade solutions. Collaborate with cross-functional teams to deliver innovative...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$192K - $338K *

Lead transformative AI and data strategies for enterprise accounts, driving value through hands-on engagement and technical leadership. Collaborate with executives to deliver tailored solutions that e...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Information Technology

$157K - $174K *

Drive impactful media strategies and foster PR excellence across U.S. and Israel. Collaborate with leadership to establish authority in AI security and exposure management while utilizing innovative A...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$84K - $187K *

Join the AI Automation team to innovate and implement AI solutions that enhance efficiency and security. Collaborate with experts to build automations, connect systems, and experiment with cutting-edg...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $207K *

Partner with us to drive enterprise AI adoption by assessing, deploying, and securing Microsoft 365 Copilot and Agent 365 capabilities. Leverage your expertise to enhance customer environments and ens...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$80K - $115K *

Engage with customers to ensure successful onboarding and implementation of solutions. Collaborate across teams to drive value, manage projects, and advocate for customer needs while building trusted...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Elevate your career by collaborating with cross-functional teams to enhance business operations, streamline processes, and drive value through effective analysis and documentation. Your expertise will...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Lead business development initiatives by building strategic partnerships and networks. Drive revenue growth through consultative selling and effective stakeholder management while fostering a collabor...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.