Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $115K *

Elevate project outcomes by managing complex initiatives, leading teams, and ensuring stakeholder alignment. Drive quality improvement and change management while fostering collaboration to achieve st...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$145K - $175K *

Shape the future of cybersecurity by leading Zero Trust architecture initiatives. Drive enterprise-wide strategies, develop reusable patterns, and ensure alignment with federal standards while guiding...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$87K - $157K *

Lead the charge in managing third-party program relationships, ensuring performance standards and financial accountability while facilitating effective communication between Delegation partners and in...

Missouri, USRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Elevate your career by designing and training advanced machine learning models. Collaborate with experts to analyze data, create reinforcement learning environments, and communicate findings effective...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$168K - $311K *

Advance strategic programs and market development to drive revenue growth and profitability for medical device products. Collaborate with cross-functional teams to enhance marketing and sales initiati...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $197K *

Elevate the future of medical science by engaging with healthcare professionals, driving strategic insights, and fostering scientific relationships to enhance clinical practices and medical knowledge...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$76K - $186K *

Join us in driving financial planning and forecasting to enhance Revenue, Billings, and Cash Flow. Collaborate with teams to create accurate models and provide insights that shape strategic decisions...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Join a team that's pioneering biomarker research in oncology clinical studies. Drive innovative strategies, collaborate with experts, and contribute to the development of transformative therapies that...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$143K - $165K *

Lead the design and delivery of enterprise technology solutions, driving innovation and growth. Oversee product lifecycles, mentor teams, and collaborate with stakeholders to ensure high-quality, scal...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$88K - $105K *

Transform your career by leading process engineering initiatives that enhance production efficiency and safety. Collaborate with teams to optimize workflows and drive continuous improvement in a dynam...

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Lead financial operations and reporting, ensuring compliance and efficiency. Drive strategic initiatives, manage a high-performing team, and collaborate with executives to enhance organizational perfo...

St. Louis, MORemote

2 days ago

  •   8 - 10 years exp.  •   Technical Services

$125K - $150K *

Join a dynamic team as you oversee accounting operations, ensuring accurate financial reporting and compliance. Lead a high-performing department while collaborating with executives to enhance company...

2 days ago

  •   8 - 10 years exp.  •   Technical Services

$95K - $171K *

Drive customer success by managing strategic partnerships in hospitality, ensuring seamless onboarding and tailored support. Foster relationships with stakeholders to optimize energy efficiency and en...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$136K - $212K *

Join a team that's driving strategic sales enablement initiatives to empower independent agents. Lead impactful projects, manage vendor partnerships, and collaborate across functions to enhance growth...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Lead business growth across NJ, PA, DE, MD & DC by developing new accounts, expanding existing relationships, and engaging key partners. Drive strategic initiatives and achieve sales goals in a dynami...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Optimize program management across the Customer Experience organization, ensuring strategic alignment and operational excellence. Lead cross-functional teams, establish governance frameworks, and driv...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$95K - $115K *

Optimize customer success by executing strategic account plans, driving product adoption, and fostering relationships to achieve risk adjustment and quality improvement goals. Collaborate with clients...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to enhancing healthcare applications through innovative development and support. Leverage your expertise in SYNON, COBOL, and RxCLAIM to drive impactful solutions in pharm...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$203K - $305K *

Transform regulatory intelligence by leading a global strategy that identifies and implements evolving regulatory requirements across diverse healthcare sectors, ensuring compliance and strategic alig...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$325K - $375K *

Lead strategic client engagement and relationship management for top-tier financial institutions. Drive revenue growth, mentor a high-performing team, and ensure delivery excellence while fostering lo...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$153K - $166K *

Empower the future of education by developing scalable web applications and cloud services. Collaborate with cross-functional teams to enhance digital assessment experiences, ensuring reliability and...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$70K - $100K *

Join a dynamic team to drive growth and enhance customer accounts through strategic sales techniques, data analysis, and effective communication, ensuring operational excellence and maximizing revenue...

2 days ago

  •   Less than 5 years exp.  •   Transportation

$85K - $95K *

Innovate cutting-edge solutions for public safety communications. Oversee presales projects, collaborating with sales teams to deliver tailored, high-impact solutions that meet the unique needs of fir...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$95K - $115K *

Transform data insights by developing robust Power BI solutions, ensuring data quality, and creating impactful visualizations. Collaborate with stakeholders to enhance reporting capabilities and deliv...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Develop and nurture partnerships with school districts to drive product adoption, enhance customer success, and ensure long-term retention through strategic implementation and proactive engagement...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.